Potential factors influencing the development of oral tongue squamous cell carcinoma in young mature patients: Lingual position of the mandibular second molar and narrow tongue space

Abstract

The lingual position of the mandibular second molar and narrow tongue space are associated with oral tongue squamous cell carcinoma (OTSCC) development in young mature patients. The present study aimed to assess the role of the mandibular second molar position and tongue space in young mature patients with OTSCC. The medical records of 21 patients with OTSCC aged <50 years, who had an intact mandibular second molar and had undergone computed tomography (CT) imaging between April 2009 and December 2015 at the Section of Maxillofacial Surgery in Tokyo Medical and Dental University, were retrospectively examined. As controls, 21 sex-matched patients of a similar age to the patients in the OTSCC group, and with a height and weight within 5% of those of the OTSCC group, were collected. The location of the mandibular second molar on the affected side and area of the tongue space were determined using coronal and axial CT images. Mann-Whitney U test analysis revealed that the location of the mandibular second molar and the area of the tongue space differed significantly between young mature patients with OTSCC and the controls. The present study thus revealed that the lingual position of the mandibular second molar and the narrow tongue space may be potential factors influencing OTSCC development in young maturity.

Multicenter retrospective analysis of clinicopathological features and prognosis of oral tongue squamous cell carcinoma in adolescent and young adult patients

“…[12,[26][27][28][29][30][31][32] However, since the duration of the exposure to the aforementioned causes is apparently shorter in AYA patients than in elderly patients, those causes cannot be applied for the development of OTSCC in AYA patients. Kim et al [33] reported that the lingual position of the mandibular second molar and the narrow tongue space in young mature patients are associated with tongue cancer development. Therefore, we believe that AYA patients with OTSCC tend to have specific anatomical physical characteristics.…”

Bone marrow mesenchymal stem cells interact with head and neck squamous cell carcinoma cells to promote cancer progression and drug resistance

“…The majority of OSCC are diagnosed at a late phase, in stages III or IV, which markedly decreases the chances of survival and leads to a significant deterioration in patient quality of life. Despite the currently available therapeutic strategies, which include the excision of malignant tissue in combination with radiotherapy and chemotherapy, the 5‑yr survival rate is still around 50% [6] , [7] , [8] . In addition, a high percentage of patients have a poor response to therapy and high recurrence rates.…”