Potential favourable health effects of some dietary uncommon fatty acids

Coudray, Charles; Durand, Erwann; Balas, Laurence; Sultan, Ariane; Casas, François; Feillet‐Coudray, Christine

doi:10.1051/ocl/2021028

Cited by 2 publications

(2 citation statements)

References 80 publications

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“…FAHFA corresponds to a lipid family found in animal tissues and is mainly constituted by two fatty acids and a hydroxyl group representing a large reservoir of neutral lipids released by lipolytic enzymes [ 29 ]. In humans, this type of lipid can be synthesized endogenously but can also be acquired through ingesting animal products, and has recently been considered to be a bioactive lipid with anti-inflammatory and antidiabetic effects [ 30 , 31 ]. However, their presence in rainbow trout muscle has not been reported so far.…”

Section: Resultsmentioning

confidence: 99%

Analysis of Muscle Lipidome in Juvenile Rainbow Trout Fed Rapeseed Oil and Cochayuyo Meal

et al. 2022

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This study aimed to analyze the effects on the lipidome of juvenile Oncorhynchus mykiss muscle fed 90% Brassica napus “rapeseed” oil and different amounts of Durvillaea antarctica “Cochayuyo” meal (1.5, 3 and 6%) as a replacement for cellulose. The analysis allowed for the identification of 329 lipids, mainly represented by phospholipids and fatty esters. The inclusion of Brassica napus oil significantly increased the levels of C18:2 species and fatty esters of hydroxylated fatty acids, which could play a bioactive role in human health. One of the most abundant lipids in all fillets was Phosphatidylcholine 33:6, which, according to the literature, could be considered a biomarker for the identification of Oncorhynchus mykiss. In all experimental diets, the species Phosphatidylethanolamine 15:1-18:24 showed four-fold higher levels than the control; increments of n-3- and n-6-rich phospholipids were also observed. Diets containing Durvillaea antarctica meal did not generate more significant variation in fish muscle phospholipids relative to the muscle of the rapeseed-oil-only group. These lipid species consist of medium- and long-chain fatty acids with different degrees of unsaturation. Still, it appears that the rapeseed oil masks the lipid contribution of the meal, possibly due to the low levels of total lipids in the macroalgae.

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Section: Resultsmentioning

confidence: 99%

Analysis of Muscle Lipidome in Juvenile Rainbow Trout Fed Rapeseed Oil and Cochayuyo Meal

et al. 2022

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“…Putative identifications of those biomarkers revealed that they belonged to the compound classes of phosphatidic acid (PA) and aromatic polyketide derivatives. Fatty acid derivatives and their high bioactive potential for many human diseases can be seen in the literature [ 24 ]. Omega-3 polyunsaturated fatty acids (ω-3 PUFA’s), like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are well studied fatty acids that are obtained from natural resources (vegetables and fish, for example), which reduced fat accumulation and improved metabolic diseases related with obesity (diabetes, cardiac diseases, and cholesterol levels) [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolite Profile Characterization of Cyanobacterial Strains with Bioactivity on Lipid Metabolism Using In Vivo and In Vitro Approaches

Ribeiro,

Jónsdóttir,

Hernandez-Bautista

et al. 2023

Marine Drugs

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Cyanobacteria have demonstrated their therapeutic potential for many human diseases. In this work, cyanobacterial extracts were screened for lipid reducing activity in zebrafish larvae and in fatty-acid-overloaded human hepatocytes, as well as for glucose uptake in human hepatocytes and ucp1 mRNA induction in murine brown adipocytes. A total of 39 cyanobacteria strains were grown and their biomass fractionated, resulting in 117 chemical fractions. Reduction of neutral lipids in zebrafish larvae was observed for 12 fractions and in the human hepatocyte steatosis cell model for five fractions. The induction of ucp1 expression in murine brown adipocytes was observed in six fractions, resulting in a total of 23 bioactive non-toxic fractions. All extracts were analyzed by untargeted UPLC-Q-TOF-MS mass spectrometry followed by multivariate statistical analysis to prioritize bioactive strains. The metabolite profiling led to the identification of two markers with lipid reducing activity in zebrafish larvae. Putative compound identification using mass spectrometry databases identified them as phosphatidic acid and aromatic polyketides derivatives—two compound classes, which were previously associated with effects on metabolic disorders. In summary, we have identified cyanobacterial strains with promising lipid reducing activity, whose bioactive compounds needs to be identified in the future.

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Potential favourable health effects of some dietary uncommon fatty acids

Cited by 2 publications

References 80 publications

Analysis of Muscle Lipidome in Juvenile Rainbow Trout Fed Rapeseed Oil and Cochayuyo Meal

Analysis of Muscle Lipidome in Juvenile Rainbow Trout Fed Rapeseed Oil and Cochayuyo Meal

Metabolite Profile Characterization of Cyanobacterial Strains with Bioactivity on Lipid Metabolism Using In Vivo and In Vitro Approaches

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