Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic

Kulyar, Muhammad Fakhar‐e‐Alam; Li, Rongrong; Mehmood, Khalid; Waqas, Muhammad; Li, Kun; Li, Jiakui

doi:10.1016/j.phymed.2020.153277

Cited by 67 publications

(60 citation statements)

References 80 publications

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“…Recently, studies have suggested the repurposing of curcumin [ 180 ], glycyrrhizin [ 181 ], thymoquinone [ 182 ], and polyphenolic flavonoids [ 183 ] for COVID-19 owing to their potential to exert synergistic or additive effects including antiviral, anti-inflammatory, immunomodulatory, and antioxidant activities, with no systemic toxicity. Although, the interaction and risks appear to have negligible therapeutic concern [ 184 ].…”

Section: Pharmaceutical Preparation and Drug Interactions Of mentioning

confidence: 99%

Can Echinacea be a potential candidate to target immunity, inflammation, and infection - The trinity of coronavirus disease 2019

Meeran¹,

Javed²,

Sharma³

et al. 2021

Heliyon

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Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing public health emergency. The pathogenesis and complications advanced with infection mainly involve immune-inflammatory cascade. Therefore, the therapeutic strategy relies on immune modulation, reducing infectivity and inflammation. Given the interplay of infection and immune-inflammatory axis, the natural products received attention for preventive and therapeutic usage in COVID-19 due to their potent antiviral and anti-immunomodulatory activities. Recently, Echinacea preparations, particularly E. purpurea, have been suggested to be an important antiviral agent to be useful in COVID-19 by modulating virus entry, internalization and replication. In principle, the immune response and the resultant inflammatory process are important for the elimination of the infection, but may have a significant impact on SARS-CoV-2 pathogenesis and may play a role in the clinical spectrum of COVID-19. Considering the pharmacological effects, therapeutic potential, and molecular mechanisms of Echinacea , we hypothesize that it could be a reasonably possible candidate for targeting infection, immunity, and inflammation in COVID-19 with recent recognition of cannabinoid-2 (CB2) receptors and peroxisome proliferator-activated receptor gamma (PPARγ) mediated mechanisms of bioactive components that make them notable immunomodulatory, anti-inflammatory and antiviral agent. The plausible reason for our hypothesis is that the presence of numerous bioactive agents in different parts of plants that may synergistically exert polypharmacological actions in regulating immune-inflammatory axis in COVID-19. Our proposition is to scientifically contemplate the therapeutic perspective and prospect of Echinacea on infection, immunity, and inflammation with a potential in COVID-19 to limit the severity and progression of the disease. Based on the clinical usage for respiratory infections, and relative safety in humans, further studies for the evidence-based approach to COVID-19 are needed. We do hope that Echinacea could be a candidate agent for immunomodulation in the prevention and treatment of COVID-19.

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Section: Pharmaceutical Preparation and Drug Interactions Of mentioning

confidence: 99%

Can Echinacea be a potential candidate to target immunity, inflammation, and infection - The trinity of coronavirus disease 2019

Meeran¹,

Javed²,

Sharma³

et al. 2021

Heliyon

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show abstract

“…Thus, the WHO has encouraged emerging countries to integrate the use of therapeutic plants as a supplementary resource to increase the effectiveness of the health care programs [ 1 , 2 ]. Among the evidence-based herbal remedies, highly ranked as a “miracle herb” is Nigella sativa (NS) [ 3 , 4 ] NS is a yearly blossoming plant from the family Ranunculaceae also known as black cumin, black seed, habbatul barakah, black caraway, kalojeera, kalonji or kalanji and is native to the southern regions of Asia and numerous countries in the Middle East and the Mediterranean region [ 4 , 5 , 6 ]. In historic and traditional medicine, NS has been utilized for centuries for the treatment of numerous illnesses of the body and psyche.…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

2020

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Thymoquinone (TQ), the chief active constituent of Nigella sativa (NS), shows very valuable biomedical properties such as antioxidant, antimicrobial, anticancer, anti-inflammatory, antihypertensive, hypoglycemic, antiparasitic and anti-asthmatic effects. Several studies have examined the pharmacological actions of TQ in the treatment of oral diseases but its potential role in periodontal therapy and regeneration is not yet fully defined. The present investigation has been designed to review the scientific studies about the effects of TQ as an adjunct to periodontal treatment to promote healing and periodontal regeneration. Along with clinical experiments, in vitro studies exhibit the beneficial effects of TQ during periodontal therapy. Nevertheless, additional comprehensive clinical and preclinical studies at cellular and molecular levels are essential to examine the particular action mechanisms of Nigella sativa and its elements, particularly TQ, during periodontal treatment or regeneration.

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“…[25][26][27] Moreover, Cinatl et al reported that glycyrrhizin elicited a significant antiviral activity against SARS coronavirus, 28 while Nigella sativa (black seed) was reported to have potential for the management of COVID-19 patients' symptoms. 13,[29][30][31] 33,34 Nigella sativa seeds thus offer a natural product with multiple potential pharmacological activities including antidiabetic, anticancer, immunomodulatory, analgesic, antimicrobial, anti-inflammatory, bronchodilator, renal and gastro-protective, and antioxidant properties. 35,36 Thymoquinone Thymoquinone (2-Isopropyl-5-methylbenzo-1, 4-quinone) is the main active ingredient of the volatile oil of black seed (Figure 1).…”

Section: Alternative Therapiesmentioning

confidence: 99%

Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure

Badary¹,

Hamza²,

Tikamdas³

2021

DDDT

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Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic

Cited by 67 publications

References 80 publications

Can Echinacea be a potential candidate to target immunity, inflammation, and infection - The trinity of coronavirus disease 2019

Can Echinacea be a potential candidate to target immunity, inflammation, and infection - The trinity of coronavirus disease 2019

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure

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