Potential Health Benefits of Curcumin on Female Reproductive Disorders: A Review

Kamal, Datu Agasi Mohd; Salamt, Norizam; Yusuf, Allia Najmie Muhammad; Kashim, Mohd Izhar Ariff Mohd; Mokhtar, Mohd Helmy

doi:10.3390/nu13093126

Cited by 31 publications

(26 citation statements)

References 89 publications

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“…[41] Previous studies show reduced organ index weight of thymus and spleen post-treatment with curcumin and piperine. [42][43] All the treatment groups were a significant change in reducing the organ weight index of the thymus and spleen. Histopathology studies showed changes in tissue associated with the disease.…”

Section: Discussionmentioning

confidence: 96%

Evaluation of Curcumin, Piperine, and Ferrous Sulphate Combination Potential in the Adjuvant-induced Arthritis Model in Male Wistar Rats

Thakkar¹,

Bhatia²,

Doshi³

2022

Pharmacogn. Res.

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Background: Rheumatoid arthritis (RA) is an autoimmune disorder known for prolonged joint inflammation and deformity condition. Currently, Complementary and alternative medicine (CAM) treatment in RA patients is preferred. Objectives: The research focuses on exploring the combination (curcumin (200mg/kg), piperine (10mg/kg), and ferrous sulphate (0.1mg/kg) potential in the adjuvant-induced arthritis model (AIA) compared with disease control and prednisone acetate (standard 5 mg/kg) in the adjuvant-induced arthritis model (AIA). Materials and Methods: Male Wistar rats in each group was treated with standard, curcumin, piperine, and ferrous sulphate individually as well as in combination for 28 days after the induction of arthritis. Evaluation parameters were body weight, paw edema, mobility condition, and stair climbing test. Furthermore, Red Blood Cells (RBCs), White Blood Cells (WBCs), immune organ index (spleen and thymus) was elucidated. The study was concluded with histopathology, X-ray radiography, Tumour Necrosis Factor α (TNF α), and Interleukin-1beta (IL-β) examination. Results: The combination showed significance with the gradual increase in body weight and mobility (7 th day), whereas the conditions of paw edema and stair climbing were found effective (28 th day). RBC and WBC counts were found to be clinically significant. The combination was found to be highly significant in estimation of immune organ index. Combination showed significant change in infiltration of inflammatory cells, joint space, and minimal erosion in bone indicating satisfactory anti-arthritic effects. Furthermore, the combination showed improvement in joint radiodensity and narrowing in joint space. The level of TNF-α and IL-1β were found significant. Conclusion: The combination showed antiinflammatory and anti-arthritic activity.

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Section: Discussionmentioning

confidence: 96%

Evaluation of Curcumin, Piperine, and Ferrous Sulphate Combination Potential in the Adjuvant-induced Arthritis Model in Male Wistar Rats

Thakkar¹,

Bhatia²,

Doshi³

2022

Pharmacogn. Res.

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“…Animal studies have shown how cucurmin can have a therapeutic potential against endometriosis by decreasing certain cytokines and having antiangiogenic effects. 40,41 The benefits of turmeric that patients with endometriosis see are not well described in the literature. While effects have not been well studied there are no harmful side effects seen with turmeric supplementation.…”

Section: Turmericmentioning

confidence: 99%

Complementary therapy for endometriosis related pelvic pain

Lou

Chu

et al. 2023

Journal of Endometriosis and Pelvic Pain Disorders

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In the setting of a global pandemic, it is vastly important now more than ever that patients have agency and control over pain management when living with a debilitating chronic pain disease such as endometriosis. We present a review of the available literature on the most popular and easily accessible complementary pain management therapies for endometriosis including Transcutaneous Electrical Nerve stimulator (TENS) units, diets, Cannabidiol (CBD), turmeric, meditation, yoga, and acupuncture. These are worthwhile recommendations; however, the data for each is limited and more research is needed to further support each of its use.

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“…Curcuma longa L.-Curcumin Curcumin is a yellow pigment and an active component of the rhizome of Curcuma longa L., or turmeric [167]. It is known to possess antioxidant, anti-inflammatory, anti-cancer, anti-arthritis, anti-asthmatic, antimicrobial, antiviral and antifungal properties [167,168]. Considering that curcumin is a powerful antioxidant natural compound, it may represent another potential treatment to alleviate oxidative stress in glaucoma.…”

Section: Crocus Sativus L-crocetin and Crocinmentioning

confidence: 99%

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

et al. 2022

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Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by increased intraocular pressure, which results in damage of the optic nerve and retinal ganglion cells, ultimately leading to visual field dysfunction. However, even with the use of intraocular pressure-lowering eye drops, the disease still progresses in some patients. In addition to mechanical and vascular dysfunctions of the eye, oxidative stress, neuroinflammation and excitotoxicity have also been implicated in the pathogenesis of glaucoma. Hence, the use of natural products with antioxidant and anti-inflammatory properties may represent an alternative approach for glaucoma treatment. The present review highlights recent preclinical and clinical studies on various natural products shown to possess neuroprotective properties for retinal ganglion cells, which thereby may be effective in the treatment of glaucoma. Intraocular pressure can be reduced by baicalein, forskolin, marijuana, ginsenoside, resveratrol and hesperidin. Alternatively, Ginkgo biloba, Lycium barbarum, Diospyros kaki, Tripterygium wilfordii, saffron, curcumin, caffeine, anthocyanin, coenzyme Q10 and vitamins B3 and D have shown neuroprotective effects on retinal ganglion cells via various mechanisms, especially antioxidant, anti-inflammatory and anti-apoptosis mechanisms. Extensive studies are still required in the future to ensure natural products’ efficacy and safety to serve as an alternative therapy for glaucoma.

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Potential Health Benefits of Curcumin on Female Reproductive Disorders: A Review

Cited by 31 publications

References 89 publications

Evaluation of Curcumin, Piperine, and Ferrous Sulphate Combination Potential in the Adjuvant-induced Arthritis Model in Male Wistar Rats

Evaluation of Curcumin, Piperine, and Ferrous Sulphate Combination Potential in the Adjuvant-induced Arthritis Model in Male Wistar Rats

Complementary therapy for endometriosis related pelvic pain

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

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