Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model

Vo, Thuy Thị Bich; Yoo, Yeong‐Min; Choi, Kyung‐Chul; Jeung, Eui‐Bae

doi:10.1016/j.reprotox.2010.01.013

Cited by 209 publications

(148 citation statements)

References 69 publications

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“…In newborns the skin barrier is not fully developed and compounds from personal care products can be transdermally absorbed more than in adults. Many personal care products still contain as additives or ingredients xenobiotics that can act as xenoestrogens, like parabens (especially butyl-and propyl-) used as preservants [67,68] and the UV-filtering agent methyl benzylidene camphor [69]. Products for newborns also may contain extracts from plants containing phytoestrogens such as the phytosterol-rich Aloe vera [70].…”

Section: Xenoestrogen Exposure and Cancer Risk In Newborns And Toddlersmentioning

confidence: 99%

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

Fučić¹,

Mantovani²

2016

Open Biot. J.

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Susceptibility to environmental stressors, same as cancer incidence is both age and gender related. Understanding the complexity of responses to living environment has been impaired due to research based on reductionisms and lack of methods, models and sophisticated softwares which enable analysis of complex pathways which may be disturbed by xenobotics. Impact of estrogen on development, maturation and homeostasis of organism in both genders is now well recognised and environmental investigations are currently making major efforts to understand how xenoestrogens affect organisms at very low doses. Additionally, it is of great interest to learn possible synergistic or antagonistic effects of xenoestrogen mixtures on adult organism and during development. The aim of this paper is to review the findings on the association between cancer risk and the endocrine disrupters which directly or indirectly mimic estrogen action.

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Section: Xenoestrogen Exposure and Cancer Risk In Newborns And Toddlersmentioning

confidence: 99%

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

Fučić¹,

Mantovani²

2016

Open Biot. J.

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show abstract

“…In newborns the skin barrier is not fully developed and compounds from personal care products can be transdermally absorbed more than in adults. Many personal care products still contain as additives or ingredients xenobiotics that can act as xenoestrogens, like parabens (especially butyl-and propyl-) used as preservants [67,68] thus an involvement of xenoestrogens in the pathogenesis might deserve some attention.…”

Section: Xenoestrogen Exposure and Cancer Risk In Newborns And Toddlersmentioning

confidence: 99%

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

Fučić¹,

Mantovani²

2015

TOBIOTJ

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Susceptibility to environmental stressors, same as cancer incidence is both age and gender related. Understanding the complexity of responses to living environment has been impaireddue to research based on reductionisms and lack of methods, models and sophisticated softwares which enable analysis of complex pathways which may be disturbed by xenobotics. Impact of estrogen on development, maturation and homeostasis of organism in both genders is now well recognised and environmental investigations are currently making major efforts to understand how xenoestrogens affect organisms at very low doses.Additionally, it is of great interest to learn possible synergistic or antagonistic effects of xenoestrogen mixtures on adult organism and during development. The aim of this paper is to review the findings on the association between cancer risk and the endocrine disrupters which directly or indirectly mimic estrogen action.

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“…There are many ingredients loading in the cosmetics products; parabens (methyl, ethyl, propyl, and butyl) are one of the important ingredients loaded in most of the cosmetic products, as preservatives due to its excellent antimicrobial property and low toxicity [1]. However, recent study shreds of evidence that parabens may not be as safe as initially thought, and suggest that, they have a potential estrogenic effect on animals and human reproductive system [2][3][4][5]. On the other hand, none of the cosmetic product contains a proper label claim of these ingredients in their cover; hence, the need for quantifying these harmful ingredients in cosmetics has been put forth.…”

Section: Introductionmentioning

confidence: 99%

Central Composite Design to Develop a Robust Reversed-Phase Thin-Layer Chromatography/Densitometry Method for Quantification of Parabens in Cosmetic Preparations

Kavitha

Lakshmi

2017

Asian J Pharm Clin Res

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Objective: The current study was framed with a view to develop a simple, sensitive and a rapid reversed-phase thin-layer chromatography (RP-TLC)/ densitometry method for quantification of parabens (methyl, ethyl, propyl, and butyl) in various cosmetic preparations available in local market. Moreover, robustness testing was planned to be performed applying a central composite design (CCD). Methods:The desired chromatographic separation was achieved on RP-TLC/densitometry plates precoated with Silica gel 60 GF 254 on aluminum sheet, employing methanol:toluene:acetonitrile:glacial acetic acid as mobile phase in the ratio of 3:5:1.8:0.2 v/v/v/v and detection was carried out at 256 nm. Results:The mobile phase used gave an excellent resolution of all the four separated parabens. The method was found linear over a wide range of 6.25-400 ng/spot. The optimized method was validated by measuring various validation parameters. CCD was employed to check the robustness of the method at three-factor levels. The developed and optimized method was used to quantify parabens in 30 different cosmetic products procured from local market. Conclusion:The proposed and developed RP-TLC/densitometry method can be applied for routine analysis of all the parabens in cosmetic products and can also be extended to the analysis in pharmaceuticals and food products.

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Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model

Cited by 209 publications

References 69 publications

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

Central Composite Design to Develop a Robust Reversed-Phase Thin-Layer Chromatography/Densitometry Method for Quantification of Parabens in Cosmetic Preparations

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