Potential Neuroprotective Strategies for Traumatic Brain Injury

Farooqui, Akhlaq A.

doi:10.1007/978-1-4419-6652-0_7

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases 2010

DOI: 10.1007/978-1-4419-6652-0_7

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Potential Neuroprotective Strategies for Traumatic Brain Injury

Akhlaq A. Farooqui

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Cited by 2 publications

References 125 publications

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Statins and Neuroprotection: Basic Pharmacology Needed

2014

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Statins are attracting great interest albeit with some controversy in treating certain neurodegenerative diseases such as Alzheimer disease, Parkinson disease, multiple sclerosis, ischemic stroke, and traumatic brain injury. Support for the use of statins has come from human studies and animal and cell models. Despite the intense level of interest, there is a deficiency in information on the basic pharmacokinetics and pharmacodynamics of statins in the brain. The purpose of this focused review is to examine what is known and the gaps in our knowledge on detectability of statin lactones and acids in the brain, membrane partitioning and active transport of statins across the blood-brain barrier, and statin effects on brain isoprenoid levels. Statins may be efficacious in treating certain neurodegenerative diseases. Having basic information on statin pharmacokinetics and pharmacodynamics in the brain would provide insight into specific drug targets and also provide the rationale for optimizing statins in terms of enhancing brain influx and inhibiting efflux.

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Statins and Neuroprotection: Basic Pharmacology Needed

2014

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Omega-3 Fatty Acids as a Putative Treatment for Traumatic Brain Injury

Hasadsri

Wang

Lee

et al. 2013

Journal of Neurotrauma

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Traumatic brain injury (TBI) is a global public health epidemic. In the US alone, more than 3 million people sustain a TBI annually. It is one of the most disabling injuries as it may cause motor and sensory deficits and lead to severe cognitive, emotional, and psychosocial impairment, crippling vital areas of higher functioning. Fueled by the recognition of TBI as the "signature injury" in our wounded soldiers in Iraq and Afghanistan, and its often devastating impact on athletes playing contact sports, interest in TBI and TBI research has increased dramatically. Unfortunately, despite increased awareness of its detrimental consequences, there has been little progress in developing effective TBI interventions. Recent evidence, however, strongly indicates that nutritional intervention may provide a unique opportunity to enhance the neuronal repair process after TBI. To date, two omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have the most promising laboratory evidence for their neuro-restorative capacities in TBI. Although both animal models and human studies of brain injuries suggest they may provide benefits, there has been no clinical trial evaluating the effects of n-3 fatty acids on resilience to, or treatment, of TBI. This article reviews the known functions of n-3 fatty acids in the brain and their specific role in the cellular and biochemical pathways underlying neurotraumatic injury. We also highlight recent studies on the therapeutic impact of enhanced omega 3 intake in vivo, and how this may be a particularly promising approach to improving functional outcome in patients with TBI.

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Potential Neuroprotective Strategies for Traumatic Brain Injury

Cited by 2 publications

References 125 publications

Statins and Neuroprotection: Basic Pharmacology Needed

Statins and Neuroprotection: Basic Pharmacology Needed

Omega-3 Fatty Acids as a Putative Treatment for Traumatic Brain Injury

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