Potential Nutraceutical Use of
            <i>Tribulus terrestris</i>
            L. in Human Health

Gunarathne, Rasika; Nadeeshani, Harshani; Lu, Anni; Li, Jinyao; Zhang, Baohong; Ying, Tianlei; Lu, Jun

doi:10.1080/87559129.2022.2067172

Cited by 7 publications

(6 citation statements)

References 121 publications

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“…Overall, TT , as a nutraceutical, has been used in traditional Chinese medicine, in Ayurvedic medicine in India, as well as by modern herbalists as an adjuvant for its various anti-inflammatory properties in inflammation-mediated diseases such as diabetes, obesity, pancreatitis, cancer, inflammatory bowel disease, kidney disease, and arthritis [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Tribulus terrestris L. on Sport and Health Biomarkers in Physically Active Adult Males: A Systematic Review

Fernández-Lázaro

Calvo

et al. 2022

IJERPH

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Tribulus terrestris L. (TT) is a plant used in traditional Chinese medicine, Ayurvedic medicine, and sports nutrition to improve health and performance. However, no conclusive evidence exists about the potential beneficial effects of TT on sport and health biomarkers in physically active adults. Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and the modified McMaster Critical Review Form for methodological quality assessment, we systematically reviewed studies indexed in Web of Science, Scopus, and PubMed, to assess the effects of TT on immunological, hematological, biochemical, renal, lipidic, hormonal behavior, and anti-inflammatory response in physically active adult males. Among 340 records identified in the search, a total of 7 studies met the inclusion and exclusion criteria. Overall, participants supplemented with TT displayed significant improvements in lipid profile. Inflammatory and hematological biomarkers showed moderate beneficial effects with no significant changes on renal biomarkers. No positive effects were observed on the immune system response. Additionally, no TT-induced toxicity was reported. In conclusion, there was no clear evidence of the beneficial effects of TT supplementation on muscle damage markers and hormonal behavior. More studies are needed to confirm the benefits of TT due to the limited number of studies available in the current literature.

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Section: Discussionmentioning

confidence: 99%

Effects of Tribulus terrestris L. on Sport and Health Biomarkers in Physically Active Adult Males: A Systematic Review

Fernández-Lázaro

Calvo

et al. 2022

IJERPH

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“…25 Various studies have reported the presence of phenolics, flavonoids, and anthraquinones in the A racemosus, M pruriens, A pyrethrum, and T terrestris used to prepare the PHP as a trweatment of liver injury in current study. [26][27][28][29][30][31] The presence of these phytochemicals with proven antioxidant potential are responsible for the reversal of liver injury in current study. 32 Kidneys play a vital role in the excretion of toxins such as creatinine, uric acid, and urea.…”

Section: Discussionmentioning

confidence: 99%

The Hepatoprotective and Anti-Nephrotoxic Potential of Methanolic Extract of a Polyherbal Preparation in CCl₄-Induced Liver Injury Model of Wistar Rats

et al. 2022

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The liver and kidneys are the vital organs of the body and perform important life-sustaining functions in the body. Synthetic drugs used in the treatment of liver and kidney diseases are sometimes inadequate and can lead to serious side effects. Medicinal herbs and plants were used to combat diseases for a long time and combination therapy is preferred over single plant therapy. In the current study, the Asparagus racemosus, Mucuna pruriens, Anacyclus pyrethrum, and Tribulus terrestris polyherbal preparation (PHP) was selected to evaluate its hepatoprotective, antioxidant, and anti-nephrotoxic potential. The methanolic extract of PHP was prepared following standard protocols. Fifty-six albino rats were divided into 7 groups (n = 8). The negative control (NC) having the healthy rats and the remaining 6 groups were induced liver toxicity by intraperitoneally injecting 0.5 mL/kg of 50% CCl4 in olive oil. Group 2 was positive control and group 3 and 4 received silymarin standard drug at the dose of 100 and 200 mg/kg body weight. Groups 5, 6, and 7 (PHP-1, PHP-2, PHP-3) were the liver-damaged rats receiving the PHP at a dose of 50, 100, and 150 mg/kg body weight. Blood samples were collected at 21 of the trial, to evaluate oxidative stress, hepatoprotective and anti-nephrotoxic potential. Results of liver function tests revealed significant ( P < .05) hepatoprotective activities of PHP after intoxication with CCl4 of albino rats as compared to standard groups. Moreover, results of renal functions also showed that PHP has a significant ( P < .05) restoring the capacity of blood urea, creatinine, and uric acid in intoxicated rats as compared with the control group. The PHP also reduced the oxidative stress in the treatment groups by increasing the total antioxidant capacity and reducing the total oxidative status. It can be concluded that selected medicinal plants have a potential role in the management of liver and kidney disorders. So, by running the clinical trial on a large scale and by isolating the phytochemical constituents responsible for hepatoprotective and nephroprotective activities, locally prepared drugs could be developed to manage liver and renal disorders.

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“…The results of numerous investigations revealed the presence of potential of T. terrestris compounds and various constituents that function as antioxidant, anti-inflammatory, anticancer, antidiabetic, androgens, cardiac, nephro-and hepato-protecting compounds (Gunarathne et al, 2022). It has been demonstrated that it causes hepatocellular carcinoma to proliferate less and induce cell death.…”

Section: Medicinal Propertiesmentioning

confidence: 99%

Phytotherapeutic Approaches for the Treatment of Animals in Pakistan: A One Health Perspective

Khan,

Ihsan

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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Phytotherapeutic means treating animals and humans with medicinal plants. In Pakistan, the tradition of treating humans and animals with beneficial natural plants has been practiced for centuries. Medicinal plants are advantageous for treatment due to their easy availability, minimal side effects, low cost, and ease of use for animals. The world is increasingly shifting towards natural products, given their minimal side effects, with a recent advancement being the one-health approach. This approach addresses issues related to human, animal, and environmental health. Various researchers in Pakistan have published different phytotherapeutic treatments, detailing the medicinal plants, their locations, and therapeutic effects. This chapter aims to identify the research conducted on herbal medicine in Pakistan and its application in veterinary practices. Additionally, it focuses on the current potential of phytotherapeutic approaches for animal care in Pakistan from a one health perspective. It is crucial to take serious action to encourage the sharing of traditional knowledge. The use of local herbal medicinal plants is not only economical but also greatly facilitates local farmers. However, more research is needed to systematically explore the methods for practically implementing such therapeutic approaches. Further investigation is necessary to develop effective strategies for the widespread application of these methods in practice.

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Potential Nutraceutical Use of Tribulus terrestris L. in Human Health

Cited by 7 publications

References 121 publications

Effects of Tribulus terrestris L. on Sport and Health Biomarkers in Physically Active Adult Males: A Systematic Review

Effects of Tribulus terrestris L. on Sport and Health Biomarkers in Physically Active Adult Males: A Systematic Review

The Hepatoprotective and Anti-Nephrotoxic Potential of Methanolic Extract of a Polyherbal Preparation in CCl₄-Induced Liver Injury Model of Wistar Rats

Phytotherapeutic Approaches for the Treatment of Animals in Pakistan: A One Health Perspective

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Potential Nutraceutical Use of Tribulus terrestris L. in Human Health

Cited by 7 publications

References 121 publications

Effects of Tribulus terrestris L. on Sport and Health Biomarkers in Physically Active Adult Males: A Systematic Review

Effects of Tribulus terrestris L. on Sport and Health Biomarkers in Physically Active Adult Males: A Systematic Review

The Hepatoprotective and Anti-Nephrotoxic Potential of Methanolic Extract of a Polyherbal Preparation in CCl4-Induced Liver Injury Model of Wistar Rats

Phytotherapeutic Approaches for the Treatment of Animals in Pakistan: A One Health Perspective

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Resources

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The Hepatoprotective and Anti-Nephrotoxic Potential of Methanolic Extract of a Polyherbal Preparation in CCl₄-Induced Liver Injury Model of Wistar Rats