Potential nutritional healthy-aging strategy: enhanced protein metabolism by balancing branched-chain amino acids in a finishing pig model

Zhang, Lingyu; Guo, Qiuping; Duan, Yehui; Wang, Wenlong; Yang, Yaoqing; Yin, Yunju; Gong, Saiming; Han, Mengmeng; Li, Fengna; Yin, Yulong

doi:10.1039/d1fo03970a

Cited by 3 publications

(8 citation statements)

References 53 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[79] Thus, these findings suggest that the effects of leucine and its catabolites on signaling related to mitochondrial biogenesis in skeletal muscle might be dependent on fiber type. [79] Like leucine, mixtures of BCAA containing leucine have been consistently shown to increase mitochondrial biogenic signaling [33,55,57,[75][76][77]80] and/or function [55,80] in C57BL/6 mouse gastrocnemius, [57] C57BL/6 mouse heart, [57] male middle-aged mice-hybrid B6.129S2 soleus, [33] tibialis, [33] diaphragm, [33] and heart, [33] mice heart, [55] male rat liver, [80] and finishing pig adipose/muscle. [75][76][77] However, these effects may be dosage-, [57] diet-, [81] and/or exercise-dependent.…”

Section: Cox IV Protein Expressionmentioning

confidence: 99%

“…[79] Like leucine, mixtures of BCAA containing leucine have been consistently shown to increase mitochondrial biogenic signaling [33,55,57,[75][76][77]80] and/or function [55,80] in C57BL/6 mouse gastrocnemius, [57] C57BL/6 mouse heart, [57] male middle-aged mice-hybrid B6.129S2 soleus, [33] tibialis, [33] diaphragm, [33] and heart, [33] mice heart, [55] male rat liver, [80] and finishing pig adipose/muscle. [75][76][77] However, these effects may be dosage-, [57] diet-, [81] and/or exercise-dependent. [33,57] In mice, Abedpoor et al [57] showed BCAA supplementation increased expressional indicators of mitochondrial biogenesis in both skeletal and cardiac muscle of C57BL/6 mice.…”

Section: Cox IV Protein Expressionmentioning

confidence: 99%

“…Protein-restricted feed with 2.5% BCAA 2:2:1 (Leu:Ile:Val) 43 days ↑Ppargc1a, Opa1, Mtf2 mRNA expression Zhang 2022 [77] Finishing pigs (longissimus dorsi)…”

Section: Papmk Protein Expressionmentioning

confidence: 99%

“…Protein-restricted feed with 2.5% BCAA 2:1:2 (Leu:Ile:Val) 43 days ↑Opa1, Mtf2, ↔Ppargc1a mRNA expression Zhang 202 [77] Pigs (DSA) BCAA supplementation (adequate) with protein-restriction ↓Ppargc1a, Ucp2, Ucp3, Nrf1, Tfam, Prkaa, Atp6, ↔Cytc, Sirt1 mRNA expression; ↓pAMPK protein expression…”

Section: Papmk Protein Expressionmentioning

confidence: 99%

“…[ 76 ] Moreover, another similar study using longissimus dorsi muscle isolated from finishing pigs given a protein‐restricted diet (12% crude protein) supplemented with BCAA at various ratios showed increased Opa1 , Mfn2 , and Ppargc1a , which was also associated with increased mTORC1 activation. [ 77 ] Conversely, some evidence exists for reduced Ppargc1a expression in rats following the addition of dietary leucine at 3.2% to either a low (7%) or high‐fat (60%) diet for 42 days. [ 78 ] Specifically, gastrocnemius muscle displayed unchanged Ppargc1a expression following leucine supplementation in low‐fat‐fed rats, while leucine supplementation reduced Ppargc1a expression in high‐fat‐fed rats (but increased Pparg expression in both low‐ and high‐fat‐fed rats).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Branched‐Chain Amino Acids and Mitochondrial Biogenesis: An Overview and Mechanistic Summary

Hinkle

Rivera

Vaughan

2022

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Branched‐chain amino acids (BCAA) are essential in the diet and promote several vital cell responses which may have benefits for health and athletic performance, as well as disease prevention. While BCAA are well‐known for their ability to stimulate muscle protein synthesis, their effects on cell energetics are also becoming well‐documented, but these receive less attention. In this review, much of the current evidence demonstrating BCAA ability (as individual amino acids or as part of dietary mixtures) to alter regulators of cellular energetics with an emphasis on mitochondrial biogenesis and related signaling is highlighted. Several studies have shown, both in vitro and in vivo, that BCAA (either individual or as a mixture) may promote signaling associated with increased mitochondrial biogenesis including the upregulation of master regulator of mitochondrial biogenesis peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PGC‐1α), as well as numerous downstream targets and related function. However, sparse data in humans and the difficulty of controlling variables associated with feeding studies leave the physiological relevance of these findings unclear. Future well‐controlled diet studies will be needed to assess if BCAA consumption is associated with increased mitochondrial biogenesis and improved metabolic outcomes in healthy and/or diseased human populations.

show abstract

Section: Cox IV Protein Expressionmentioning

confidence: 99%

Section: Cox IV Protein Expressionmentioning

confidence: 99%

“…Protein-restricted feed with 2.5% BCAA 2:2:1 (Leu:Ile:Val) 43 days ↑Ppargc1a, Opa1, Mtf2 mRNA expression Zhang 2022 [77] Finishing pigs (longissimus dorsi)…”

Section: Papmk Protein Expressionmentioning

confidence: 99%

Section: Papmk Protein Expressionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Branched‐Chain Amino Acids and Mitochondrial Biogenesis: An Overview and Mechanistic Summary

Hinkle

Rivera

Vaughan

2022

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

Research progress of probiotics and fermented feed effects on pork quality

Lian,

Shi,

Lin

et al. 2024

Food Bioengineering

Self Cite

View full text Add to dashboard Cite

With the growth of the global population and the development of the economy, the demand for delicious and nutritious meat is increasing. However, the pursuit of high productivity and a high lean meat rate in pig breeding has led to a serious decline in meat quality. How to moderately improve the quality and flavor of pork through nutritional supplementation is of great significance in meeting consumers' demand for high‐quality and delicious pork. Recent studies have shown that fermented feed using probiotics can not only improve the nutritional quality and utilization rate of agricultural by‐products, but also play an important role in improving meat color, increasing intramuscular fat content, regulating the flavor of pork, leading to a sustainable development of agriculture and husbandry. In this paper, we will review the current situation of the probiotics used in fermented feed, the effects of fermentation on the improvement of feed quality, the influence and mechanism of fermented feed on the growth performance, meat quality, and flavor of pigs, and so forth, aiming to provide theoretical basis and technical support for the research and development of fermented feed and its application in the production of high‐quality pork.

show abstract

Study on Metabolic Effects of protein for Microbial Metabolic Engineering

Lin

2023

IJBLS

View full text Add to dashboard Cite

Microbial metabolic engineering is a new bioengineering technology, which can improve the yield of compounds, optimize energy utilization and solve various problems faced by human beings by changing the genetic information, metabolic pathway and metabolic flux of microorganisms. Protein is the main undertaker of life activities, and its metabolic process involves complex biochemical reactions and cell regulation mechanisms. Protein metabolism plays an important role and application in microbial metabolic engineering. The purpose of this paper is to explore the metabolic effects of protein for microbial metabolic engineering, so as to deeply understand the metabolic characteristics and regulation mechanism of microorganisms. Microbial metabolic engineering has important applications in improving the yield of compounds, optimizing energy utilization, environmental treatment and medicine. The research and application of protein metabolism can provide more in-depth theoretical basis and technical support for microbial metabolism engineering, thus promoting the development and utilization of microbial resources.

show abstract

Potential nutritional healthy-aging strategy: enhanced protein metabolism by balancing branched-chain amino acids in a finishing pig model

Abstract: Branched-chain amino acids (BCAAs) have key physiological roles in the regulation of protein synthesis, metabolism, food intake and aging. This study aimed to investigate the protective effect of balanced BCAAs...

Cited by 3 publications

References 53 publications

Branched‐Chain Amino Acids and Mitochondrial Biogenesis: An Overview and Mechanistic Summary

Branched‐Chain Amino Acids and Mitochondrial Biogenesis: An Overview and Mechanistic Summary

Research progress of probiotics and fermented feed effects on pork quality

Study on Metabolic Effects of protein for Microbial Metabolic Engineering

Contact Info

Product

Resources

About