Potential of amorphous microporous silica for ibuprofen controlled release

Aerts, C.; Verraedt, Els; Depla, Anouschka; Follens, Lana; Froyen, Ludo; Humbeeck, Jan Van; Augustijns, Patrick; Mooter, Guy Van den; Mellaerts, Randy; Martens, Johan A.

doi:10.1016/j.ijpharm.2010.06.053

Cited by 37 publications

(27 citation statements)

References 39 publications

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“…SiO 2 materials from precursors such as tetraethylorthosilicate usually have a larger micropore volume and larger pores when prepared at higher HR, as observed for both unsupported materials [49][50][51] and membranes [52]. A higher HR also results in faster gelation of SiO 2 -based sols [16], and in larger fractal dimensions and gyration radii after a specific reaction time [49,50,53,54].…”

Section: Pore Structure Of Unsupported Hybrid Silicamentioning

confidence: 75%

Hybrid silica membranes with enhanced hydrogen and CO2 separation properties

Castricum

Qureshi

Nijmeijer

et al. 2015

Journal of Membrane Science

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Section: Pore Structure Of Unsupported Hybrid Silicamentioning

confidence: 75%

Hybrid silica membranes with enhanced hydrogen and CO2 separation properties

Castricum

Qureshi

Nijmeijer

et al. 2015

Journal of Membrane Science

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“…The silica gel materials obtained under the here described conditions are microporous with narrow monomodal pore size distribution and have been reported to be suitable for controlled release of drug molecules and antiseptic agents. [60][61][62][63][64] ' EXPERIMENTAL SECTION The sol-gel synthesis was performed at room temperature while continuously stirring with a magnetic bar. Typically, TEOS (Acros, 98%) was dissolved in ethanol (VWR, absolute grade, 99.9%).…”

Section: ' Introductionmentioning

confidence: 99%

²⁹Si NMR and UV−Raman Investigation of Initial Oligomerization Reaction Pathways in Acid-Catalyzed Silica Sol−Gel Chemistry

et al. 2011

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ABSTRACT:The initial molecular steps of the acid-catalyzed silica sol-gel process departing from tetraethylorthosilicate (TEOS) were investigated by in situ 29 Si NMR and UV-Raman spectroscopy. The use of a substoichiometric H 2 O:TEOS molar ratio (rvalue 0.2-1.2) slowed the silicate oligomerization reaction and allowed unraveling the initial steps of silica condensation. Molecular modeling confirmed Raman signal and 29 Si NMR shift assignment. A comprehensive listing of all Raman and 29 Si NMR assignments is provided, including unique Raman assignments of cyclosilicates and the linear tetramer. The combination of experiment and modeling allowed an analysis of the reaction kinetics. The derived kinetic model and the experimental observation both revealed that the H 2 O: TEOS molar ratio had a strong influence on the reaction kinetics but not on the reaction pathways. The multianalytical approach led to development of an oligomerization scheme. As dominant oligomerizations, chain growth, cyclodimerization, and branching were identified. Under the investigated conditions, chains did not grow longer than pentamer, and ring sizes were limited to 6-rings. Chains of 4 Si atoms and 4-rings were abundant species. Branched rings and chains were formed by attachment of dimers and trimers. Gelation proceeded from branched 4-rings and branched chains with limited hydroxyl functionalities.

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“…The controlled release of the molecules applied in the reservoir is governed by their diffusion through the mesoporous SiO 2 phase. It is well known that by controlling the pore morphology and/ or chemistry of SiO 2 materials the diffusion (and hence the release kinetics) of therapeutic molecules can be fine-tuned (Aerts et al, 2010;Bhaskara et al, 2014;Bhattacharyya et al, 2014;Santamaria et al, 2014;Verraedt et al, 2010). We hypothesise that incorporating a SiO 2 material with adequate pore characteristics will allow to adapt the system for any specific molecule.…”

Section: K De Cremer Et Almentioning

confidence: 92%

Controlled release of chlorhexidine from a mesoporous silica-containing macroporous titanium dental implant prevents microbial biofilm formation

Cremer

Braem²,

Gerits³

et al. 2017

eCM

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Roughened surfaces are increasingly being used for dental implant applications as the enlarged contact area improves bone cell anchorage, thereby facilitating osseointegration. However, the additional surface area also entails a higher risk for the development of biofilm associated infections, an etiologic factor for many dental ailments, including peri-implantitis. To overcome this problem, we designed a dental implant composed of a porous titaniumsilica (Ti/SiO 2 ) composite material and containing an internal reservoir that can be loaded with antimicrobial compounds. The composite material consists of a sol-gel derived mesoporous SiO 2 diffusion barrier integrated in a macroporous Ti load-bearing structure obtained by powder metallurgical processing. The antimicrobial compounds can diffuse through the porous implant walls, thereby reducing microbial biofilm formation on the implant surface. A continuous release of µM concentrations of chlorhexidine through the Ti/SiO 2 composite material was measured, without initial burst effect, over at least 10 days and using a 5 mM chlorhexidine solution in the implant reservoir. Metabolic staining, CFU counting and visualisation by scanning electron microscopy confirmed that Streptococcus mutans biofilm formation on the implant surface was almost completely prevented due to chlorhexidine release (preventive setup). Moreover, we demonstrated efficacy of released chlorhexidine against mature Streptococcus mutans biofilms (curative setup). In conclusion, we provide a proof of concept of the sustained release of chlorhexidine, one of the most widely used oral antiseptics, through the Ti/SiO 2 material thereby preventing and eradicating biofilm formation on the surface of the dental implant. In principle, our flexible design allows for the use of any bioactive compound, as discussed.

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Potential of amorphous microporous silica for ibuprofen controlled release

Cited by 37 publications

References 39 publications

Hybrid silica membranes with enhanced hydrogen and CO2 separation properties

Hybrid silica membranes with enhanced hydrogen and CO2 separation properties

²⁹Si NMR and UV−Raman Investigation of Initial Oligomerization Reaction Pathways in Acid-Catalyzed Silica Sol−Gel Chemistry

Controlled release of chlorhexidine from a mesoporous silica-containing macroporous titanium dental implant prevents microbial biofilm formation

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Potential of amorphous microporous silica for ibuprofen controlled release

Cited by 37 publications

References 39 publications

Hybrid silica membranes with enhanced hydrogen and CO2 separation properties

Hybrid silica membranes with enhanced hydrogen and CO2 separation properties

29Si NMR and UV−Raman Investigation of Initial Oligomerization Reaction Pathways in Acid-Catalyzed Silica Sol−Gel Chemistry

Controlled release of chlorhexidine from a mesoporous silica-containing macroporous titanium dental implant prevents microbial biofilm formation

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²⁹Si NMR and UV−Raman Investigation of Initial Oligomerization Reaction Pathways in Acid-Catalyzed Silica Sol−Gel Chemistry