Potential impact of functional biomolecules-enriched foods on human health: A randomized controlled clinical trial

Abstract

Naturally occurring milk compounds have recently been investigated for their health-promoting properties; in fact, their anti-microbial, immuno-modulatory, antioxidant and anti-thrombotic activities, have increasingly gained interest within the scientific community. We have reported a translational, randomized, controlled clinical trial (RCT) on human subjects with a moderate to high cardiovascular risk, and a body mass index (BMI) >25.1 kg/m2, to evaluate the clinical impact of biomolecules-enriched Mediterranean Buffalo (Bubalus bubalis) milk and its derived dairy foods, produced with innovative breeding techniques. The experimental arm involved patients that followed a diet including the above-described products (treated group; n= 11); the control arm was based on a diet including cow milk and its dairy products (control group; n= 9). The results of this study have been statistically evaluated, pointing out a specific significance related to the comparative analysis of the blood pressure among the 2 arms; in fact, this value showed a significant improvement in an extremely short experimental time. Nevertheless, this study also reported not-significant results that were indicative of an interesting and promising tendency in modulating specific diet-depending haematological and biomedical values. In conclusion, this RCT has assessed that the foods derived from buffalo milk naturally enriched with biomolecules, was able to improve the overall blood glucose levels, the BMI and the body weight. These preliminary results are suitable for the design of future strategies in the prevention of cardiometabolic diseases, thus improving the overall quality of life and the policies of healthcare management.

SIRT3 Modulates Endothelial Mitochondrial Redox State during Insulin Resistance

“…In the contest of emerging epigenetic modulators, several studies have demonstrated the effects of the natural antioxidant δ-valerobetaine (δVB), N , N , N -trimethyl-5-aminovaleric acid [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ], a water-soluble trimethylated compound originating from a specific transformation of Nε-trimethyllysine [ 24 , 25 ]. Experimental studies suggest that δVB has great potential in the prevention of diabetes and its vascular complications, with many effects occurring through the modulation of the epigenetic regulators, SIRT1 and SIRT6 [ 16 , 17 , 18 , 19 ].…”

The milk IGF-2 level is positively correlated with milk yield in Anatolian water buffaloes

“…There is increasing interest in research in buffalo milk due to its bioactive substance content and health benefits. As the therapeutic potential of the bioactive compounds in buffalo milk is proven, interest in buffalo milk is increasing all over the world (Colarow et al, 2003;Servillo et al, 2018;D'Onofrio et al, 2019;Tatullo et al, 2022). Compared with fermented cow's milk products, those made with buffalo milk have been found to show better bacterial viability in vitro gastrointestinal digestion, and buffalo milk has been reported to have a potential protective effect on the human microbiome (da Silva et al, 2020).…”

Feasibility study on the use of “Qi-tonifying medicine compound” as an anti-fatigue functional food ingredient based on network pharmacology and molecular docking

“…Compared with conventional drugs, functional foods have a higher safety profile and higher adherence. The functional foods market has rapidly increased, attracting attention from consumers and merchants (12). Thus, designing novel functional foods has become a topic of focus.…”