Potential functional variants of KIAA genes are associated with breast cancer risk in a case control study

Zhou, Jing; Chen, Congcong; Liu, Sijun; Zhou, Wen; Du, Jiangbo; Jiang, Yue; Dai, Juncheng; Jin, Guangfu; Ma, Hongxia; Hu, Zhibin; Chen, Jiaping; Shen, Hongbing

doi:10.21037/atm-20-6108

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Another gene of interest, PGAM5, a mitochondrial phosphatase, demonstrated elevated expression in various cancers and a potential role in initiating necroptosis [ 44 , 45 , 46 , 47 ]. FADD and KIAA family-related genes were also implicated in tumor progression [ 48 , 49 , 50 ], while SMN1 showed connections to immune function and poor prognosis in related tumors [ 51 , 52 ]. Collectively, these findings suggest that these genes contribute to OSCC development, metastasis, and immune modulation, impacting prognosis adversely.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Necroptosis-Related Genes Signature in Oral Squamous Cell Carcinoma

Huang,

Gu,

et al. 2023

Cancers

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The dual role of necroptosis in inhibiting and promoting tumor development has gradually received much attention because of its essential significance for targeted treatment. Accordingly, this study aims to explore the relationship between necroptosis and oral squamous cell carcinoma (OSCC), and search for novel prognostic factors for OSCC. RNA-seq data and clinical information were downloaded from TCGA and GTEx databases. The prognostic signature of necroptosis-related genes (NRGs) was constructed by univariate Cox regression analysis and the LASSO Cox regression model. Moreover, survival analyses, ROC curves, and nomograms were adopted to further analyze. GO and KEGG analyses and immune infiltration analyses were used for function enrichment and immune feature research in turn. The NRG prognostic signature expression was higher in OSCC tissues than in normal tissues, and the overall survival (OS) rate of the high-expression group was much lower. HPRT1 was proved to be an independent prognostic factor in OSCC. Furthermore, the function enrichment analyses revealed that NRGs were involved in necroptosis, apoptosis, inflammation, and immune reaction. The expression of NRGs was related to immunosuppression in OSCC. Furthermore, the knockdown of HPRT1 could suppress the proliferation and migration of OSCC. In conclusion, the high expression of NRG prognostic signature is associated with poor prognosis in OSCC, and HPRT1 can serve as a novel independent prognostic factor for OSCC.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Necroptosis-Related Genes Signature in Oral Squamous Cell Carcinoma

Huang,

Gu,

et al. 2023

Cancers

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Targeting Hypoxia and HIF1α in Triple-Negative Breast Cancer: New Insights from Gene Expression Profiling and Implications for Therapy

Han,

Li,

Luo

et al. 2024

Biology

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Breast cancer is a complex and multifaceted disease with diverse risk factors, types, and treatment options. Triple-negative breast cancer (TNBC), which lacks the expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2), is the most aggressive subtype. Hypoxia is a common feature of tumors and is associated with poor prognosis. Hypoxia can promote tumor growth, invasion, and metastasis by stimulating the production of growth factors, inducing angiogenesis, and suppressing antitumor immune responses. In this study, we used mRNA-seq technology to systematically investigate the gene expression profile of MDA-MB-231 cells under hypoxia. We found that the hypoxia-inducible factor (HIF) signaling pathway is the primary pathway involved in the cellular response to hypoxia. The genes in which expression levels were upregulated in response to hypoxia were regulated mainly by HIF1α. In addition, hypoxia upregulated various genes, including Nim1k, Rimkla, Cpne6, Tpbgl, Kiaa11755, Pla2g4d, and Ism2, suggesting that it regulates cellular processes beyond angiogenesis, metabolism, and known processes. We also found that HIF1α was hyperactivated in MDA-MB-231 cells under normoxia. A HIF1α inhibitor effectively inhibited the invasion, migration, proliferation, and metabolism of MDA-MB-231 cells. Our findings suggest that hypoxia and the HIF signaling pathway play more complex and multifaceted roles in TNBC than previously thought. These findings have important implications for the development of new therapeutic strategies for TNBC.

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Potential functional variants of KIAA genes are associated with breast cancer risk in a case control study

Cited by 2 publications

References 35 publications

Prognostic Value of Necroptosis-Related Genes Signature in Oral Squamous Cell Carcinoma

Prognostic Value of Necroptosis-Related Genes Signature in Oral Squamous Cell Carcinoma

Targeting Hypoxia and HIF1α in Triple-Negative Breast Cancer: New Insights from Gene Expression Profiling and Implications for Therapy

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