Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins

Corbi, Graziamaria; Bianco, Andrea; Turchiarelli, Viviana; Cellurale, Michele; Fatica, Federica; Daniele, Aurora; Mazzarella, Gennaro; Ferrara, Nicola

doi:10.3390/ijms140612696

Cited by 61 publications

(41 citation statements)

References 130 publications

(129 reference statements)

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“…Its main effects are related to vasodilatation and bronchodilatation (Corbi et al, 2013b). In addition β 2 -AR is responsible for glycogenolysis (Corbi et al, 2002) and relaxation of uterine muscle.…”

Section: β-Adrenergic Signaling In the Heart At Molecular Levelmentioning

confidence: 99%

β-adrenergic receptor responsiveness in aging heart and clinical implications

et al. 2014

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Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called “β-adrenergic desensitization”). Adrenergic responsiveness is altered with aging and the age-related changes are limited to the β-adrenergic receptor density reduction and to the β-adrenoceptor-G-protein(s)-adenylyl cyclase system abnormalities, while the type and level of abnormalities change with species and tissues. Epidemiological studies have shown an high incidence and prevalence of heart failure in the elderly and a great body of evidence correlate the changes of β-adrenergic system with heart failure pathogenesis. In particular it is well known that: (a) levels of cathecolamines are directly correlated with mortality and functional status in heart failure, (b) β1-adrenergic receptor subtype is down-regulated in heart failure, (c) heart failure-dependent cardiac adrenergic responsiveness reduction is related to changes in G proteins activity. In this review we focus on the cardiovascular β-adrenergic changes involvement in the aging process and on similarities and differences between aging heart and heart failure.

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Section: β-Adrenergic Signaling In the Heart At Molecular Levelmentioning

confidence: 99%

β-adrenergic receptor responsiveness in aging heart and clinical implications

et al. 2014

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“…The sirtuins (Silent information regulator of transcription or SIRT), a family of enzymes, have recently been identified as the pivotal regulators of lifespan and health [4]. Mammals possess seven sirtuins, encoded by SIRT1-SIRT7.…”

Section: Introductionmentioning

confidence: 99%

SIRT1 gene is associated with cardiovascular disease in the Iranian population

Mohtavinejad

Nakhaee

Harati

et al. 2015

Egyptian Journal of Medical Human Genetics

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Background: Sirtuins (SIRT) have recently been identified as the pivotal regulators of lifespan and health. SIRT1 has protective effects against cardiovascular disease (CVD) and through its deacetylase activity it regulates numerous essential pathways including regulating blood pressure, reducing atherosclerosis, heart protection against oxidative stress and inducing cardiac cell survival and growth.Aims: Therefore, this study was conducted to evaluate whether two genetic polymorphisms of SIRT1 rs3758391 T/C and rs369274325 G/T are associated with the risk of CVD.Material and methods: A total of 500 Iranian subjects including 250 CVD patients and 250 healthy individuals as the control group were recruited in this case-control study. Genotyping of SIRT1 rs3758391 T/C and rs369274325 G/T polymorphisms were performed using PCR-RFLP and Tetra-ARMS PCR methods, respectively.Results: Our findings indicated a significant difference between two groups regarding the SIRT1 rs3758391 CC genotype in both additive and recessive models. The rs3758391 CC genotype was found to be more frequent in CVD patients than in the controls (19% vs. 6%), suggesting a statistically significant difference in either of additive (CC vs. TT; OR = 3.06, P = 0.001) as well as recessive models (CC vs. TT + CT genotype; OR = 3.72, P = 0.001).Conclusion: Our study for the first time suggests that the SIRT1 rs3758391 T/C polymorphism may confer an increased risk of CVD in both additive and recessive models, in this Iranian population.Ó 2014 Production and hosting by Elsevier B.V. on behalf of Ain Shams University.

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“…Oxidative stress is one of the mechanisms responsible of widespread endothelial dysfunction that in turn usually underlies the initial pathologic step of several pathological diseases, including CVD [4]. Indeed, endothelium should not be considered a mere lining between blood and tissues, but rather as an organ involved in crucial physiological functions including transportation of small and large molecules, vascular tone and blood flow regulation [5,6].…”

Section: Introductionmentioning

confidence: 99%