Potential multi-modal effects of provirus integration on HIV-1 persistence: lessons from other viruses

Linden, Noemi; Jones, R. Brad

doi:10.1016/j.it.2022.06.001

Cited by 5 publications

(3 citation statements)

References 109 publications

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“…ART cannot eradicate cells in which HIV-1 previral DNA is incorporated, which can act as a cell reservoir to store this DNA. As a result, these cell reservoirs may reseed the virus for reproduction when ART is discontinued ( Linden and Jones, 2022 ). Since memory T cells have a lengthy half-life, the proviral DNA of the virus that has been integrated into CD4 T cells may retain drug resistance-related mutations.…”

Section: Resultsmentioning

confidence: 99%

Development and emerging trends of drug resistance mutations in HIV: a bibliometric analysis based on CiteSpace

Chen,

Lai

2024

Front. Microbiol.

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BackgroundAntiretroviral therapy has led to AIDS being a chronic disease. Nevertheless, the presence of constantly emerging drug resistance mutations poses a challenge to clinical treatment. A systematic analysis to summarize the advancements and uncharted territory of drug resistance mutations is urgently needed and may provide new clues for solving this problem.MethodsWe gathered 3,694 publications on drug resistance mutations from the Web of Science Core Collection with CiteSpace software and performed an analysis to visualize the results and predict future new directions and emerging trends. Betweenness centrality, count, and burst value were taken as standards.ResultsThe number of papers on HIV medication resistance mutations during the last 10 years shows a wave-like trend. In terms of nation, organization, and author, the United States (1449), University of London (193), and Mark A. Wainberg (66) are the most significant contributors. The most frequently cited article is “Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update.” Hot topics in this field include “next-generation sequencing,” “tenofovir alafenamide,” “children,” “regimens,” “accumulation,” “dolutegravir,” “rilpivirine,” “sex,” “pretreatment drug resistance,” and “open label.” Research on drug resistance in teenagers, novel mutation detection techniques, and drug development is ongoing, and numerous publications have indicated the presence of mutations related to current medications. Therefore, testing must be performed regularly for patients who have used medications for a long period. Additionally, by choosing medications with a longer half-life, patients can take fewer doses of their prescription, increasing patient compliance.ConclusionThis study involved a bibliometric visualization analysis of the literature on drug resistance mutations, providing insight into the field’s evolution and emerging patterns and offering academics a resource to better understand HIV drug resistance mutations and contribute to the field’s advancement.

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Section: Resultsmentioning

confidence: 99%

Development and emerging trends of drug resistance mutations in HIV: a bibliometric analysis based on CiteSpace

Chen,

Lai

2024

Front. Microbiol.

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“…The quasispecies EIAV attenuated vaccine strains, that is, heterogeneous virus groups comprised closely related but not completely identical sequences (Wang et al 2018b, Liu et al 2019. Viral genetic characteristics in HIV-1 studies influence integration site selection, viral pathogenicity and disease progression (Anderson andMaldarelli 2018, Linden andJones 2022). The characteristics of various single virus integration sites within heterogeneous virus groups of vaccine strains require clarification.…”

Section: Future Research Perspectivesmentioning

confidence: 99%

“…The chromosomal environment of HIV-1 provirus integration sites demonstrably influences viral gene expression. It contributes to establishing latent or persistent infection, which likely also influences viral pathogenicity and disease progression (Anderson andMaldarelli 2018, Linden andJones 2022).…”

Section: Introductionmentioning

confidence: 99%

Review and future perspectives on the integration characteristics for equine lentivirus in the host genome

Liang

et al. 2023

Polish Journal of Veterinary Sciences

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Despite over 40 years of research on the human immunodeficiency virus type 1 (HIV-1) vaccine, we still lack a considerable progress. Equine infectious anemia virus (EIAV) is a lentivirus in the Retroviridae family, akin to HIV-1 in genome structure and antigenicity. EIA is an important infectious disease in equids, characterized by anemia, persistent infection, and repeated fevers. The EIAV attenuated vaccine in China is the only lentiviral vaccine used on a large scale. Elucidating the mechanism of waning and induction of protective immunity from this attenuated vaccine strain will provide a critical theoretical basis and reference point for vaccine research, particularly in the development of lentivirus vaccines, with far-reaching scientific value and social significance. In this paper, we summarize the information related to EIAV integration site selection, particularly for the Chinese EIAV attenuated vaccine strains on the equine genome. This may improve our mechanistic understanding of EIAV virulence reduction at the host genome level. The obtained data may help elucidate the biological characteristics of EIAV, particularly the Chinese attenuated EIAV vaccine strain, and provide valuable information regarding retroviral infections, particularly lentiviral infection and associated therapeutic vectors.

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HIV persistence: silence or resistance?

Pasternak

Berkhout

2023

Current Opinion in Virology

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Potential multi-modal effects of provirus integration on HIV-1 persistence: lessons from other viruses

Cited by 5 publications

References 109 publications

Development and emerging trends of drug resistance mutations in HIV: a bibliometric analysis based on CiteSpace

Development and emerging trends of drug resistance mutations in HIV: a bibliometric analysis based on CiteSpace

Review and future perspectives on the integration characteristics for equine lentivirus in the host genome

HIV persistence: silence or resistance?

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