Potential Geographic Distribution of Hantavirus Reservoirs in Brazil

Oliveira, Stefan Vilges de; Escobar, Luis E.; Peterson, A. Townsend; Gurgel-Gonçalves, Rodrigo

doi:10.1371/journal.pone.0085137

Cited by 38 publications

(37 citation statements)

References 40 publications

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“…Some hantavirus species are linked with HFRS and others with HPS, each with specifi c environmental scenarios and climate patterns. In the rural areas of the DF, the reservoir for hantavirus transmission is the wild rodent Necromys lasiurus (15) (16) (17) .…”

Section: Introductionmentioning

confidence: 99%

Ten years of a hantavirus disease emergency in the Federal District, Brazil

Dusi

Bredt

Freitas

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction: Hantavirus diseases are emerging human diseases caused by Hantavirus spp. of the Bunnyaviridae family. Hantavirus pulmonary syndrome (HPS) has been detected in the Federal District (DF) of Brazil since 2004. Among the 27 Brazilian Federal Units, DF has the highest fatality rate. More than 10 years have already passed since then, with confi rmation of cases caused by the Araraquara and Paranoa species. The reservoir is Necromys lasiurus. Methods: Local surveillance data of the confi rmed cases were analyzed, including age, sex, month and year of occurrence, clinical symptoms, syndromes and outcomes, and probable transmission place (PTP). The cases were mainly confi rmed by IgM detection with a capture enzyme immunoassay. The cases were classifi ed as autochthonous if PTPs were in the DF area. Results: From 2004 to 2013, in the DF, 126 cases of hantavirus were confi rmed, and the cumulative incidence was 5.0 per 100,000 inhabitants. The occurrence of cases was predominantly from April to August. At least 75% of the cases were autochthonous. Acute respiratory failure was reported in 47.5% of cases, and the fatality rate was 40%. Conclusions: In the DF, the cumulative incidence of HPS was one of the highest worldwide. A seasonal pattern of hantavirus disease in the dry season is clear. There was a high frequency of severe clinical signals and symptoms as well as a high fatality rate. For the near future, visitors and inhabitants of DF rural areas, particularly male adults, should receive continuous education about hantavirus transmission and prevention.

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Section: Introductionmentioning

confidence: 99%

Ten years of a hantavirus disease emergency in the Federal District, Brazil

Dusi

Bredt

Freitas

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…In Brazil, the first occurrence of HPS was reported in 1993 in the city of Juquitiba, in the state of Sao Paulo [4]. Since then, knowledge of the disease has been growing parallel to its range in Brazil; the presence of the disease has been established in all regions of the country [5,6]. HPS is a notifiable disease for the Brazilian Ministry of Health and its importance for public health is due to the high case-fatality rates (~ 40%) and limited knowledge about its epidemiology [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Is an omnivorous and terrestrial species which feeds mainly on seeds [6]. Is widely distributed within the Brazilian Cerrado and Caatinga biomes, areas where human land use and modification of the natural environment are widespread.…”

Section: Introductionmentioning

confidence: 99%

“…Most HPS cases in Brazil occurred in areas with the presence of this rodent. Can be found in many habitats, but prefer open and dry areas, being absent or infrequent in moist forest environments [6]. A number of studies have indicated that regional distributions of host and pathogens are associated with climatic and environmental factors [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Does Land Cover Influence the Spatial Distribution of Reservoir Rodent Necromys Lasiurus?

Santos¹

2017

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The rodent Necromys lasiurus (Rodentia, Sigmodontinae) is considered to be the main hantavirus reservoir in the Brazilian Cerrado biome. Significant changes to the landscape of this biome have occurred in recent decades. Considering the fact that change in land use patterns can influence species distribution and, as a result, the emergence of diseases, this study sought to analyze the potential geographic distribution of the species N. lasiurus and to understand how land use and occupation contribute to the distribution of this species. Using Ecological Niche Modeling (ENM), environmental suitability models were constructed for N. lasiurus. The Maxent algorithm was used with predictor variables indicated by the results of the jackknife technique. Test accuracy was evaluated using the area under the curve (AUC). The differences in the potential distribution models resulting from the inclusion or exclusion of land use as a variable were not random (p < 0.0001). The jackknife method indicated that the variables referred to as percentage of vegetation cover and land use are the strongest predictive models (38.9% and 37.9%, respectively). The AUC evaluation indicated good performance (0.93 and 0.92). When inserted into the model, the variables land use and vegetation cover were found to significantly influence potential N. lasiurus distribution. These variables should be considered when predicting the occurrence of this medically important rodent.

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“…The most prevalent viral variants of hantavirus are Juquitiba, which occurs in wild rodents living in the Atlantic Forest region; Araraquara, which occurs in wild rodents from the cerrado and caatinga biomes (typical Brazilian vegetation) 10 ; Castelo dos Sonhos, which is present in rodents living in the cerrado and Amazon Rainforest; and Anajatuba, which has been found in wild rodents living in the Amazon Rainforest and fl ooded regions 11 . In Brazil, hantavirosis manifests as hantavirus cardiopulmonary syndrome (HCPS), and the primary symptoms include fever, myalgia, flank and abdominal pain, severe cephalgia, nausea, vomiting and diarrhea; unfortunately, these unspecifi c symptoms can be confused with many other diseases 11,12 .…”

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confidence: 99%