Potential Interaction Between Warfarin and High Dietary Protein Intake

Hornsby, Lori B.; Hester, E. Kelly; Donaldson, Amy R.

doi:10.1592/phco.28.4.536

Cited by 28 publications

(10 citation statements)

References 10 publications

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“…Concerns over the interaction between WF and foods have been reported in case reports and reviews (Holbrook et al ., ; Nutescu et al ., ; Paeng et al ., ; Leung et al ., ; Hornsby et al ., ). In these reports, some symptoms induced by ineffectiveness of WF or unexpected prolongation of clotting time including excessive bleeding have been encountered mostly in patients who suffered venous thrombosis, cardiac infarction, or cerebral embolism.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of Food–drug Interaction of Guava Leaf Tea

Kaneko

Suzuki

Iwadate-Iwata

et al. 2012

Phytotherapy Research

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Guava leaf tea (GLT) contains guava leaf polyphenol (Gvpp), which regulates the absorption of dietary carbohydrate from the intestines. Borderline diabetics, who are at high risk of development of diabetes, take GLT to suppress a rapid increase of blood sugar level after meals. However, patients with diabetes in whom diabetic drugs or warfarin as a blood thinner are prescribed also take GLT with the expectation of glycemic control. Therefore, we studied whether GLT had potential for inhibition or induction of cytochrome P450 (CYP) and an influence on the action of warfarin. Extract of guava leaf (GvEx) consists of carbohydrate and polyphenols, which are Gvpp, quercetin, and ellagic acid. These polyphenols, but not GvEx, showed a certain level of inhibition of human-cDNA-expressed CYPs. In a comparison of GLT and grapefruit juice, GLT showed weaker inhibition of CYP activities and of midazolam 1'-hydroxylation than grapefruit juice. Furthermore, neither liver weight nor CYP3A expression in the liver was changed in rats that received GvEx for 90 days compared with the control group. When rats were concomitantly treated with GLT and warfarin, the prolongation of clotting time of blood by warfarin was not influenced. These data suggest that GLT is unlikely to interact with drugs.

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Section: Discussionmentioning

confidence: 97%

Evaluation of Food–drug Interaction of Guava Leaf Tea

Kaneko

Suzuki

Iwadate-Iwata

et al. 2012

Phytotherapy Research

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“…21 Patients taking warfarin are at particular risk of interactions with dietary supplements, yet approximately 30% use herbal or natural product supplements on a regular basis. 22 There is a possible interaction between warfarin and a highprotein diet.…”

Section: Warfarinmentioning

confidence: 99%

Food Drug Interactions

Bushra¹,

Aslam²,

Khan³

2011

OMJ

199

147

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The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction), food, beverages, dietary supplements the person is consuming (drug-nutrient/food interaction) or another disease the person has (drug-disease interaction). A drug interaction is a situation in which a substance affects the activity of a drug, i.e. the effects are increased or decreased, or they produce a new effect that neither produces on its own. These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances. Regarding food-drug interactions physicians and pharmacists recognize that some foods and drugs, when taken simultaneously, can alter the body's ability to utilize a particular food or drug, or cause serious side effects. Clinically significant drug interactions, which pose potential harm to the patient, may result from changes in pharmaceutical, pharmacokinetic, or pharmacodynamic properties. Some may be taken advantage of, to the benefit of patients, but more commonly drug interactions result in adverse drug events. Therefore it is advisable for patients to follow the physician and doctors instructions to obtain maximum benefits with least food-drug interactions. The literature survey was conducted by extracting data from different review and original articles on general or specific drug interactions with food. This review gives information about various interactions between different foods and drugs and will help physicians and pharmacists prescribe drugs cautiously with only suitable food supplement to get maximum benefit for the patient.

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“…Accordingly, considering the high content of bioactive compounds and phytochemicals in plant foods [160], a personalized nutrition (Figure 1) should take into account potential food-drug interactions in veterans who are in treatment for comorbidities. In agreement, dietetic interventions based on personalized dietary advice have also been suggested for old subjects [161], in order to avoid potential food-drug interactions [162][163][164][165][166][167][168][169][170]. In particular, the effect of high-protein, low-carbohydrate diets on warfarin efficacy should be taken into consideration [169,170].…”

Section: Healthy Diet For Veteransmentioning

confidence: 99%

Nutraceutical-based Integrative Medicine: Adopting a Mediterranean Diet Pyramid for Attaining Healthy Ageing in Veterans with Disabilities

Ciccotti¹,

Raguzzini

Sciarra³

et al. 2019

CPD

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Veterans with disability represent a big burden worldwide and often require long-term rehabilitation. Unhealthy dietary and lifestyle habits, including smoke and alcohol abuse, are common in veterans. In the context of integrative medicine approaches, the "complementary and alternative medicine" has been suggested for the management of chronic diseases. However, the potential risk of interaction between herbal products, dietary supplements and drugs must be considered in veterans. The Mediterranean diet has been suggested as a natural, non-pharmacological nutraceutical for healthy ageing. Although there is a broad consensus on the positive effect of plant foods consumption, the presence of glucosinolates, flavonoids and furanocoumarins in some plant foods and beverages must be taken into consideration owing to their potential interfering with drugs metabolism and bioavailability. Albeit seasonality could ensure the maintenance of the single dose of phytochemical below that at which adverse effects in some individuals genetically predisposed or unpleasant drug interactions in diseased subjects can occur, a personalized nutrition is recommended in veterans who are under treatment for comorbidities. Furthermore, sports practice can lead veterans with motor disabilities and mental impairments to excel in some disciplines, giving rise to the phenomenon of the Paralympics and the development of "recreational therapy". Moreover, outdoor lifestyle, through vitamin D synthesis, and conviviality, improving socialization, could account for the Mediterranean lifestyle health benefits. In this work, we propose for veterans a Mediterranean Pyramid, which could be the basis for integrative medicine for veterans with disabilities, patient-centered approaches and interprofessional (including physical medicine and rehabilitation clinicians, pharmacists and nutritionists) interventions.

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Potential Interaction Between Warfarin and High Dietary Protein Intake

Cited by 28 publications

References 10 publications

Evaluation of Food–drug Interaction of Guava Leaf Tea

Evaluation of Food–drug Interaction of Guava Leaf Tea

Food Drug Interactions

Nutraceutical-based Integrative Medicine: Adopting a Mediterranean Diet Pyramid for Attaining Healthy Ageing in Veterans with Disabilities

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