Potential of acute phase proteins as predictor of postpartum uterine infections during transition period and its regulatory mechanism in dairy cattle

Manimaran, A.; Kumaresan, A.; Jeyakumar, Sakthivel; Mohanty, T.K.; Sejian, Veerasamy; Kumar, Naveen; Sreela, L.; Prakash, M. Arul; Mooventhan, P.; Anantharaj, Anbalagan; Das, Debanand

doi:10.14202/vetworld.2016.91-100

Cited by 31 publications

(31 citation statements)

References 82 publications

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“…Finally, the detection of biomarkers, such as liver proteins, regulatory hormones or acute phase proteins, has great potential for future health monitoring in ruminants, including in the context of helminth infection (Marco-Ramell et al 2016;Manimaran et al 2016). Advantages of such biomarker detection tools include that non-invasive sample matrices like saliva can be used and again that multiple parameters can be assessed and multiple pathogens can be detected in single samples.…”

Section: Global Advances In Diagnostic Toolsmentioning

confidence: 99%

Control of helminth ruminant infections by 2030

Charlier²,

et al. 2018

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Helminth infections have large negative impacts on production efficiency in ruminant farming systems worldwide, and their effective management is essential if livestock production is to increase to meet future human needs for dietary protein. The control of helminths relies heavily on routine use of chemotherapeutics, but this approach is unsustainable as resistance to anthelmintic drugs is widespread and increasing. At the same time, infection patterns are being altered by changes in climate, land-use and farming practices. Future farms will need to adopt more efficient, robust and sustainable control methods, integrating ongoing scientific advances. Here, we present a vision of helminth control in farmed ruminants by 2030, bringing to bear progress in: (1) diagnostic tools, (2) innovative control approaches based on vaccines and selective breeding, (3) anthelmintics, by sustainable use of existing products and potentially new compounds, and (4) rational integration of future control practices. In this review, we identify the technical advances that we believe will place new tools in the hands of animal health decision makers in 2030, to enhance their options for control and allow them to achieve a more integrated and sustainable approach to helminth control in support of animal welfare and production.

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Section: Global Advances In Diagnostic Toolsmentioning

confidence: 99%

Control of helminth ruminant infections by 2030

Charlier²,

et al. 2018

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“…Identification and recognition of biomarkers help in early diagnosis and assessment of the animal's pathophysiological condition of some diseases (Manimaran et al, 2016). Among these diseases is, asymptomatic endometritis known as subclinical endometritis (SCE) or cytological endometritis (Boby et al, 2017;Ghanem et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Subclinical endometritis and postpartum ovarian resumption in respect to TNF-±, IL-8 and CRP in Egyptian buffaloes

Elsayed¹,

El-Azzazi²,

Mahmoud³

et al. 2020

Anim Reprod

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The study was carried out to find the relation between subclinical endometritis (SCE) and postpartum (pp.) ovarian resumption as well as to evaluate serum and endometrial TNF-α, IL-8 and serum CRP in buffaloes with and without SCE. Thirty-nine pluriparous buffaloes at the 3 rd (W3), 5 th (W5) and 7 th (W7) week pp. were involved in this experiment. The parity of the buffaloes ranged from 4 to 8 with an average 5.8±0.2. Subclinical endometritis was diagnosed by the percentage of polymorphonuclear cells (PMNs) in uterine cytology obtained from endometrial cytobrush at W5 and W7. The cutoff point of PMNs% in buffaloes for SCE was ≥ 6% at W5 or ≥ 4% at W7. According to PMNs%, buffaloes were divided into SCE group (n=27) and non-SCE group (n=12). Ovarian cyclicity was monitored by rectal palpation, ultrasonography and progesterone assay at W3, W5 and W7. Serum and endometrial TNF-α, IL-8 and serum CRP were estimated at W5 and W7. Buffaloes with SCE (55.6%) showed delayed ovarian activity as compared to non-SCE (16.7%) animals (P=0.036). Significant increase in serum cytokines and CRP levels were detected at W5 (P ˂0.05) and W7 (P <0.01) in SCE buffaloes as compared to non-SCE. Endometrial levels of cytokines were significantly (P ˂0.05) elevated in SCE buffaloes. Serum and endometrial cytokines showed significant positive correlation. Furthermore, levels of TNF-α, IL-8 and CRP exhibited significant positive correlation with PMNs%. In conclusion, SCE delayed postpartum ovarian cyclicity in buffaloes. Moreover, TNF-α, IL-8 and CRP assessments could be efficient tools in prediction of SCE in buffaloes.

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“…Acute phase proteins are produced in the liver, synthesised by the agranulocytes, epithelial cells and found in different concentrations based on the state of animal health [24,25,26]. During any form of tissue injury, acute phase responses (APR) are initiated [27,28]. At this stage the APP either increases or reduces in concentration [29,30,31,32] reflecting the degree of damages in the tissue [24].…”

Section: Introductionmentioning

confidence: 99%

Acute Phase Proteins (Haptoglobin and Serum Amyloid A) and Pro-Inflammatory Cytokines (IL-12 and IL-10) in Cows Vaccinated with Prototype Killed S. aureus Mastitis Vaccine and Challenged with S. aureus Mastitis Infection.

Hambali

Abdallah

Bhuttu

et al. 2020

Preprint

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Background The economic downturn experienced by farmers and the fear of milk borne infection are of a greater public health concern. Haptoglobin, Serum Amyloid A, IL-12 and IL-10 in lactating Friesian cows vaccinated with prototype killed S. aureus mastitis vaccine and challenged with S. aureus were evaluated. Bacterin concentration at 10 8 cfu /ml of the local isolate of S. aureus was adjuvanted with KAl(SO₄)₂. Six lactating Friesian cows were grouped into A= Negative control, B = Positive control and C = vaccine group. Group C was vaccinated intramuscularly with 2ml of the monovalent vaccine, groups A and B with physiologic normal saline. Groups B and C were later challenged with the live bacterium via intramammary route . Result There was a significant increase in IL-10 concentration in vaccinated group post primary vaccination (PPV), booster phase (PB) and during the bacterial challenge phase. There was also a significantly increased IL-12 concentration in the vaccinated group at 24 hours, weeks 1 and 2 PPV. Haptoglobin at 12 and 24 hours PPV had a significant difference in group C. During the PB at 8 and 12 hours there was a significant difference in group C. During the bacterial challenged phase at 0, 3, 24 hours and day 7 PC there was a significant difference in group B. At 8 hours PC there was a significant difference in group C. For Serum Amyloid A, during PPV at 0, 3, 8, 12, 24 hours and weeks 1 and 2, the concentrations was significantly different in groups C. During PB at 0, 3, 8 and 12 hours PB there was a significant difference in groups C. During the bacterial challenge phase at 3, 8, 12, 24 hours, days 7 and 14 PC there was a significant difference in group B. At 0 hour PC there was a significant increase observed in group C. Conclusion The developed prototype killed S. aureus mastitis vaccine using local isolates was able to stimulate acute phase proteins and pro-inflammatory cytokines. The pattern of responses PC indicated protection, thereby suggesting that vaccination can protect against mastitis infection in dairy cows.

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Potential of acute phase proteins as predictor of postpartum uterine infections during transition period and its regulatory mechanism in dairy cattle

Cited by 31 publications

References 82 publications

Control of helminth ruminant infections by 2030

Control of helminth ruminant infections by 2030

Subclinical endometritis and postpartum ovarian resumption in respect to TNF-±, IL-8 and CRP in Egyptian buffaloes

Acute Phase Proteins (Haptoglobin and Serum Amyloid A) and Pro-Inflammatory Cytokines (IL-12 and IL-10) in Cows Vaccinated with Prototype Killed S. aureus Mastitis Vaccine and Challenged with S. aureus Mastitis Infection.

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