Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation—A Randomized, Placebo-Controlled Trial

Abstract

Probiotic and omega-3 supplements have been shown to reduce inflammation, and dual supplementation may have synergistic health effects. We investigated if the novel combination of a multi-strain probiotic (containing B. lactis Bi-07, L. paracasei Lpc-37, L. acidophilus NCFM, and B. lactis Bl-04) alongside omega-3 supplements reduces low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) in elderly participants in a proof-of-concept, randomized, placebo-controlled, parallel study (NCT04126330). In this case, 76 community-dwelling elderly participants (median: 71.0 years; IQR: 68.0–73.8) underwent an intervention with the dual supplement (n = 37) or placebo (n = 39) for eight weeks. In addition to hs-CRP, cytokine levels and intestinal permeability were also assessed at baseline and after the eight-week intervention. No significant difference was seen for hs-CRP between the dual supplement group and placebo. However, interestingly, supplementation did result in significant increases in the level of the anti-inflammatory marker IL-10. In addition, dual supplementation increased levels of valeric acid, further suggesting the potential of the supplements in reducing inflammation and conferring health benefits. Together, the results suggest that probiotic and omega-3 dual supplementation exerts modest effects on inflammation and may have potential use as a non-pharmacological treatment for low-grade inflammation in the elderly.

The Role of Nrf2 and Inflammation on the Dissimilar Cardiotoxicity of Doxorubicin in Two-Time Points: a Cardio-Oncology In Vivo Study Through Time

“…Only the full knowledge of the patients will allow them to take the right steps to minimize the risk of cardiotoxicity. Several modulators of the inflammatory response such as non-steroidal anti-inflammatory drugs, glucocorticoids, natural products [ 85 ], omega-3 fatty acids, and probiotics [ 86 ] can modify the effects of DOX treatment and affect the prognosis.…”

Exploring the Impact of Personalized Nutritional Approaches on Metabolism and Immunity: A Systematic Review of Various Nutrients and Dietary Patterns

“…A total of 76 participants were enrolled, with 39 in the control group and 37 in the intervention group. The eight-week supplementation regimen showed no significant impact on the primary outcome measure, hs-CRP but revealed some minor differences in the anti-inflammatory marker interleukin (IL)-10 and stool levels of valeric acid [ 29 ]. Overall, the results suggest that the combination of probiotics and omega-3 supplements has moderate anti-inflammatory effects and could potentially be used as a non-pharmacological treatment for low-grade inflammation in the elderly.…”

“…Overall, the results suggest that the combination of probiotics and omega-3 supplements has moderate anti-inflammatory effects and could potentially be used as a non-pharmacological treatment for low-grade inflammation in the elderly. Further research is required to determine the potential benefits of these supplements in managing inflammation in older adults as suggested by the study authors [ 29 ].…”

Low-grade inflammation in the post-COVID period as a strategic goal of treatment and rehabilitation

“…В исследовании L. Tingö и соавт. оценивалось влияние совместного применения омега-3 и пробиотического препарата, содержащего B. lactis Bi-07, L. paracasei Lpc-37, L. acidophilus NCFM и B. lactis Bl-04, на уровень СРБ у 76 пожилых пациентов [57]. Уровень СРБ статистически значимо не отличался в экспериментальной группе и в группе контроля, однако примечательным является факт увеличения уровня циркулирующего ИЛ-10 в группе, получавшей комбинацию препаратов [57].…”