Potential inhibition of HIV-1 encapsidation by oligoribonucleotide&amp;ndash;dendrimer nanoparticle complexes

Parboosing, Raveen; Chonco, Louis; Mata, F. Javier de la; Govender, Thavendran; Maguire, Glenn E. M.; Kruger, Hendrik G.

doi:10.2147/ijn.s114446

Cited by 14 publications

(13 citation statements)

References 59 publications

(72 reference statements)

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“…In addition, high biocompatibility and significant reduction in p24 antigen production was observed in cell culture and intracellularly. 133 In a study by Parboosing et al, 134 RNA decoys in the form of a 16-mer oligoribonucleotide originating from the stem loop 3 of the HIV packaging signal, were attached to dendrimers in an effort to disrupt the packaging process of the HIV life cycle. The results of this study demonstrated efficient delivery into lymphocytes and modest cytoprotective effect against HIV infection.…”

Section: Antiviral Nanotherapeuticsmentioning

confidence: 99%

“…The results of this study demonstrated efficient delivery into lymphocytes and modest cytoprotective effect against HIV infection. 134 Jayant et al, 135 demonstrated that an ARV (tenofovir) and an investigational latency-reversing drug 136 (vorinostat) can be co-encapsulated on ultrasmall (10 ± 3 nm) iron oxide nanoparticles. This research achieved a sustained drug release period (increased by 30%) showing absolute drug release profiles over a 5-day period with simultaneous activation of latent HIV in cultured human astrocytes.…”

Section: Antiviral Nanotherapeuticsmentioning

confidence: 99%

“…The results of this study demonstrated efficient delivery into lymphocytes and modest cytoprotective effect against HIV infection. 134…”

Section: Antiviral Nanotherapeuticsmentioning

confidence: 99%

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The role of nanotechnology in the treatment of viral infections

Singh

Kruger

Maguire

et al. 2017

Therapeutic Advances in Infection

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246

248

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Infectious diseases are the leading cause of mortality worldwide, with viruses in particular making global impact on healthcare and socioeconomic development. In addition, the rapid development of drug resistance to currently available therapies and adverse side effects due to prolonged use is a serious public health concern. The development of novel treatment strategies is therefore required. The interaction of nanostructures with microorganisms is fast-revolutionizing the biomedical field by offering advantages in both diagnostic and therapeutic applications. Nanoparticles offer unique physical properties that have associated benefits for drug delivery. These are predominantly due to the particle size (which affects bioavailability and circulation time), large surface area to volume ratio (enhanced solubility compared to larger particles), tunable surface charge of the particle with the possibility of encapsulation, and large drug payloads that can be accommodated. These properties, which are unlike bulk materials of the same compositions, make nanoparticulate drug delivery systems ideal candidates to explore in order to achieve and/or improve therapeutic effects. This review presents a broad overview of the application of nanosized materials for the treatment of common viral infections.

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Section: Antiviral Nanotherapeuticsmentioning

confidence: 99%

Section: Antiviral Nanotherapeuticsmentioning

confidence: 99%

See 1 more Smart Citation

The role of nanotechnology in the treatment of viral infections

Singh

Kruger

Maguire

et al. 2017

Therapeutic Advances in Infection

Self Cite

246

248

View full text Add to dashboard Cite

show abstract

“…[111][112][113] The antiviral efficiency of nanosystems was a result of viral entry inhibition, activation of CD8 + T cell and/ or antibody mediated response and in some case RNA decoys. 111,113,114 Investigations regarding the efficacy of dendrimers as a nanoperticulated system for designing an antiviral therapy have been introduced by some of the pioneering researches, but their efficiency against NiV is yet to be evaluated.…”

Section: Dendrimersmentioning

confidence: 99%

Nano-based approach to combat emerging viral (NIPAH virus) infection

Kerry

Malik

Redda

et al. 2019

Nanomedicine: Nanotechnology, Biology and Medicine

104

107

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Emergence of new virus and their heterogeneity are growing at an alarming rate. Sudden outburst of Nipah virus (NiV) has raised serious question about their instant management using conventional medication and diagnostic measures. A coherent strategy with versatility and comprehensive perspective to confront the rising distress could perhaps be effectuated by implementation of nanotechnology. But in concurrent to resourceful and precise execution of nano-based medication, there is an ultimate need of concrete understanding of the NIV pathogenesis. Moreover, to amplify the effectiveness of nano-based approach in a conquest against NiV, a list of developed nanosystem with antiviral activity is also a prerequisite. Therefore the present review provides a meticulous cognizance of cellular and molecular pathogenesis of NiV. Conventional as well several nano-based diagnosis experimentations against viruses have been discussed. Lastly, potential efficacy of different forms of nano-based systems as convenient means to shield mankind against NiV has also been introduced.

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“…The mechanism of encapsidation, where HIV RNA is packaged into nascent virions, is driven by interactions between by the Gag nucleocapsid protein p7 and a region of the HIV genome known as the packaging signal (Ψ). A decoy RNA, mimicking the Ψ signal, complexed with a third-generation CBS dendrimer was shown to be efficiently delivered to lymphocytes and exerting a cytoprotective effect against HIV, nevertheless, with only a minor suppression of HIV viral load [ 164 , 165 ].…”

Section: Applications Of Dendrimersmentioning

confidence: 99%

Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials

et al. 2017

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In recent years innovative nanostructures are attracting increasing interest and, among them, dendrimers have shown several fields of application. Dendrimers can be designed and modified in plentiful ways giving rise to hundreds of different molecules with specific characteristics and functionalities. Biomedicine is probably the field where these molecules find extraordinary applicability, and this is probably due to their multi-valency and to the fact that several other chemicals can be coupled to them to obtain desired compounds. In this review we will describe the different production strategies and the tools and technologies for the study of their characteristics. Finally, we provide a panoramic overview of their applications to meet biomedical needs, especially their use as novel antimicrobials.

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Potential inhibition of HIV-1 encapsidation by oligoribonucleotide–dendrimer nanoparticle complexes

Cited by 14 publications

References 59 publications

The role of nanotechnology in the treatment of viral infections

The role of nanotechnology in the treatment of viral infections

Nano-based approach to combat emerging viral (NIPAH virus) infection

Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials

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