Potential functions and therapeutic implications of glioma-resident mesenchymal stem cells

Zhang, Qing; Wang, Jialin; Zhang, Junwen; Liu, Fusheng

doi:10.1007/s10565-023-09808-7

Cited by 2 publications

(1 citation statement)

References 109 publications

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“…6,7 Omentum, a specialized type of adipose tissue, has proven to serve as a rich source of adipose-derived mesenchymal stem cells (ADSCs) and fibroblasts, 8 which are important components in the tumor microenvironment (TME) that contribute to tumor progression. 9,10 Cancer-associated fibroblasts (CAFs) are present in different cancers with high heterogeneity, partly due to their varied origins, including mesenchymal stem cells (MSCs), fibroblasts, smooth muscle cells, endothelial cells, and epithelial cells. 11 During cancer progression, the TME undergoes dynamic evolution, resulting in organ-specific metastasis.…”

Section: Introductionmentioning

confidence: 99%

ITGA7 loss drives the differentiation of adipose‐derived mesenchymal stem cells to cancer‐associated fibroblasts

Liu,

Gao,

et al. 2024

Molecular Carcinogenesis

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Cancer‐associated fibroblasts (CAFs) represent a major cellular component of the tumor (pre‐)metastatic niche and play an essential role in omental dissemination of ovarian cancer. The omentum is rich in adipose, and adipose‐derived mesenchymal stem cells (ADSCs) have been identified as a source of CAFs. However, the molecular events driving the phenotype shift of ADSCs remain largely unexplored. In this research, we focus on integrins, transmembrane receptors that have been widely involved in cellular plasticity. We found that integrin α7 (ITGA7) was the only member of the integrin family that positively correlated with both overall survival and progression‐free survival in ovarian cancer through GEPIA2. The immunohistochemistry signal of ITGA7 was apparent in the tumor stroma, and a lower omental ITGA7 level was associated with metastasis. Primary ADSCs were isolated from the omentum of patients with ovarian cancer and identified by cellular morphology, biomarkers, and multilineage differentiation. The conditional medium of ovarian cancer cells induced ITGA7 expression decrease and phenotypic changes in ADSCs. Downregulation of ITGA7 in primary omental ADSCs led to decrease in stemness properties and emerge of characteristic morphology and biomarkers of CAFs. Moreover, the conditioned medium of ADSCs with ITGA7 depletion exhibited enhanced abilities to improve the migration and invasion of ovarian cancer cells in vitro. Overall, these findings indicate that loss of ITGA7 may induce the differentiation of ADSCs to CAFs that contribute to a tumor‐supportive niche.

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Section: Introductionmentioning

confidence: 99%

ITGA7 loss drives the differentiation of adipose‐derived mesenchymal stem cells to cancer‐associated fibroblasts

Liu,

Gao,

et al. 2024

Molecular Carcinogenesis

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Glioma-associated mesenchymal stem cells

Kang,

Wang,

Chen

et al. 2023

Brain

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Recent studies revealed that glioma-associated mesenchymal stem cells play instrumental roles in tumorigenesis and tumor progression and cannot be ignored as a cellular component of the glioma microenvironment. Nevertheless, the origin of these cells and their roles are poorly understood. The only relevant studies have shown that glioma-associated mesenchymal stem cells play a large role in promoting tumor proliferation, invasion and angiogenesis. The following review provides a comprehensive summary of their discovery and definition, origin, differences from other tissue-derived mesenchymal stem cells, spatial distribution, functions, and prognostic and therapeutic opportunities to deepen the understanding of these cells and provide new insight into the treatment of glioma.

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Potential functions and therapeutic implications of glioma-resident mesenchymal stem cells

Cited by 2 publications

References 109 publications

ITGA7 loss drives the differentiation of adipose‐derived mesenchymal stem cells to cancer‐associated fibroblasts

ITGA7 loss drives the differentiation of adipose‐derived mesenchymal stem cells to cancer‐associated fibroblasts

Glioma-associated mesenchymal stem cells

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