Potential involvement of JNK1 repression in the hepatic effect of sitagliptin and metformin in rats subjected to high fat diet and chronic mild distress

Magdy, Yosra; El-Kharashi, Omnyah A.; Nabih, Enas Samir; Shaker, Safaa M.; Abd-Elaziz, Lobna F.; Aboul‐Fotouh, Sawsan

doi:10.1016/j.biopha.2016.10.098

Cited by 15 publications

(10 citation statements)

References 63 publications

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“…In spite of the failure of sitagliptin to reverse the depression-like phenotype, the contribution of DPP-4 in depression-like behaviour cannot be totally ruled out, since sitagliptin successfully counteracts the depression-like behaviour induced by HFD in rats. 25 In addition, sitagliptin exerts antidepressant effects in experimental paradigms of depression-like behaviour such as the forced swim test and tail suspension test in mice. 61 The absence of such an antidepressant effect in our study reinforces the contention that HFD induces depression-like behaviour through distinct pathophysiological mechanisms.…”

Section: Hfd-induced Changes In Molecules Relevant To Brain Functionmentioning

confidence: 99%

High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome

Hassan

Mancano

Kashofer

et al. 2018

Nutritional Neuroscience

133

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Section: Hfd-induced Changes In Molecules Relevant To Brain Functionmentioning

confidence: 99%

High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome

Hassan

Mancano

Kashofer

et al. 2018

Nutritional Neuroscience

133

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“…In fact, several studies have used a HFD and/or adding a certain amount of cholesterol or sugar to intervene in rodents and observed the effects of high cholesterol on anxiety/depression-like behaviour. A fat-rich diet (>20%) and adding 0.2% to 2.5% cholesterol can induce anxiety/depressive behaviour in male mice and rats [73][74][75][76][77]. A low-fat diet with 0.2% to 10% cholesterol [78][79][80] can also induce anxiety/depressive behaviour in female mice but no anxiety/depressive behaviour in male rats [77].…”

Section: Dietary Fat Contentmentioning

confidence: 99%

“…Depressive and anxiety-like behaviours as well as cognitive impairment were positively correlated with the highest weight, plasma leptin levels, and LepRb protein and mRNA levels in the hippocampus and hypothalamus [55]. Several studies [74,76] used a diet containing 2% cholesterol to feed rats for 8-12 weeks and exposed them to chronic restraint stress (CRS) for 6-8…”

Section: Chronic Unpredictable Mild Stress-induced Depression Modelmentioning

confidence: 99%

“…Depressive-and anxiety-like behaviours as well as cognitive impairment were positively correlated with the highest weight, plasma leptin levels and LepRb protein and mRNA levels in the hippocampus and hypothalamus (55) . Several studies (74,76) used a diet containing 2 % cholesterol to feed rats for 8-12 weeks and exposed them to chronic restraint stress for 6-8 weeks. In addition to abnormal liver lipids, atherosclerosis and other metabolic disorders, with the high cholesterol intervention, the rats later developed depression-like behaviours, cognitive impairment and diminished object recognition memory as well.…”

Section: Chronic Unpredictable Mild Stress-induced Depression Modelmentioning

confidence: 99%

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Dietary and metabolic risk of neuropsychiatric disorders: insights from animal models

et al. 2021

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Neuropsychiatric disorders are major causes of the global burden of diseases, frequently co-occurring with multiple comorbidities, especially obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease and its various risk factors in metabolic syndrome. While the determining factors of neuropsychiatric disorders are complex, recent studies have shown that there is a strong link between diet, metabolic state and neuropsychiatric disorders, including anxiety and depression. There is no doubt that rodent models are of great value for preclinical research. Therefore, this article focuses on a rodent model of chronic consumption of high-fat diet (HFD), and/or the addition of a certain amount of cholesterol or sugar. Meanwhile, summarizes the pattern of diet that induces anxiety/depressive-like behaviour and the underlying mechanism. We highlight how dietary and metabolic risk influence neuropsychiatric behaviour in animals. Changes in dietary patterns, especially HFD, can induce anxiety or depression-like behaviours, which may vary by diet exposure period, sex, age, species, and genetic background of the animals used. Furthermore, dietary patterns significantly aggravate anxiety/depression-like behaviour in animal models of neuropsychiatric disorders. The mechanisms by which diet induces anxiety/depressive-like behaviour may involve neuroinflammation, neurotransmitters/neuromodulators, neurotrophins, and the gut-brain axis. Future research should be focused on elucidating the mechanism and identifying the contribution of diet and diet-induced metabolic risk to neuropsychiatric disorders, which can form the basis for future clinical dietary intervention strategies for neuropsychiatric disorders.

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“…Likewise, DPP-4-deficient congenic rats showed enhanced stress resilience (Canneva et al, 2015 ). The DPP-4 inhibitor sitagliptin has an antidepressant effect as it reduces the immobility time in the forced swim test and tail suspension test in mice, and prevents the high fat diet-induced prolongation of immobility time in the forced swim test in rats (Kamble et al, 2016 ; Magdy et al, 2017 ). In humans, incretin-based therapies, which include DPP-4 inhibitors and GLP-1 analogs, reduce depression symptoms in patients who have type 2 diabetes.…”

Section: Dpp-4-like Activity Of the Gut Microbiota: Potential Impact mentioning

confidence: 99%

The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health

et al. 2018

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The Dipeptidyl peptidase-4 (DPP-4) activity influences metabolic, behavioral and intestinal disorders through the cleavage of key hormones and peptides. Some studies describe the existence of human DPP-4 homologs in commensal bacteria, for instance in Prevotella or Lactobacillus. However, the role of the gut microbiota as a source of DPP-4-like activity has never been investigated. Through the comparison of the DPP-4 activity in the cecal content of germ-free mice (GFM) and gnotobiotic mice colonized with the gut microbiota of a healthy subject, we bring the proof of concept that a significant DPP-4-like activity occurs in the microbiota. By analyzing the existing literature, we propose that DPP-4-like activity encoded by the intestinal microbiome could constitute a novel mechanism to modulate protein digestion as well as host metabolism and behavior.

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Potential involvement of JNK1 repression in the hepatic effect of sitagliptin and metformin in rats subjected to high fat diet and chronic mild distress

Cited by 15 publications

References 63 publications

High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome

High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome

Dietary and metabolic risk of neuropsychiatric disorders: insights from animal models

The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health

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