Potential Epigenetic Modifications Implicated in Triple- To Quadruple-Negative Breast Cancer Transition: A Review

Muhammad, Aliyu; Forcados, Gilead Ebiegberi; Katsayal, Babangida Sanusi; Bako, Rabiatu Suleiman; Aminu, Suleiman; Sadiq, Idris Zubairu; Abubakar, Murtala Bello; Yusuf, Abdurrahman Pharmacy; Malami, Ibrahim; Faruk, Mohammed; Ibrahim, Sani; Pase, Peter Abur; Ahmed, S. A.; Abubakar, Ibrahim Babangida; Abubakar, Murtala; Yates, Clayton

doi:10.2217/epi-2022-0033

Cited by 8 publications

(5 citation statements)

References 104 publications

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“…Clinically, miRNAs such as miR-155, miR-222, miR-125b, and miR-21 are associated with tumor resistance to the most common systemic treatments, qualifying them as potential predictors of response to breast cancer therapeutics 27 . Our group recently demonstrated 28 that miRNAs like miR-17-5p, miR-432, miR-663a, and miR-1225 are implicated in the TNBCto-QNBC transition, further underscoring their roles in cancer disparities. miRNA expression levels impact the levels of downstream genes or clinically relevant biomarkers.…”

Section: Discussionmentioning

confidence: 94%

MicroRNAs within the Basal-like signature of Quadruple Negative Breast Cancer impact overall survival in African Americans

Angajala

Raymond

Muhammad

et al. 2022

Sci Rep

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We previously found that QNBC tumors are more frequent in African Americans compared to TNBC tumors. To characterize this subtype further, we sought to determine the miRNA–mRNA profile in QNBC patients based on race. Both miRNA and mRNA expression data were analyzed from TCGA and validated using datasets from the METABRIC, TCGA proteomic, and survival analysis by KMPLOT. miRNA–mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-β, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. Thus, QNBC tumors have an altered gene signature implicated in racial disparity and poor survival.

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Section: Discussionmentioning

confidence: 94%

MicroRNAs within the Basal-like signature of Quadruple Negative Breast Cancer impact overall survival in African Americans

Angajala

Raymond

Muhammad

et al. 2022

Sci Rep

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“…Until now, the most predominant idea about the malignant transformation of breast tissue has been attributed to changes in genetic structure, which may be due to epigenetic [46][47][48] or genetic effects per se 49,50 . These changes generate a process that alters the synthesis of proteins, their behavior and therefore the signaling around the tissue, from a biochemical and molecular point of view 51,52 .…”

Section: Discussionmentioning

confidence: 99%

Field Effect Detection by Light Scattering in the Breast Cancer Risk Determination

Pinto

Torrado

Miranda

2023

Preprint

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Breast cancer is one of the most common causes of death in women worldwide; however, early detection could mitigate theassociated number of deaths, where new screening techniques applicable to the entire risk population are the key to achievingthis goal. By identifying the risk population, it is easier to plan cancer prevention programs and contribute to reducing thenumber of deaths from breast cancer; however, despite new promising technologies for early cancer detection, there arefew proposals available to achieve massively applicable techniques to screen the entire breast cancer risk population. Wepresent a proof-of-concept for screening breast cancer using a noninvasive and potentially low-cost technique that detects thecancerization field effect by spectral analysis (FEDSA) using near-infrared backscattered light. To test the concept of FEDSA todetect cancer, we performed FEDSA measurements in 24 women divided into two groups, the first group of 17 normal womenand the second group of seven women with previously detected abnormalities in the breast; we identified significant differencesin the FEDSA spectra of both groups, suggesting the potential of FEDSA as a promising screening technique for the earlydetection of breast cancer.

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“…Epigenetics is an important component that controls the development and variation of single cells, such as DNA methylation, histone modification, and regulation of non-coding RNA [ 25 ]. Epigenetic modification plays an important role in the occurrence and development of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Effect of Kaempferol on the Biological Behavior of Human Colon Cancer via Regulating MMP1, MMP2, and MMP9

Zhang

Fan

Guo

et al. 2022

Journal of Oncology

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Kaempferol is a kind of flavonoid, which has a significant anticancer effect. MMPs were discovered with the function of cleaving the extracellular matrix. We utilized bioinformatics to analyze the association and bonding mode between the traditional Chinese medicine (TCM) monomer composition (i.e., kaempferol) and the target proteins. The purpose of our research was to verify the effect of kaempferol on the biological behavior of human colon cancer cells HCT116 and HT29 and the expression of matrix metalloproteinase (MMP) 1, 2, and 9 genes. We detected the changes in the biological behavior of colon cancer cells treated with kaempferol by CCK-8, wound healing assay, transwell migration/invasion assay, and flow cytometry. Meanwhile， we detected the expression difference of the target gene by qRT-PCR and western blot. Compared with the two control groups, the cell viability of the kaempferol group decreased, the rate of cell migration and the number of transmembrane cells in the kaempferol group decreased significantly, and the early apoptosis rate increased, the number of cells in the G1 phase increased and in the S phase decreased. The results of qRT-PCR and western blot showed that the expression of target genes MMP1, 2, and 9 in the kaempferol group was lower than that in the two control groups. Kaempferol can significantly inhibit the proliferation, invasion, and migration ability of colon cancer cells; induce their apoptosis; and block the cell cycle. Meanwhile, the expression of MMP1, 2, and 9 genes was downregulated, which verified the results of bioinformatic analysis.

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Potential Epigenetic Modifications Implicated in Triple- To Quadruple-Negative Breast Cancer Transition: A Review

Cited by 8 publications

References 104 publications

MicroRNAs within the Basal-like signature of Quadruple Negative Breast Cancer impact overall survival in African Americans

MicroRNAs within the Basal-like signature of Quadruple Negative Breast Cancer impact overall survival in African Americans

Field Effect Detection by Light Scattering in the Breast Cancer Risk Determination

Effect of Kaempferol on the Biological Behavior of Human Colon Cancer via Regulating MMP1, MMP2, and MMP9

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