Potential Imaging Biomarkers of Cognitive Frailty

Park, Jaesub; Kim, Woo Jung

doi:10.4235/agmr.22.0141

Cited by 3 publications

(2 citation statements)

References 45 publications

(63 reference statements)

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“…Several studies have demonstrated the association between hypertension, white matter lesions, and cognitive decline. 17,18) Cognitive decline and VLOSLP are more strongly associated with periventricular white matter hyperintensities than with subcortical brain infarctions on magnetic resonance imaging (MRI). 2,3,18) Additionally, several studies have suggested an association between estrogenic receptor polymorphisms and vascular cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Very Late-Onset Schizophrenia-Like Psychosis: A Case Report and Critical Literature Review

Regala¹,

Moniz-Pereira²

2023

Ann Geriatr Med Res

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Late-life psychosis presents a challenge, wherein a wide range of differential diagnoses should be considered. Very late-onset schizophrenia-like psychosis (VLOSLP) is a nosological entity that remains a conundrum. We provide a comprehensive literature review on the neurobiological underpinnings of VLOSLP. We describe a case that typifies the clinical presentation of VLOSLP. Although not pathognomonic, certain features, namely the two-stage progression of psychotic episode, partition delusions, multimodal hallucinations, and absent formal thought disorder or negative symptoms, are quite suggestive of VLOSLP. Several medical causes that might cause late-life psychosis, including neuroinflammatory/immunology diseases, were ruled out. Neuroimaging revealed basal ganglia lacunar infarctions along with chronic white matter small-vessel ischemic disease. The diagnosis of VLOSLP is based on clinical evidence, and the aforementioned clinical features support this diagnostic hypothesis. This case adds to the growing body of evidence pertaining to the relevance of cerebrovascular risk factors in the pathophysiology of VLOSLP, alongside age-specific neurobiological processes. We hypothesized that microvascular brain lesions disrupt the frontal-subcortical circuitry and uncover other core neuropathological processes. Future research should focus on identifying a specific biomarker that would allow clinicians to more accurately diagnose VLOSLP, differentiate it from other overlapping clinical entities such as dementia or post-stroke psychosis, and provide a tailored treatment for the patient.

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Section: Discussionmentioning

confidence: 99%

Very Late-Onset Schizophrenia-Like Psychosis: A Case Report and Critical Literature Review

Regala¹,

Moniz-Pereira²

2023

Ann Geriatr Med Res

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“…De igual modo, predice la enfermedad cardiovascular [ 15 , 16 ]. Un estudio reciente muestra una posible asociación de este síndrome con anomalías de la sustancia blanca (hiperintensidad de la sustancia blanca y microsangrados), así como una disminución del volumen de la corteza cerebral/cerebelosa [ 17 ].…”

Section: Fragilidad Y Enfermedades Neurológicas: Implicación En La Pr...unclassified

Concepto y manejo práctico de la fragilidad en neurología

Cristofori¹,

Aguado-Ortego²,

Gómez-Pavón³

2023

RevNeurol

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La fragilidad se entiende como un situación clínica de disminución de la reserva homeostática que, ante un desencadenante (enfermedad aguda, caída, toma de un fármaco…), aumenta el riesgo de un evento adverso, como ingreso hospitalario, en residencia, deterioro funcional y/o cognitivo, muerte, etc. La fragilidad puede entenderse como fragilidad física, fenotipo de Fried, verdadero síndrome geriátrico, que puede ser reversible evitando su progresión a estadios más avanzados de irreversibilidad y de dependencia, y fragilidad por acúmulo de déficits de Rockwood, como continuum de salud o tipología de clasificación del anciano a lo largo del espectro de la fragilidad (sano, robusto, vulnerable, fragilidad leve-moderada-grave y extrema o final de vida). El diagnóstico de fragilidad física forma parte de la valoración geriátrica integral y se recomienda para su diagnóstico utilizar un test de ejecución, como velocidad de la marcha (<0,8 m/s), Timed Up and Go (>12 segundos) o Short Physical Performance Battery (<10). La fragilidad física es reversible basándose en un tratamiento multidisciplinar sobre tres pilares fundamentales: ejercicio físico multicompetente y contra resistencia, aporte adecuado de proteínas y micronutrientes (leucina, vitamina D, etc.), y adecuada prescripción farmacológica, de tratamiento de comorbilidad y de síndromes geriátricos. La fragilidad es un factor de riesgo de progresión de la enfermedad neurológica y de mayor riesgo de evento adverso tanto en enfermedades neurodegenerativas, como el deterioro cognitivo leve, la demencia o la enfermedad de Parkinson, como en la enfermedad cerebrovascular. La fragilidad a través de la Clinical Frailty Scale o el VIG-Frail muestra tipologías de pacientes en relación con un mayor o menor estado de fragilidad, y es una herramienta básica pronóstica de gran utilidad en la toma de decisiones de manejo diagnóstico y terapéutico. Se abre una nueva oportunidad de mejora en el manejo de la enfermedad neurológica ante el diagnóstico y el tratamiento de la fragilidad.

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Syndrome frailty and his features in Parkinson’s disease

Guseva

2024

Bûll. sib. med.

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Syndrome frailty is widespread all over the world and its appearance is associated with an increase in life expectancy. The lecture shows the multifactorial nature of the syndrome: changes in physical health, social and psychological factors, gender characteristics and age. The classic diagnosis of the syndrome consists in assessing physical weakness according to the Fried phenotype. The modern view of the problem complements the diagnosis with indices of weakness to characterize the multifactorial development and the use of digital wearable technologies for long-term monitoring of the patient’s functional parameters.The lecture provides a detailed justification of the effect of comorbidity on the development of syndrome frailty. The syndrome frailty is difficult diagnosed in Parkinson’s disease, because it has high prevalence in these. Studies of syndrome frailty in Parkinson’s disease are few, probably due to the similarity of the symptoms of the disease and the syndrome. The lecture identifies the possible risks of syndrome frailty in Parkinson’s disease: the influence of various forms of Parkinson’s disease, gender, cognitive and functional disorders, polypharmacy, levodopa doses. The role of multidisciplinary rehabilitation’s team and independent physical activity in the combination of Parkinson’s disease and syndrome frailty is shown.

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Potential Imaging Biomarkers of Cognitive Frailty

Cited by 3 publications

References 45 publications

Very Late-Onset Schizophrenia-Like Psychosis: A Case Report and Critical Literature Review

Very Late-Onset Schizophrenia-Like Psychosis: A Case Report and Critical Literature Review

Concepto y manejo práctico de la fragilidad en neurología

Syndrome frailty and his features in Parkinson’s disease

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