Potential mechanisms of the heat-sink effect during microwave ablation of an in-vivo porcine liver model

Chiang, Jason; Martin, Jack A.; Nickel, K.P.; Kimple, Randall J.; Brace, Chris

doi:10.1016/j.jvir.2014.12.318

Cited by 3 publications

(1 citation statement)

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“…However, recent in vivo and in vitro studies have demonstrated that various vessel types may interact with heat differently (16). Hepatic veins are far more resistant to heat-induced vascular occlusion compared to portal veins and thus can act as a larger, more robust heat sink during thermal ablations (17). This result demonstrated the consequence of persistent heat sinks, with significantly smaller ablation zones in tissue that contain hepatic veins compared to portal veins.…”

Section: Discussionmentioning

confidence: 99%

4D Flow MR Imaging to Improve Microwave Ablation Prediction Models: A Feasibility Study in an In Vivo Porcine Liver

Chiang

Loecher

Moulin

et al. 2020

Journal of Vascular and Interventional Radiology

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Purpose-To characterize the effect of hepatic vessel flow using 4D flow MRI and correlate their effect on microwave ablation volumes in an in vivo non-cirrhotic porcine liver model.Materials and Methods-Microwave ablation antennas were placed under ultrasound guidance in each liver lobe of swine (n=3 in each animal) for a total of nine ablations. Pre-and post-ablation 4D flow MRI were acquired to quantify flow changes in the hepatic vasculature. Flow measurements, along with encompassed vessel size and vessel-antenna spacing were then correlated with ablation volume from segmented MR images. Results-The linear regression model demonstrated that the pre-ablation measurement of encompassed hepatic vein size (β = −0.80±0.25, 95% CI: [−1.15, −0.22]; p=0.02) was significantly correlated to final ablation zone volume. The addition of hepatic vein flow rate found via 4D flow MRI (β= −0.83 ± 0.65, 95% CI: [−2.50, 0.84]; p=0.26), and distance from antenna to hepatic vein (β= 0.26 ± 0.26, 95% CI: [ −0.40, 0.92]; p=0.36) improved the model accuracy but not significantly so (multivariate adjusted R 2 = 0.70 vs univariate (vessel size) adjusted R 2 = 0.63, p=0.24).Conclusions-Hepatic vein size in an encompassed ablation zone was found to be significantly correlated with final ablation zone volume. While the univariate 4D flow MRI-acquired measurements alone was not found to be statistically significant, its addition to hepatic vein size improved the accuracy of the ablation volume regression model. Pre-ablation 4D flow MRI of the liver may assist in prospectively optimizing thermal ablation treatment.

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Section: Discussionmentioning

confidence: 99%