Potential mechanisms of action of the gut microbiota in antitumour immunity and immunotherapy
Qian Yin,
Jiao-Jiao Ni,
Jie-er Ying
Abstract:The gut microbiota significantly impacts antitumour immunity and alters
the effectiveness of cancer immunotherapy. Immunotherapies, notably
inhibitors of immune checkpoints that target programmed death 1 (PD-1)
and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), have
profoundly changed the way advanced and metastatic cancer is treated and
dramatically improved overall and progression-free survival. However,
the underlying molecular mechanisms by which the gut microbiota affects
antitumour immunity and th… Show more
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