Potential Impact of Integrating the Sterile Insect Technique into the Fight against Disease-Transmitting Mosquitoes

Lees, Rosemary Susan; Carvalho, D. O.; Bouyer, Jérémy

doi:10.1201/9781003035572-33

Cited by 23 publications

(22 citation statements)

References 130 publications

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“…The PCA presented in this paper has been derived from operational AW-IPM programmes that include an SIT component in other insect models [30]. In addition, the recent knowledge acquired from ongoing small-scale field SIT trials against mosquitoes have been taken into account [25]. The proposal presents some similarities with the 'stages in development of a new vector-control product' scheme used by the WHO Vector Control Advisory Group (VCAG) that assesses the public health value of new vector-control interventions [54] starting from the laboratory (Phase I) via semi-field and small-scale field studies (Phase II) to largescale programmes (Phase III).…”

Section: Discussionmentioning

confidence: 99%

“…Among those methods, the sterile insect technique (SIT) (see Glossary) is an environment-friendly control method which has been used with great success against other insect pests; for example, the New World screwworm, Cochliomyia hominivorax, has been eradicated from Northern and Central America [7]; the tsetse fly Glossina austeni from Unguja Island, Zanzibar since 1997 [8]; the Mediterranean fruit fly, Ceratitis capitata, from Mexico and the programme is still ongoing to contain its reinvasion from Guatemala [9]; and the codling moth, Cydia pomonella, has been suppressed using SIT in British Columbia, Canada, for more than 25 years [10]. The development of SIT against mosquitoes has progressed rapidly in recent years with significant advances made with the development of genetic sexing strains [11-13], mass-rearing [14-19], sex separation [20,21], handling [22], radiation [23], quality control [24], and release technologies [25].…”

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Phased Conditional Approach for Mosquito Management Using Sterile Insect Technique

Bouyer

Yamada

Pereira

et al. 2020

Trends in Parasitology

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Mosquito-borne diseases represent a major threat to humankind. Recently, the incidence of malaria has stopped decreasing while that of dengue is increasing exponentially. Alternative mosquito-control methods are urgently needed. The sterile insect technique (SIT) has seen significant developments recently and may play an important role. However, testing and implementing SIT for vector control is challenging, and a phased conditional approach (PCA) is recommended, that is, advancement to the next phase depends on completion of activities in the previous one. We herewith present a PCA to test the SIT against mosquitoes within an area-wide-integrated pest-management programme, taking into account the experience gained with plant and livestock pests and the recent developments of the technique against mosquitoes.The Need for a PCA to Manage Mosquito Populations Using SIT According to the World Health Organization (WHO), 17% of infectious diseases are vectorborne, leading to more than 700 000 deaths annually [1]. Mosquitoes account for a large part of these diseases of which malaria, dengue, and Zika are the most devastating. After a period of success in global malaria control in the past decades, no significant progress was made in the period 2015-2017, with an estimated 219 million cases in 2017, due to various threats including the spread of insecticide resistance of the mosquitoes hampering current control strategies [1]. In addition, dengue incidence has increased dramatically, with yearly new infections estimated at 390 million. Zika epidemics in 2015-2016 had dramatic effects in Latin America, and this disease still poses a major threat to human health [2]. Increased concerns about the impact of insecticides on living organisms and ecosystems is driving a growing number of countries to reduce the number of approved active chemicals and overall broad-spectrum insecticide outdoor applications. The resistance of mosquitoes to pyrethroids, the most commonly used class of insecticides, continues to increase. The WHO expresses the urgent need for alternative mosquito-control methods that should be added to existing tools, particularly against Aedes spp. [3].Many alternative methods are being tested [4][5][6]. Among those methods, the sterile insect technique (SIT) (see Glossary) is an environment-friendly control method which has been used with great success against other insect pests; for example, the New World screwworm, Cochliomyia hominivorax, has been eradicated from Northern and Central America [7]; the tsetse fly Glossina austeni from Unguja Island, Zanzibar since 1997 [8]; the Mediterranean fruit fly, Ceratitis capitata, from Mexico and the programme is still ongoing to contain its reinvasion from Guatemala [9]; and the codling moth, Cydia pomonella, has been suppressed using SIT in British Columbia, Canada, for more than 25 years [10]. The development of SIT against mosquitoes has progressed rapidly in recent years with significant advances made with the development of genetic sexing strains [11-13], mass-re...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Phased Conditional Approach for Mosquito Management Using Sterile Insect Technique

Bouyer

Yamada

Pereira

et al. 2020

Trends in Parasitology

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“…SIT is a method of insect control with a strong record of successful applications against a range of agricultural insect pests [ 14 , 15 ]. The limitations of current vector control strategies especially in areas with mosquito-borne diseases [ 16 , 17 ] and the availability of new equipment that supports the implementation of SIT (e.g., mass-rearing cages for adults and racks for larvae, sex sorters, automatic release systems by drones) [ 18 , 19 ] have sparked interest in utilizing this approach. Pilot SIT field trials conducted against Ae.…”

Section: Introductionmentioning

confidence: 99%

Reduction in Egg Fertility of Aedes albopictus Mosquitoes in Greece Following Releases of Imported Sterile Males

Balatsos

Puggioli

Karras

et al. 2021

Insects

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Aedes albopictus, an invasive mosquito species, is currently well established in many European countries, posing high risks to human health. A preliminary trial using repetitive releases of irradiated sterile male mosquitoes was designed, implemented and evaluated for the first time in Greece. The main scope of this trial was to investigate the efficacy of sterile insect technique (SIT) on wild population egg hatch rate in Greece using mass-produced sterile male mosquitoes from another country (Italy). The study was conducted in Vravrona area, close to Athens International Airport (Attica Region). The number of eggs laid in ovitraps was similar in all intervention and control plots. However, a significant reduction in egg hatch rate was recorded in the SIT plot in comparison with both control plots starting two weeks after the first release. This trial validates the logistics (transportation, releases handling and monitoring) as a major step towards implementing efficient, environmentally safe control approaches as an additional tool against the invasive Aedes species in Greece and more widely in Europe.

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“…CC-BY-NC-ND 4.0 International license perpetuity. It is made available under a preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in The copyright holder for this this version posted September 26, 2020. ; https://doi.org/10.1101/2020.09.25.313544 doi: bioRxiv preprint very successfully against various agricultural pests (Wyss 2006, Enkerlin et al 2015 and vectors (Dicko et al 2014, Vreysen et al 2000, and has been under development for several years against disease transmitting mosquitoes with major progresses reported recently (Lees et al 2020). Thirty four pilot SIT trials against mosquitoes are reported as presently ongoing worldwide (Bouyer et al 2020a).…”

Section: Introductionmentioning

confidence: 99%

Field Competitiveness of Aedes albopictus (Diptera: Culicidae) Irradiated Males in Pilot Sterile Insect Technique Trials in Northern Italy

Bellini

Carrieri

Balestrino

et al. 2020

Journal of Medical Entomology

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Vector-borne diseases account for 17% of infectious diseases, leading to more than one million deaths each year. Mosquitoes are responsible for 90% of the casualties and alternative control methods to insecticides are urgently needed, especially against Aedes vectors. Aedes albopictus is a particularly important species, causing major public health problems because it is a vector of several arboviruses and has a strong invasive behavior. Various genetic control methods have been proposed to be integrated into the management strategies of Aedes species, among which the sterile insect technique (SIT), which proved efficient against various insect pests and vectors. However, the ability of released irradiated sterile male mosquitoes to compete with their wild counterparts and induce sterility in wild females, which is critical to the success of this strategy, remained poorly defined. Here, we assessed the field competitiveness of Ae. albopictus irradiated male using data from eight release trials implemented in Northern Italy for 3 yr. Sterile males were capable of inducing a good level of sterility in the wild female population, however, with high variability in time and space. The field competitiveness of the released males was strongly negatively correlated with the ratio of sterile to wild males. This should be taken into consideration when designing future programs to suppress field populations of Aedes mosquitoes.

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Potential Impact of Integrating the Sterile Insect Technique into the Fight against Disease-Transmitting Mosquitoes

Cited by 23 publications

References 130 publications

Phased Conditional Approach for Mosquito Management Using Sterile Insect Technique

Phased Conditional Approach for Mosquito Management Using Sterile Insect Technique

Reduction in Egg Fertility of Aedes albopictus Mosquitoes in Greece Following Releases of Imported Sterile Males

Field Competitiveness of Aedes albopictus (Diptera: Culicidae) Irradiated Males in Pilot Sterile Insect Technique Trials in Northern Italy

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