Potential innovation against Alzheimer’s disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery

Karthika, Chenmala; Appu, Anoop Pattanoor; Akter, Rokeya; Rahman, Md. Habibur; Tagde, Priti; Ashraf, Ghulam Md; Abdel-Daim, Mohamed M.; Hassan, Syed Shams ul; Abid, Areha; Bungău, Simona

doi:10.1007/s11356-021-17830-7

Cited by 32 publications

(21 citation statements)

References 128 publications

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“…Intranasal administration of liposomes containing quercetin, an antioxidant, was also found to be a viable method of delivery [ 167 ]. The usage of quercetin liposomes has been found to reduce neuronal oxidative stress, which is a key factor in the neuropathogenesis of Alzheimer’s disease [ 168 ].…”

Section: Advances In Drug Delivery Across the Blood–brain Barriermentioning

confidence: 99%

Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

et al. 2022

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The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB. The BBB is disturbed in specific pathological illnesses such as stroke, diabetes, seizures, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The goal of this study is to offer a general overview of current brain medication delivery techniques and associated topics from the last five years. It is anticipated that this review will stimulate readers to look into new ways to deliver medications to the brain. Following an introduction of the construction and function of the BBB in both healthy and pathological conditions, this review revisits certain contested questions, such as whether nanoparticles may cross the BBB on their own and if medications are selectively delivered to the brain by deliberately targeted nanoparticles. Current non-nanoparticle options are also discussed, including drug delivery via the permeable BBB under pathological circumstances and the use of non-invasive approaches to improve brain medication absorption.

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Section: Advances In Drug Delivery Across the Blood–brain Barriermentioning

confidence: 99%

Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

et al. 2022

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“…Clinically recognized targets of Alzheimer′s disease (AD) include beta-secretase (BACE-1) and cholinesterase, both of which have benefited greatly from natural products [ 54 ]. Considering AD is a significant public health concern, it needs the use of multi-targeted medications to treat it [ 55 , 56 ].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Reviewing the Traditional/Modern Uses, Phytochemistry, Essential Oils/Extracts and Pharmacology of Embelia ribes Burm.

et al. 2022

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Objectives: Embelia ribes Burm. (E. ribes, Myrsinaceae), also known as Vidanga in Ayurveda, has been shown to have significant therapeutic benefits on several disorders, and its main chemical bioactive constituent, embelin, has the therapeutic potential to be converted into innovative drugs, which is why it has recently received considerable interest. In the present work, we provide a higher level of comprehension, awareness, and extensive knowledge of the traditional uses, phytochemistry, and pharmacological characteristics of E. ribes throughout the last several decades (February 1965 to June 2021), emphasizing the importance of the study of essential oils extracted from E. ribes, which show a major potential for exerting antioxidant and anti-inflammatory activity. Materials and Methods: Google Scholar, MEDLINE, EMBASE, Scifinder, Scopus, and ScienceDirect were used to conduct a thorough literature search. Results: E. ribes is high in essential oils, alkaloids, flavonoids, steroids, and phenolics, all of which have medicinal benefits. The essential oils/extracts and isolated chemical constituents exhibited antioxidant activity, wound healing, antidiabetic, central nervous system (CNS)-related disease, antiviral, antiobesity, cardioprotective, antifungal, antibacterial, and antifertility activity, among other promising pharmacological effects. Conclusion: The translation between traditional applications and modern medicine may make E. ribes a promising target for the implementation of innovative medication. To investigate the efficacy and safety profile of E. ribes, further high-quality preclinical studies using advanced methodologies are required.

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“…Medicinal herbs and herbal therapies are gaining popularity as complementary and alternative interventions to create medication candidates for AD. Several scientific investigations have documented the use of numerous medicinal plants and their main phytochemicals in the treatment of AD [50,51]. The increasing collection of epidemiological and experimental research shows that eating fruits and vegetables protects the brain from the negative consequences of oxidative stress, neuroinflammation, and aging.…”

Section: Inhibition Of Acetylcholinesterase Activity Using Natural Co...mentioning

confidence: 99%

Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease

Wang¹,

Kong²,

Chen

et al. 2022

Molecules

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Alzheimer’s disease (AD) is a progressive neurological condition. The rising prevalence of AD necessitates the rapid development of efficient therapy options. Despite substantial study, only a few medications are capable of delaying the disease. Several substances with pharmacological activity, derived from plants, have been shown to have positive benefits for the treatment of AD by targeting various enzymes, such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), β-secretase, γ-secretase, and monoamine oxidases (MAOs), which are discussed as potential targets. Medicinal plants have already contributed a number of lead molecules to medicine development, with many of them currently undergoing clinical trials. A variety of medicinal plants have been shown to diminish the degenerative symptoms associated with AD, either in their raw form or as isolated compounds. The aim of this review was to provide a brief summary of AD and its current therapies, followed by a discussion of the natural compounds examined as therapeutic agents and the processes underlying the positive effects, particularly the management of AD.

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Potential innovation against Alzheimer’s disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery

Cited by 32 publications

References 128 publications

Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

Reviewing the Traditional/Modern Uses, Phytochemistry, Essential Oils/Extracts and Pharmacology of Embelia ribes Burm.

Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease

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