Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis

Wang, Lili; Li, Hongxia; Tang, Yuhan; Yao, Ping

doi:10.3389/fendo.2020.585285

Cited by 34 publications

(33 citation statements)

References 102 publications

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“…Frontiers in Pharmacology | www.frontiersin.org November 2021 | Volume 12 | Article 785220 (Wang et al, 2020). Angiotensin Ⅱ is a multifunctional hormone that plays a major role in the development of AS.…”

Section: Programmed Cell Death Of Macrophages and Interactions Of Efferocytosis Signalingmentioning

confidence: 99%

Roles of Macrophages in Atherogenesis

Farahi¹,

Sinha

Lusis

2021

Front. Pharmacol.

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Atherosclerosis is a chronic inflammatory disease that may ultimately lead to local proteolysis, plaque rupture, and thrombotic vascular disease, resulting in myocardial infarction, stroke, and sudden cardiac death. Circulating monocytes are recruited to the arterial wall in response to inflammatory insults and differentiate into macrophages which make a critical contribution to tissue damage, wound healing, and also regression of atherosclerotic lesions. Within plaques, macrophages take up aggregated lipoproteins which have entered the vessel wall to give rise to cholesterol-engorged foam cells. Also, the macrophage phenotype is influenced by various stimuli which affect their polarization, efferocytosis, proliferation, and apoptosis. The heterogeneity of macrophages in lesions has recently been addressed by single-cell sequencing techniques. This article reviews recent advances regarding the roles of macrophages in different stages of disease pathogenesis from initiation to advanced atherosclerosis. Macrophage-based therapies for atherosclerosis management are also described.

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Section: Programmed Cell Death Of Macrophages and Interactions Of Efferocytosis Signalingmentioning

confidence: 99%

Roles of Macrophages in Atherogenesis

Farahi¹,

Sinha

Lusis

2021

Front. Pharmacol.

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“…Their function in the pathogenesis of atherosclerosis is not clear, but it should be considered that they carry out the outflow of many xenobiotics and endogenous substances [37]. There are also data on the direct involvement of members of ABCC transporters in atherogenesis, such as ABCC1, which is found in vascular smooth muscle cells involved in the process of atherosclerosis [40].…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, the transport activity of ABCC may be involved in inflammation. Their importance in atherogenesis can also be emphasized by their participation in the transport of glutathione, oxidized glutathione, and leukotriene C4 (LTC4) [40][41][42], potentially necessary for the regulation of reactive oxygen species production in vascular cells. It is suggested that the release of LTC4 under the action of ABCC1 from vascular smooth muscle cells may be important in the early stages of atherosclerotic lesion development.…”

Section: Discussionmentioning

confidence: 99%

“…Later, macrophages are likely to be the main source of LTC4. Indeed, the modulation of ABCC1 expression in human aortic endothelial cells affects vascular function [40][41][42]. ABCC1 is also involved in the export of sphingosine-1-phosphate (S1P), a lipid mediator that is involved in inflammation, angiogenesis, apoptosis and macrophage function, and regulation of endothelial barrier integrity through modulation of the endothelial cytoskeleton [43][44][45][46][47][48][49][50][51][52].…”

Section: Discussionmentioning

confidence: 99%

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Analysis of ABC Transporter Gene Expression in Atherosclerosis

Kotlyarov

Kotlyarova

2021

Cardiogenetics

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ABC transporters are a large family of membrane proteins that transport chemically diverse substrates across the cell membrane. Disruption of transport mechanisms mediated by ABC transporters causes the development of various diseases, including atherosclerosis. Methods: A bioinformatic analysis of a dataset from Gene Expression Omnibus (GEO) was performed. A GEO dataset containing data on gene expression levels in samples of atherosclerotic lesions and control arteries without atherosclerotic lesions from carotid, femoral, and infrapopliteal arteries was used for analysis. To evaluate differentially expressed genes, a bioinformatic analysis was performed in comparison groups using the limma package in R (v. 4.0.2) and the GEO2R and Phantasus tools (v. 1.11.0). Results: The obtained data indicate the differential expression of many ABC transporters belonging to different subfamilies. The differential expressions of ABC transporter genes involved in lipid transport, mechanisms of multidrug resistance, and mechanisms of ion exchange are shown. Differences in the expression of transporters in tissue samples from different arteries are established. Conclusions: The expression of ABC transporter genes demonstrates differences in atherosclerotic samples and normal arteries, which may indicate the involvement of transporters in the pathogenesis of atherosclerosis.

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“…At the same time, the inflammatory macrophages secret and recruit a series of cytokines, such as interleukin 1 (IL-1) and chemoattractant protein 1(MCP-1), and this mechanism provides a theoretical basis for anti-inflammation therapy in atherosclerosis treatment ( Zhang et al, 2021a ). In addition, the clearance efficiency of apoptotic cells in atherosclerosis plaque is much lower owing to the impaired efferocytosis, which also contributes to atherosclerotic plaque formation ( Wang et al, 2020 ). In the primary stage of atherosclerosis, atherosclerotic plaques are lying underneath the blood vessel and keep in a stable state with the help of the extracellular matrix.…”

Section: The Pathology Of Atherosclerosis Involves Multiple Types Of Cellsmentioning

confidence: 99%

Epigenetic Regulation in Pathology of Atherosclerosis: A Novel Perspective

et al. 2021

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Atherosclerosis, characterized by atherosclerotic plaques, is a complex pathological process that involves different cell types and can be seen as a chronic inflammatory disease. In the advanced stage, the ruptured atherosclerotic plaque can induce deadly accidents including ischemic stroke and myocardial infarction. Epigenetics regulation, including DNA methylation, histone modification, and non-coding RNA modification. maintains cellular identity via affecting the cellular transcriptome. The epigenetic modification process, mediating by epigenetic enzymes, is dynamic under various stimuli, which can be reversely altered. Recently, numerous studies have evidenced the close relationship between atherosclerosis and epigenetic regulations in atherosclerosis, providing us with a novel perspective in researching mechanisms and finding novel therapeutic targets of this serious disease. Here, we critically review the recent discoveries between epigenetic regulation mechanisms in atherosclerosis.

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Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis

Cited by 34 publications

References 102 publications

Roles of Macrophages in Atherogenesis

Roles of Macrophages in Atherogenesis

Analysis of ABC Transporter Gene Expression in Atherosclerosis

Epigenetic Regulation in Pathology of Atherosclerosis: A Novel Perspective

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