2002
DOI: 10.1183/09031936.02.00203602
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Potential masking effect on dyspnoea perception by short- and long-acting β2-agonists in asthma

Abstract: Asthma patients evaluate the effect of medication treatment through the degree of their asthma symptoms, which might be affected by their ability to perceive these symptoms. It has been suggested that b 2 -agonists may mask the effects of an increase in airway inflammation. This study compared the perception of histamineinduced bronchoconstriction during monotherapy with short-or long-acting b 2 -agonists.Asthmatic patients (68 male and 60 female, mean age 35¡11 yrs, forced expiratory volume in one second (FEV… Show more

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Cited by 17 publications
(12 citation statements)
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“…There was no relation at baseline between subjective symptoms and lung function, probably due to temporal adaptation to pre-existing obstruction 32,33 : at the end of the histamine provocation there was a correlation between changes in subjective symptoms and lung function. In contrast to previous findings, 3,4,34 we found no relation between the participants' perceptual sensitivity for dyspnea and physiological measures of disease severity such as FEV 1 and histamine dose level at 20% decrease of FEV 1 .…”
Section: Discussioncontrasting
confidence: 99%
“…There was no relation at baseline between subjective symptoms and lung function, probably due to temporal adaptation to pre-existing obstruction 32,33 : at the end of the histamine provocation there was a correlation between changes in subjective symptoms and lung function. In contrast to previous findings, 3,4,34 we found no relation between the participants' perceptual sensitivity for dyspnea and physiological measures of disease severity such as FEV 1 and histamine dose level at 20% decrease of FEV 1 .…”
Section: Discussioncontrasting
confidence: 99%
“…This difference supports prior reports suggesting that African Americans may have differential perception of their asthma symptoms and perhaps their asthma severity, compared with whites, similar to other ethnicities (18). Because LABA use has been reported to attenuate asthma symptom perception (24), it is possible that in this population of individuals who already report fewer symptoms and use less asthma rescue medication, this class of therapy may be potentially detrimental and Table 4 and survival analysis is used for the figures. The subset of subjects used for each treatment in each analysis is the same.…”
Section: Discussionmentioning
confidence: 99%
“…Excessive use of short-acting β 2 -agonists (SABAs) in the absence of ICS use has long been linked to hospitalisations and asthma deaths, best exemplified by asthma death epidemics related to high doses of fenoterol reported in New Zealand and other countries [136]. Also, regular use of long-acting β 2 -agonists (LABAs) in the absence of ICS has been shown to increase significantly the risk of asthma exacerbations and asthma deaths potentially through a "masking" effect [137][138][139]. Not only overuse, but also regular use, of SABA (without ICS [140]) has also been associated with paradoxical asthma worsening [52,141].…”
Section: Environmental Factors: Indoor/outdoor Air Pollution and Occumentioning
confidence: 99%