Potential of Carica papaya leaf extract as an future medicine for thrombocytopenia in dengue patients: from traditional to scientific drug discovery

Yudisthira, Dewangga; Firdausi, Fortuna Filly; Alyani, Citra Fadia; Nurkolis, Fahrul; Al Rasyid, Harun; Yusuf, Vincentius Mario; Taslim, Nurpudji Astuti

doi:10.1007/s13596-023-00701-6

Cited by 1 publication

(1 citation statement)

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“…For example, Carica papaya leaf extract contains flavonoids and polyphenols and is an active pharmaceutical ingredient of Caripill™ tablets (10). It aids the increase in platelet count in dengue infection and other thrombocytopenic conditions (11,12). Vanillic acid (VA), a naturally occurring phenolic compound found in many edible plants and fruits possesses free radical scavenging, anticancer, antimutagenic, and antiangiogenic effects with multiple pharmacologic functions such as antimicrobial, anti-filarial, anti-inflammatory, and antioxidant activities.…”

Section: Introductionmentioning

confidence: 99%

Blood Plasma as a Sampling Model during Drug-induced Thrombocytopenia: Effects of Antioxidants

Ananthakrishna,

Mithun,

Harish

et al. 2024

BSCM

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OBJECTIVE Blood plasma, a complex biological mixture, plays a part in a variety of roles including clotting, defense, and transport, and reflects the overall status of blood components. Drug-induced thrombocytopenia (DIT) is characterized by abnormally low platelet count (below ~150,000 per μL) which can be caused by adverse effects of medications. This study aims to address a basic question, can plasma be employed as a sampling model to assess the oxidative stress (OS) changes and antioxidant status during DIT? The objective was to analyze the antioxidant status and OS in plasma during DIT, and to determine the effects of antioxidant supplementation such as Caripill™, L-Carnitine (LC), and vanillic acid (VA) during DIT. METHODS Male Wistar rats were used as animal models and grouped into control groups (n=5) and thrombocytopenia groups (n=5). Antioxidants were given to the thrombocytopenic and the control rats (50 mg/kg body weight) once a day for 7 days. Blood plasma from both groups was evaluated for total antioxidant capacity, antioxidant enzymes, markers of lipid peroxidation, protein oxidation, and OS. RESULTS The antioxidants significantly increased the total antioxidant capacity (CUPRAC) and ferric-reducing antioxidant power (FRAP) of the plasma and decreased the levels of conjugate dienes. Caripill™ also reduced lipid peroxidation, significantly elevated protein sulfhydryl and nitrite/nitrate levels, LC elevated lactate dehydrogenase levels, and VA increased superoxide dismutase activity and attenuated lipid peroxidation during DIT. CONCLUSIONS The antioxidants Caripill™, vanillic acid, and L-carnitine were demonstrated to be beneficial during DIT and to have prospects in alternate therapeutics. This study confirms that plasma can be utilized as a sampling model to study changes during OS situations.

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Section: Introductionmentioning

confidence: 99%