Potential Intra- or Cross-Network Functional Reorganization of the Triple Unifying Networks in Patients with Frontal Glioma

Liu, Dongming; Hu, Xinhua; Liu, Yong; Yang, Kun; Xiao, Chaoyong; Hu, Jun; Li, Zonghong; Zou, Yuanjie; Chen, Jiu; Liu, Hongyi

doi:10.1016/j.wneu.2019.04.248

Cited by 18 publications

(20 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies reported that gliomas may significantly impair cognitive functions (Derks et al, ; Liu et al, ; Noll et al, ; Pace et al, ; van Kessel, Baumfalk, van Zandvoort, Robe, & Snijders, ). Notably, significant differences were found in math exam test, DSST, mapping test, and similarity test between HCs and in patients with glioma before surgery, which was partially consistent with previous studies.…”

Section: Discussionmentioning

confidence: 98%

“…To our knowledge, focal deficits caused by glioma are not restricted to the area where the tumor is located and where it has caused local damage; however, it may impact the global dysfunctioning of the brain (Almairac, Duffau, & Herbet, ; Hart, Romero‐Garcia, Price, & Suckling, ; Maesawa et al, ). Some studies have suggested that localized tumors can affect the function of distant part of the brain (Liu et al, ; Park, Kim, Kim, Kim, & Shim, ; Zhang et al, ). Indeed, structural changes in the regions distant from brain tumor have also been confirmed by some studies (Almairac et al, ; Bouwen et al, ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Restructuring of contralateral gray matter volume associated with cognition in patients with unilateral temporal lobe glioma before and after surgery

Yang

et al. 2019

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

Glioma can cause variable alterations to the structure and function of the brain. However, there is a paucity of studies on the gray matter (GM) volume alterations in the brain region opposite the temporal glioma before and after surgery. Therefore, the present study was initiated to investigate the alternation in contralateral homotopic GM volume in patients with unilateral temporal lobe glioma and further, assess the relationship between GM volume alternations with cognition. Eight left temporal lobe glioma patients (LTPs), nine right temporal lobe glioma patients (RTPs), and 28 demographically matched healthy controls (HCs) were included. Using voxel‐based morphometry method, alternations in the contralateral homotopic GM volume in patients with unilateral temporal lobe glioma was determined. Furthermore, the correlation analysis was performed to explore the relationship between cognitive function and altered GM volume. In the preoperative analysis, compared to HCs, LTPs exhibited increased GM volume in right inferior temporal gyrus and right temporal pole (superior temporal gyrus), and, RTPs presented increased GM volume in left inferior temporal gyrus. In the postoperative analysis, compared to HCs, RTPs presented increased GM volume in left middle temporal gyrus. Furthermore, the increased GM volume was significantly positively correlated with the memory test but negatively correlated with the visuospatial test. This study preliminarily confirmed that there were compensatory changes in the GM volume in the contralateral temporal lobe in unilateral temporal lobe glioma patients. Furthermore, alterations of GM volume may be a mechanism for cognitive function compensation.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Restructuring of contralateral gray matter volume associated with cognition in patients with unilateral temporal lobe glioma before and after surgery

Yang

et al. 2019

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

show abstract

“…The default-mode network (DMN), composed of bilateral and symmetrical hubs distributed across the ventromedial prefrontal, posteromedial, and inferior parietal, as well as the lateral and medial temporal cortex, is a critical circuit that deactivates during goal-directed tasks and which is involved in the monitoring of internally generated processes, e.g., autobiographical memory recollection, self-monitoring, and internal and external cognition [ 41 , 77 , 78 ]. Several series using preoperative rsfMRI in tumor patients noted a reduced FC across DMN areas in comparison with HC [ 76 , 79 , 80 ].…”

Section: The Contribution Of Fni and Tms Mapping To Investigate Inmentioning

confidence: 99%

Functional Mapping before and after Low-Grade Glioma Surgery: A New Way to Decipher Various Spatiotemporal Patterns of Individual Neuroplastic Potential in Brain Tumor Patients

Duffau

2020

Cancers

View full text Add to dashboard Cite

Intraoperative direct electrostimulation mapping (DEM) is currently the gold-standard for glioma surgery, since functional-based resection allows an optimization of the onco-functional balance (increased resection with preserved quality of life). Besides intrasurgical awake mapping of conation, cognition, and behavior, preoperative mapping by means of functional neuroimaging (FNI) and transcranial magnetic stimulation (TMS) has increasingly been utilized for surgical selection and planning. However, because these techniques suffer from several limitations, particularly for direct functional mapping of subcortical white matter pathways, DEM remains crucial to map neural connectivity. On the other hand, non-invasive FNI and TMS can be repeated before and after surgical resection(s), enabling longitudinal investigation of brain reorganization, especially in slow-growing tumors like low-grade gliomas. Indeed, these neoplasms generate neuroplastic phenomena in patients with usually no or only slight neurological deficits at diagnosis, despite gliomas involving the so-called “eloquent” structures. Here, data gained from perioperative FNI/TMS mapping methods are reviewed, in order to decipher mechanisms underpinning functional cerebral reshaping induced by the tumor and its possible relapse, (re)operation(s), and postoperative rehabilitation. Heterogeneous spatiotemporal patterns of rearrangement across patients and in a single patient over time have been evidenced, with structural changes as well as modifications of intra-hemispheric (in the ipsi-lesional and/or contra-lesional hemisphere) and inter-hemispheric functional connectivity. Such various fingerprints of neural reconfiguration were correlated to different levels of cognitive compensation. Serial multimodal studies exploring neuroplasticity might lead to new management strategies based upon multistage therapeutic approaches adapted to the individual profile of functional reallocation.

show abstract

“…1,16,38 Functional compensation can be classified into specific function and functional networks. 13,16,20 Functional compensation frequently manifests as altered blood flow or metabolism at the resting state or ABBREVIATIONS ALFF = amplitude of low-frequency fluctuation; DSST = Digital Symbol Substitution Test; FC = functional connectivity; fMRI = functional MRI; GRF = gaussian random field; HGG = high-grade glioma; LGG = low-grade glioma; MNI = Montreal Neurological Institute; ROI = region of interest; TFCE-FWE = threshold-free cluster enhancement family-wise error.…”

mentioning

confidence: 99%

“…4,24,43 Reorganization of the resting-state networks has been observed in various pathological conditions involving brain damage, such as stroke and brain tumors. 5,20,36 It is, however, not completely clear whether the functional reorganization in patients with hemispheric focal glioma is supported by modifications in the contralesional homotopic region, or if that plays any role in global network integration.…”

mentioning

confidence: 99%

Contralesional homotopic functional plasticity in patients with temporal glioma

Liu

Chen

et al. 2021

Journal of Neurosurgery

Self Cite

View full text Add to dashboard Cite

OBJECTIVEThis study aimed to explore the contralesional homotopic functional plasticity in the brain of patients with unilateral temporal glioma.METHODSDemographic, neurocognitive, and resting-state functional MRI data were collected from 17 patients with temporal glioma (10 in the right lobe and 7 in the left lobe), along with 14 age- and sex-matched healthy controls. The amplitude of low-frequency fluctuation (ALFF) of the contralesional homotopic region and 2 control regions was examined. The region-of-interest–based analysis was used to determine the altered functional connectivity (FC) of the contralesional homotopic region, showing significantly different intrinsic regional brain activity between patients and controls. Partial correlation analysis was conducted to determine the association between the altered neural activity and behavioral characteristics.RESULTSCompared with controls, patients with right temporal glioma exhibited significantly increased ALFF in the contralesional homotopic hippocampus and parahippocampal region. In addition, the intrinsic regional activity in these regions was negatively correlated with the visuospatial score (r = −0.718, p = 0.045). Whole-brain FC analysis revealed significantly increased FC between the left hippocampus and parahippocampal regions and the left inferior temporal gyrus, and decreased FC between the left hippocampus and parahippocampal regions and the left inferior frontal gyrus. No significant changes were found in the 2 control regions.CONCLUSIONSContralesional homotopic regions are instrumental in the process of neural plasticity and functional compensation observed in patients with unilateral temporal glioma. The observed findings might be used to help preoperative evaluation or rehabilitation of postsurgical patients.

show abstract

Potential Intra- or Cross-Network Functional Reorganization of the Triple Unifying Networks in Patients with Frontal Glioma

Cited by 18 publications

References 47 publications

Restructuring of contralateral gray matter volume associated with cognition in patients with unilateral temporal lobe glioma before and after surgery

Restructuring of contralateral gray matter volume associated with cognition in patients with unilateral temporal lobe glioma before and after surgery

Functional Mapping before and after Low-Grade Glioma Surgery: A New Way to Decipher Various Spatiotemporal Patterns of Individual Neuroplastic Potential in Brain Tumor Patients

Contralesional homotopic functional plasticity in patients with temporal glioma

Contact Info

Product

Resources

About