Potential Mechanisms of Defective Brain Development in Schizophrenia

Jones, Edward G.; Akbarian, Schahram

doi:10.1007/978-1-4615-1955-3_3

Neural Development and Schizophrenia 1995

DOI: 10.1007/978-1-4615-1955-3_3

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Potential Mechanisms of Defective Brain Development in Schizophrenia

Edward G. Jones

Schahram Akbarian

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Cited by 2 publications

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“…Structural abnormalities seen in epileptic and schizophrenic brains are suggestive of alterations in cerebral cortical development [7,8]. Therefore, Neuroembryology also aims to include data which add to the understanding of the neurodevelopmental roots of schizophrenia and epilepsy.…”

mentioning

confidence: 99%

Neuroembryology – A Forum for Interactions between Basic Scientists and Clinicians

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2001

Neuroembryol Aging

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mentioning

confidence: 99%

Neuroembryology – A Forum for Interactions between Basic Scientists and Clinicians

Ulfig¹

2001

Neuroembryol Aging

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Hippocampal pyramidal cell disarray correlates negatively to cell number: implications for the pathogenesis of schizophrenia

Jönsson

Luts

Guldberg-Kjaer

et al. 1997

Eur Arch Psychiatry Clin Nuerosci

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Brains from patients with therapy-refractory schizophrenia were examined with respect to pyramidal cell disarray in the hippocampus, a finding reported in some studies, but not confirmed in others. A significantly higher number of disarrayed cells was seen in the brains of the schizophrenic patients in all subfields of the Cornu Ammonis (CA) investigated. Compared with controls the schizophrenic patients also had significantly fewer pyramidal cells in the observed areas of CA1-CA3, but not in CA4. There were no signs of gliosis. Finally, there was a significant negative correlation between the number of disarrayed cells and the total number of pyramidal cells in CA1-3 in the group of probands and controls taken together, a finding interpreted as lending support to the idea of a prenatal migratory disturbance in the pathogenesis of schizophrenic syndromes.

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Potential Mechanisms of Defective Brain Development in Schizophrenia

Cited by 2 publications

References 159 publications

Neuroembryology – A Forum for Interactions between Basic Scientists and Clinicians

Neuroembryology – A Forum for Interactions between Basic Scientists and Clinicians

Hippocampal pyramidal cell disarray correlates negatively to cell number: implications for the pathogenesis of schizophrenia

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