Potential medicinal application and toxicity evaluation of extracts from bamboo plants

Abstract

Bamboo plants play a significant role in traditional Asian medicine, especially in China and Japan. Biomedical investigations on the health-benefiting effects as well as toxicity of different parts and species of bamboo have been carried out worldwide since the 1960s, and a wide range of protective effects of bamboo-derived products has been documented, such as protection against oxidative stress, inflammation, lipotoxicity, cancer, and cardiovascular disease. Some of these products may interfere with male and female reproductive function, thyroid hormone metabolism, and hepatic xenobiotransformation enzymes. The diversity of bamboo species, parts of the plants available for medicinal use, and different extraction methods suggest that bamboo has great potential for producing a range of extracts with functional utility in medicine.

Cytotoxic, Apoptosis-Inducing Activities, and Molecular Docking of a New Sterol from Bamboo Shoot Skin Phyllostachys heterocycla var. pubescens

“…Supplementary Materials: The following are available online. Full characterization charts ( 1 HNMR, 13 CNMR, DEPT-135, COSY, HMBC, HSQ C, and mass spectroscopy) of the new compound, molecular docking files, and results are supported as a Supplementary File.…”

“…The structure of compound 1 (Figure 1) was proven to be a sterol-glucoside-fatty acid derivative, as deduced from the combined NMR and mass spectroscopic data. Extensive examination of 1 H NMR and 13 C NMR spectral data, together with the data of 1 H-1 H COSY, DEPT, HSQC, and HMBC experiments, allowed the establishment of a C-29 steroidal skeleton with a C-5/C-6 double-bond, as indicated from the two signals resonating at δ C 141.0 and 121.8, respectively. 1 H NMR revealed a multiplet resonating at δ H 3.88 attributed to H-3 with its corresponding carbon detected at δ C 78.8 in the 13 C NMR spectrum, confirming a glycoside link at this position.…”

“…HMBC correlation between the H 2 -6 resonating at δ H 4.76 and the signal detected at δ C 173.5 assigned to the carbonyl functionality (C-1") further supported the position of the fatty acid moiety. 13 C NMR values of the allylic methylene carbons C-7", C-10", and C-13" were determined at δ C 27.6, 25.9, and 27.5, respectively. This was based on the HMBC experiment, which correlated H-8", H-9", H-11", and H-12" (4 H, m, δ H 5.46) to C-7" (δ C 27.6), C-10" (δ C 25.9), and C-13" (δ C 27.5).…”

“…A chemical investigation of different bamboo species reported the isolation of phenolic compounds [8][9][10] and lignans [11], besides volatile compounds [12]. Previous studies demonstrated extracts from different parts of bamboo with different chemical compositions and promising antioxidative, anticancer, antibacterial, and antiallergic activities [13,14]. Some fractionated compounds from bamboo were previously screened for their anticancer activities with apoptosis induction, among which was a porphyrin photosensitizer that was extracted from bamboo leaves, and induced apoptotic cell death in human leukemia CMK-7 and colon adenocarcinoma Colo320 DM cell lines by caspase-3 activation and DNA cleavage [15].…”

Sasa Quelpaertensis Nakai Induced Antidepressant-Like Effect in Ovariectomized Rats

“…Recently, this bamboo grass gained more attention in traditional medicine due to its dietary phytochemicals (including p-coumaric acid and tricin) that boost general health [27][28][29][30][31][32]. It is reported that bamboo leaf extract enhanced the levels of acetylcholine and -aminobutyric acid (GABA) in rat's hippocampus and improved the learning and memory ability of dementia model rats [33].…”