Potential insulin secretagogue effects of isovitexin and swertisin isolated from Wilbrandia ebracteata roots in non-diabetic rats

Abstract

The antihyperglycemic effect and mechanism of action of extracts, fractions and compounds from Wilbrandia ebracteata was studied. The crude extract reduced the glycemia, increased glycogen content and serum insulin in hyperglycemic rats. Also, a significant effect was observed with the n-butanol and metanol subfraction. However, the antihyperglycemic effect of the n-butanol fraction was not observed in diabetic rats. The C-glycosylflavones isovitexin and swertisin showed a strong antihyperglycemic action compared with the extracts and fractions. These results show that the extracts, fractions, and isolated C-glycosylflavones have an antihyperglycemic action that was reinforced by the stimulation on in vivo insulin secretion.

Reduction of Adipogenesis and Lipid Accumulation by Taraxacum officinale (Dandelion) Extracts in 3T3L1 Adipocytes: An in vitro Study

“…These phytochemicals show anti-oxidant and anti-inflammatory activities and have been described to be beneficial in obesity and related pathologies (Lin et al, 2005;Meotti et al, 2006;Moon and Kim, 2012;Sato et al, 2011;Xagorari et al, 2001). Notable examples include the hypolipidemic and hypoglycemic effects in rats exerted by luteolin 7-Oglucoside (Azevedo et al, 2010) and hesperidin (Akiyama et al, 2009) and hypoglycemic effects of isovitexin (Folador et al, 2010). Finally, in vitro studies with chlorogenic and caffeic acids have been shown to inhibit adipogenesis in 3T3-L1 cells (Hsu et al, 2006;Juman et al, 2010).…”

Aleurites moluccana(L.) Willd. Leaves: Mechanical Antinociceptive Properties of a Standardized Dried Extract and Its Chemical Markers

“…Previous studies conducted with the flavonoid swertisin revealed its potential as an agent that stimulates insulin secretion presenting antihyperglycemic effect [32], but no analgesic studies with this flavonoid have yet been conducted; except for tge work in [33] done on the flavonoid-enriched fraction from Cayaponia tayuya roots which included swertisin. …”

Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition

“…In addition to the a-glucosidase inhibiton, vitexin (1) exhibited significant antinociceptive effect in an analgesic chemical model (Gorzalczany et al, 2011). Isovitexin (2) was reported to significantly stimulate insulin secretion in hyperglycemic rats (Folador et al, 2010) and exhibited antioxidant greater than a-tocopherol (Masuoka et al, 2003).…”