Potential immunomodulatory activity of bovine casein hydrolysates produced after digestion with proteinases of lactic acid bacteria

Stuknytė, Milda; Noni, Ivano De; Guglielmetti, Simone; Minuzzo, Mario; Mora, Diego

doi:10.1016/j.idairyj.2011.04.011

Cited by 34 publications

(26 citation statements)

References 41 publications

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“…So, it is reasonable to think that many of these bioactive peptides can be produced also during the ripening of Parmigiano Reggiano and Grana Padano, mainly by lactic acid bacteria starters (15,16). In fact, one of the very specifi c species of whey starters used for Grana Padano and Parmigiano Reggiano, Lactobacillus helveticus, is one of the species mainly responsible for the formation of these bioactive compounds (17,18). Some studies (19,20) have investigated the formation of peptides in Parmigiano Reggiano and Grana Padano cheese and/or their digested products in vitro; however, this topic needs to be studied further, with particular emphasis on biopeptide formation.…”

Section: Bioactive Peptides: General Descriptionmentioning

confidence: 99%

Cheese as Functional Food: The Example of Parmigiano Reggiano and Grana Padano

Summer

Formaggioni

Franceschi

et al. 2017

Food Technol. Biotechnol.

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SummaryItalian hard cooked types of cheese, like Parmigiano Reggiano and Grana Padano, are characterised by positive nutritional qualities. In fact, they contain substances that have particular biological activities, and therefore they can be fully considered, according to the defi nition given by the European Unit, as 'functional' foods. This short review concisely describes these components and the benefi cial eff ects related to their activities. The description of the biologically active components has been organised in the following paragraphs: protein and peptides, fat and lipids, carbohydrates and prebiotics, probiotic bacteria, vitamins, mineral salts, and components of dairy products active in disease prevention. In particular, several known bioactive peptides were found in Parmigiano Reggiano cheese samples: for example, phosphopeptides, which are known for their mineral-binding capacity and vehiculation activity, peptides with immunomodulatory activity, and angiotensin-converting enzyme-inhibitory peptides with anti-hypertensive eff ects. Among lipids, the role of conjugated linoleic acid and other fatt y acids present in these cheese types was taken into consideration. The presence of oligosaccharides with prebiotic properties and probiotic bacteria was also described. Finally, particular emphasis was given to highly available calcium and its impact on bone health.

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Section: Bioactive Peptides: General Descriptionmentioning

confidence: 99%

Cheese as Functional Food: The Example of Parmigiano Reggiano and Grana Padano

Summer

Formaggioni

Franceschi

et al. 2017

Food Technol. Biotechnol.

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“…Stimulation was conducted both in the presence and the absence of 2 ng/ml of IL-1␤. After incubation at 37°C for 4 h, the samples were treated and the bioluminescence was measured as described previously (16). All conditions were analyzed in triplicate in at least two independent experiments.…”

Section: Methodsmentioning

confidence: 99%

Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response

Turroni

Taverniti

Ruas‐Madiedo

et al. 2014

Appl Environ Microbiol

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e Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NF-B activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host.

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“…Fragments of casein polypeptide chain sequences containing phosphoserine residues participate in the transport and absorption of Ca +2 ions. The following major categories of bioactive peptides have been derived from milk proteins: antihypertensive, antithrombotic, opioid, casein phosphopeptides, antimicrobial, cytomodulatory, immunomodulatory and other , Korhonen and Pihlanto 2006, Mils et al 2011, Phelan et al 2009, Stuknyte et al 2011. …”

Section: Profiles Of Potential Biological Activity Of Milk Proteinsmentioning

confidence: 99%

“…Assays aiming to determine the immunomodulatory properties of peptides have to account for a variety of factors (susceptibility to digestion in the gastrointestinal tract, peptides' effect on the mucosal immune system, toxicity), therefore, they often deliver controversial results. Most studies investigating the immunomodulatory properties of peptides evaluate their infl uence on lymphocyte activity and proliferation, cytokinin secretion and the production of antibodies [Durrieu et al 2006, Stuknyte et al 2011.…”

Section: Strategy For Isolating and Analysing Bioactive Peptidesmentioning

confidence: 99%

Milk proteins-derived bioactive peptides in dairy products: molecular, biological and methodological aspects

Dziuba

2014

Acta Sci Pol Technol Aliment

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Proteins are one of the primary components of the food, both in terms of nutrition and function. They are main source of amino acids, essential for synthesis of proteins, and also source of energy. Additionally, many proteins exhibit specifi c biological activities, which may have effect on functional or pro-health properties of food products. These proteins and their hydrolysis products, peptides, may infl uence the properties of food and human organism. The number of commercially available food products containing bioactive peptides is very low, apart from that milk proteins are their rich source. It could be supposed that number of available products with declared activity will rise in near future because of observed strong uptrend on interest in such products. Molecular and biological properties of milk proteins, as precursors of bioactive peptides was characterised in the work. Therefore, the strategy of research and obtaining of such peptides both in laboratory and industrial scale, as well as the range of their commercial application, was presented. Several examples of research efforts presenting high potential to develop new products containing bioactive peptides from milk proteins and predetermined as nutraceuticals was described.

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Potential immunomodulatory activity of bovine casein hydrolysates produced after digestion with proteinases of lactic acid bacteria

Cited by 34 publications

References 41 publications

Cheese as Functional Food: The Example of Parmigiano Reggiano and Grana Padano

Cheese as Functional Food: The Example of Parmigiano Reggiano and Grana Padano

Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response

Milk proteins-derived bioactive peptides in dairy products: molecular, biological and methodological aspects

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