“…Therefore, it is essential to survey the pathogenesis mechanism of viral-caused disease through the alteration of the immune system function. One of the most effective approaches to surveying biological processes is systems biology, in which the whole system is studied rather than the individual parts ( 1 , 2 ). Computational systems biology and machine/deep learning methods rely on mathematical and statistical algorithms as well as the modeling of biological systems ( 3 , 4 ).…”