Potential New Risk Factors for Ischemic Stroke

Abstract

Background and Purpose-About 60% to 80% of all ischemic strokes can be attributed to increasing blood pressure, blood cholesterol, cigarette smoking, carotid stenosis, and diabetes mellitus (atherosclerotic ischemic stroke), and atrial fibrillation and valvular heart disease (cardiogenic ischemic stroke). The aim of this review was to examine the potential role of other risk factors in the etiology of ischemic stroke. Summary of Review-About 10% to 20% of atherosclerotic ischemic strokes can probably be attributed to recently established, causal risk factors for ischemic heart disease: raised apoB/apoA 1 ratio, obesity, physical inactivity, pyschosocial stress and low fruit and vegetable intake. However, their causal role remains to be proven. The direct genetic contribution of any single gene towards ischemic stroke is likely to be modest and apply in selected patients only and in combination with environmental factors or via other epistatic (gene-gene or gene-environmental) effects. Conclusions-Research resources should not be allocated disproportionately to emerging novel risk factors that may account for up to only 20% of all strokes at the expense of researching the determinants of the relatively few established causal factors that account for up to 80% of all strokes.

Acil Servise Başvuran Akut İskemik İnmeli 124 Hastanın Geriye Yönelik Bir Yıllık İncelenmesi

“…Bu bulgular aynı zamanda Asya ve Orta Doğu ülkeleriyle benzerdir (27,28) . Kan basıncında artış, yüksek kolesterol düzeyi, karotis darlığı ve atriyal fibrilasyonun randomize klinik çalışmalarda iskemik inme ile nedensel ilişkisinin olduğu ve bunların tedavi edilmesi ile inme insidansında azalma olduğu kesin olarak gösterilmiştir (25,29) . Sigara, diabetes mellitus, iskemik kalp hastalığı ve valvüler kalp hastalığı iskemik inme için muhtemel risk faktörleridir.…”

Non-conventional risk factors were associated with infarct patterns in ischemic stroke

“…Further investigations are warranted to elucidate the effects of these agents as a potential stroke phenotype modifier. Although the role of novel risk factors currently available may be limited [38,39], our results raised the importance of continuous efforts to find the potentially modifiable risk factors associated with ischemic stroke [40].…”

Similarities and Differences in Epidemiology and Risk Factors of Cerebral and Myocardial Ischemic Disease

“…According to data collected from 23 corresponding studies, there is strong evidence that subjects with high physical activity as compared to those with low physical activity had a lower stroke risk [34].…”