Potential Mechanisms and Application of Honeybee Products in Wound Management: Wound Healing by Apitherapy

Oryan, Ahmad; Alemzadeh, Esmat

doi:10.1007/15695_2017_38

Cited by 3 publications

(7 citation statements)

References 122 publications

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“…Besides promoting wound healing, the broad-spectrum antimicrobial effect of honey was attributed to several factors including hydrogen peroxide production, acidity, nonperoxide molecules (e.g. methyl syringate, defensin 1 and methylglyoxal) and osmotic activity [6,[16][17][18][19]. When mixed with wound exudates, honey produces low level of hydrogen peroxide which is bactericidal causing irreversible damage to the bacterial membranes, proteins, enzymes and DNA [3,6].…”

Section: Discussionmentioning

confidence: 99%

“…methyl syringate, defensin 1 and methylglyoxal) and osmotic activity [6,[16][17][18][19]. When mixed with wound exudates, honey produces low level of hydrogen peroxide which is bactericidal causing irreversible damage to the bacterial membranes, proteins, enzymes and DNA [3,6]. Wounds show a biphasic response to hydrogen peroxide application.…”

Section: Discussionmentioning

confidence: 99%

“…Wounds show a biphasic response to hydrogen peroxide application. Low hydrogen peroxide concentrations enhance wound healing, but high levels delay healing [ 5 , 6 ]. Antioxidants in honey protect the wounds from oxygen radicals which may result from hydrogen peroxide actions [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Bacterial resistance to honey has not been reported because of the multiple antimicrobial mechanisms and components working additively and/or synergistically [ 6 , 18 , 21 , 22 , 24 , 25 ]. This multifactorial nature of honey could explain the wound healing progression in our study despite discontinuation of the initial course of antibiotics administered before complete epithelialisation without any secondary infections.…”

Section: Discussionmentioning

confidence: 99%

“…It stimulates collagen synthesis, angiogenesis and granulation tissue formation, promotes epithelialisation, and enhances wound contraction. It reduces pain, deodorises the wounds and has a debriding action lifting the debris from the wound [4][5][6]. Moreover, the high viscosity of honey provides a protective barrier preventing infection [7].…”

Section: Introductionmentioning

confidence: 99%

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Honey dressing: a missed way for orthopaedic wound care

Ahmed

Eltregy

Kandil

2022

International Orthopaedics (SICOT)

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Purpose Orthopaedic-related wounds are critical situations calling for care to avoid deep infections and its consequences. The purpose of this study was to evaluate the efficacy of using honey for care of orthopaedic-related wounds with limited resources. Patients and methods This prospective study included 50 cases with an average age of 38.18 (range 17–63) years with 38 males and 12 females. The most frequent wound location was the leg (41 patients; 82%), then the foot (six patients; 12%), and the ankle in three patients (6%). The aetiologies were open fractures (34 cases; 68%), infected tibial non-unions (nine cases; 18%), and post-operative infections (seven cases; 14%). Exposed tendon was present in three cases. Bone exposure was present in two cases. Deep infection was present in 29 cases (58%). Besides treating the primary cause, a ribbon of gauze soaked with honey was applied to the wounds after thorough saline washing. Results Wound sizes were variable. All cases showed improvement in all parameters with complete wound healing and full coverage of bone and tendons. Recurrence of deep infection occurred in three cases and treated by debridement. One case needed sequestrectomy of a small exposed tibial cortical fragment. Exposed tendon cases showed superficial necrosis which was treated by simple debridement. Initial mild itching occurred in five patients with spontaneous resolution. Conclusion With treating the underlying aetiology and optimising the patient’s general condition, honey was an effective, simple, and affordable method of wound care in different orthopaedic conditions even with exposed bone or tendons.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Honey dressing: a missed way for orthopaedic wound care

Ahmed

Eltregy

Kandil

2022

International Orthopaedics (SICOT)

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Physical Properties of Honey

Afroz¹,

Tanvir²,

Hossain³

2023

Honey

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A Comparative Study Between Use of Topical Honey and Edinburgh University’s Solution of Lime (EUSOL) Dressing in Necrotizing Fascitis Wounds

Rai¹,

Ghufran²,

Samo³

et al. 2023

Cureus

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IntroductionNecrotizing soft tissue infection is potentially life-threatening and involves subcutaneous fascial planes, later involving overlying skin and, eventually, underlying muscles. Early diagnosis and prompt treatment are necessary for this disease's management to avoid significant morbidity and fatality. After resuscitation and optimization, early surgical debridement is followed by serials of dressing. Various materials like Edinburgh University's solution of lime (EUSOL), normal saline, povidone-iodine, and honey have been used as dressing solutions for necrotizing fasciitis. This study is based on comparing the effects of honey and EUSOL as dressing solutions in necrotizing fasciitis wounds. MethodsA randomized clinical trial was conducted at the Civil Hospital Karachi, from March 2020 to July 2021. This study has been approved by the ethical review committee of the institution and registered at clinicaltrial.gov. Based on the dressing solution for necrotizing fasciitis, patients were divided into two groups, The honey group (intervention group) contains 90 patients, and the EUSOL group (control group) has 85 patients. ResultsA total of 175 patients' data were analyzed, 90 in the honey group and 85 in the EUSOL group. Patients presented to the hospital with symptoms of 6.20 ± 2.72 days in the honey group and 6.67 ± 4.08 days in the EUSOL group. The days required for clearance of slough in the honey group were 2.83 ± 0.79, while 2.48 ± 0.82 days in the EUSOL group with a p-value of 0.005. The duration of hospital stay was 4.96 ± 1.31 days in the intervention group and 9.33 ± 1.45 days in the control group, with a p-value of 0.007. Wound healing days were 20.23 ± 4.45 in the intervention group while 28.38 ± 7.06 days in the control group, with a significant p-value of 0.000. ConclusionWhile managing necrotizing soft tissue infection wounds with honey. Honey promotes faster wound healing and shorter hospital stays compared to EUSOL.

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Potential Mechanisms and Application of Honeybee Products in Wound Management: Wound Healing by Apitherapy

Cited by 3 publications

References 122 publications

Honey dressing: a missed way for orthopaedic wound care

Honey dressing: a missed way for orthopaedic wound care

Physical Properties of Honey

A Comparative Study Between Use of Topical Honey and Edinburgh University’s Solution of Lime (EUSOL) Dressing in Necrotizing Fascitis Wounds

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