Potential Immune Modulatory Action of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Type 1 Diabetes

Carpanetto, Andrea; Gai, Chiara; Favaro, Enrica; Zanone, Maria M.

doi:10.23937/2469-570x/1410011

Cited by 2 publications

(1 citation statement)

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“…This contention is supported by the production of bioactive soluble factors known to inhibit apoptosis and fibrosis, enhance angiogenesis, stimulate mitosis and/or differentiation of tissue-intrinsic progenitor cells 10 and modulate the immune response. 6 MSC-secreted bioactive molecules acting as paracrine or endocrine mediators that directly activate target cells and/or cause neighboring cells to secrete functionally active agents. It has recently been demonstrated that extracellular vesicles or microvesicles (MVs) released from cells are an integral component of the cell-to-cell communication network involved in tissue regeneration, 10 , 18 and therefore may contribute to the paracrine action of MSCs.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Mesenchymal Stem Cell Derived Microvesicles in Repair of Femoral Chondral Defects in Dogs

Sabry

Shamaa

Amer

et al. 2018

J. Musculoskelet. Res.

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Mesenchymal stem cells (MSCs) releases in culture extracellular vesicles called microvesicles (MVs). MVs have beneficial cytokines that prevent progression of the disease and help in the regeneration process. This study is aimed to evaluate the effect of MSCs derived MVs in repair of induced chondral defect in a dog model. Methods: Chondral defects were created surgically (3 mm Â 1 mm) in both femoral condyles of nine dogs, autologous MSCs were isolated and MVs were prepared and injected Correspondence to: intraarticularly in the right joint. The left joint was injected with normal saline as control negative. Evaluation of the treatment after first injection was carried out by physical examination and histopathology at different time periods (1½, 3 and 6 months). Results: Treated joints showed marked degree of cartilage regeneration and restoration of chondral histomorphological picture on the contrary of the control joints that showed deterioration over time and defect filling with only fibrous tissue forming a fibrocartilage at the end of six months period. Conclusion: We demonstrated in this study that administration of MVs was effective on the functional and morphological recovery of the injured cartilage and could be exploited as a cell free therapeutic approach in regenerative medicine.

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Section: Introductionmentioning

confidence: 99%