Potential Genes Associated with COVID-19 and Comorbidity

Feng, Shanshan; Song, Fu-Qiang; Guo, Wenqiong; Tan, Jishan; Zhang, Xianqin; Qiao, Fengling; Guo, Jinlin; Zhang, Lin; Xu, Jia

doi:10.7150/ijms.67815

Cited by 31 publications

(29 citation statements)

References 124 publications

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“…It thus takes older individuals longer to resolve immune system activation 124 and cytokine release is heightened in older age. 125 This view is also consistent with reports that gene loci associated with non-resolving inflammation 126 , 127 constitute a genetic risk for severe COVID-19. At the same time, aged cells exhibit weakened viral defenses with decreases in the IFN response 128 - 130 ( Figures 1 – 3 ).…”

Section: Part 1: the Problemsupporting

confidence: 90%

COVID-19 Spotlights Connections between Disease and Multiple Lifestyle Factors

Enichen

Harvey

Demmig-Adams

2022

American Journal of Lifestyle Medicine

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The SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2), and the disease it causes (COVID-19), have had a profound impact on global human society and threaten to continue to have such an impact with newly emerging variants. Because of the widespread effects of SARS-CoV-2, understanding how lifestyle choices impact the severity of disease is imperative. This review summarizes evidence for an involvement of chronic, non-resolving inflammation, gut microbiome disruption (dysbiosis with loss of beneficial microorganisms), and impaired viral defenses, all of which are associated with an imbalanced lifestyle, in severe disease manifestations and post-acute sequelae of SARS-CoV-2 (PASC). Humans’ physiological propensity for uncontrolled inflammation and severe COVID-19 are briefly contrasted with bats’ low propensity for inflammation and their resistance to viral disease. This insight is used to identify positive lifestyle factors with the potential to act in synergy for restoring balance to the immune response and gut microbiome, and thereby protect individuals against severe COVID-19 and PASC. It is proposed that clinicians should consider recommending lifestyle factors, such as stress management, balanced nutrition and physical activity, as preventative measures against severe viral disease and PASC.

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Section: Part 1: the Problemsupporting

confidence: 90%

COVID-19 Spotlights Connections between Disease and Multiple Lifestyle Factors

Enichen

Harvey

Demmig-Adams

2022

American Journal of Lifestyle Medicine

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“…Similarly, a significantly higher CCR5-Δ32 frequency was observed in symptomatic SARS-CoV-2 positive patients compared to COVID-19 asymptomatic subjects. Moreover, these researchers found that CCR5 deletion may predict the severity of SARS-CoV-2 infection [ 4 ]. Thus, countries with a higher CCR5-Δ32 frequency showed the highest viral infection and COVID-19 mortality rates [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…During the first wave of infection, Italy had one of the highest numbers of SARS-CoV-2 related contagions and one of the highest mortality rates. Across the world, the most severe clinical course of COVID-19 has been associated with old age, comorbidities, and male gender [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Polymorphisms in the TMPRSS2 gene were analyzed regarding their involvement in SARS-CoV-2 infection, and some common variants seem to modulate TMPRSS2 expression, allowing a mild-to-moderate effect in infection susceptibility [ 4 , 18 ]. Genetic variants related to reduced TMPRSS2 expression may confer less individual susceptibility to infection with a better disease outcome.…”

Section: Introductionmentioning

confidence: 99%

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Allelic Variations in the Human Genes TMPRSS2 and CCR5, and the Resistance to Viral Infection by SARS-CoV-2

Vitello

Federico

Bruno

et al. 2022

IJMS

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During the first wave of COVID-19 infection in Italy, the number of cases and the mortality rates were among the highest compared to the rest of Europe and the world. Several studies demonstrated a severe clinical course of COVID-19 associated with old age, comorbidities, and male gender. However, there are cases of virus infection resistance in subjects living in close contact with infected subjects. Thus, to explain the predisposition to virus infection and to COVID-19 disease progression, we must consider, in addition to the genetic variability of the virus and other environmental or comorbidity conditions, the allelic variants of specific human genes, directly or indirectly related to the life cycle of the virus. Here, we analyzed three human genetic polymorphisms belonging to the TMPRSS2 and CCR5 genes in a sample population from Sicily (Italy) to investigate possible correlations with the resistance to viral infection and/or to COVID-19 disease progression as recently described in other human populations. Our results did not show any correlations of the rs35074065, rs12329760, and rs333 polymorphisms with SARS-CoV-2 infection or with COVID-19 disease severity. Further studies on other human genetic polymorphisms should be performed to identify the major human determinants of SARS-CoV-2 viral resistance.

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“…Some of these variants affect the genes involved in innate immunity and inflammation through several pathways. This gene polymorphism has a different geographic distribution that could influence the impact of the infection, hence the different results that are reported by studies conducted in different countries [50,51].…”

Section: Pathogenesis Covid-19 Infection and The Role Of Intrinsic Fa...mentioning

confidence: 99%

The Prevalence and Impact of Coinfection and Superinfection on the Severity and Outcome of COVID-19 Infection: An Updated Literature Review

Omoush

Alzyoud

2022

Pathogens

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Patients with viral illness are at higher risk of secondary infections—whether bacterial, viral, or parasitic—that usually lead to a worse prognosis. In the setting of Corona Virus Disease 2019 (COVID-19), the Severe Acute Respiratory Syndrome Coronavirus-type 2 (SARS-CoV-2) infection may be preceded by a prior microbial infection or has a concurrent or superinfection. Previous reports documented a significantly higher risk of microbial coinfection in SARS-CoV-2-positive patients. Initial results from the United States (U.S.) and Europe found a significantly higher risk of mortality and severe illness among hospitalized patients with SARS-CoV-2 and bacterial coinfection. However, later studies found contradictory results concerning the impact of coinfection on the outcomes of COVID-19. Thus, we conducted the present literature review to provide updated evidence regarding the prevalence of coinfection and superinfection amongst patients with SARS-CoV-2, possible mechanisms underlying the higher risk of coinfection and superinfection in SARS-CoV-2 patients, and the impact of coinfection and superinfection on the outcomes of patients with COVID-19.

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Potential Genes Associated with COVID-19 and Comorbidity

Cited by 31 publications

References 124 publications

COVID-19 Spotlights Connections between Disease and Multiple Lifestyle Factors

COVID-19 Spotlights Connections between Disease and Multiple Lifestyle Factors

Allelic Variations in the Human Genes TMPRSS2 and CCR5, and the Resistance to Viral Infection by SARS-CoV-2

The Prevalence and Impact of Coinfection and Superinfection on the Severity and Outcome of COVID-19 Infection: An Updated Literature Review

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