Potential employment of non-silica-based stationary phases in pharmaceutical analysis

Žižkovský, Václav; Kučera, Radim; Klimeš, Jiřı́

doi:10.1016/j.jpba.2007.04.027

Cited by 12 publications

(12 citation statements)

References 29 publications

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“…m- ZrO 2 is stable at low temperature and transforms into t- ZrO 2 or c-ZrO 2 at 1170 °C and 2370 °C, respectively [73,74]. Interesting optical properties [75], combined with thermal and chemical stability, make zirconia useful within areas such as: oral transplantology [76,77,78], solid oxide fuel cells [79], hydrogen production [80,81], biomass conversion [82], catalytic supports [83], chromatographic purification/separation of pharmaceuticals [84]. …”

Section: Monolithic Oxidesmentioning

confidence: 99%

Sol-Gel Synthesis of Non-Silica Monolithic Materials

2010

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Monolithic materials have become very popular because of various applications, especially within chromatography and catalysis. Large surface areas and multimodal porosities are great advantages for these applications. New sol-gel preparation methods utilizing phase separation or nanocasting have opened the possibility for preparing materials of other oxides than silica. In this review, we present different synthesis methods for inorganic, non-silica monolithic materials. Some examples of application of the materials are also included.

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Section: Monolithic Oxidesmentioning

confidence: 99%

Sol-Gel Synthesis of Non-Silica Monolithic Materials

2010

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“…Regarding our experience with metal oxide phases [19][20][21][22] phosphate as the Lewis base was chosen for purposes of this comparative study. Acetate was avoided due to problems associated with Lewis acidic analytes on the reference Zr-PBD column, see section 3.4.…”

Section: Resultsmentioning

confidence: 99%

“…Based on the previous experience with separation of ondansetron and five related compounds (impurities C -G) on Zr-PBD [19], the model method transfer to Zr-MS column was performed (Fig. 5) and aimed at the enhancement of the sensitivity using mass detection.…”

Section: Separation Of Ondansetronmentioning

confidence: 99%

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The Retention Behavior of Acidic, Basic and Neutral Pharmaceuticals on the Deactivated Polybutadiene Zirconia Phase

Kalafut¹,

Kučera

Klimeš³

2012

CAC

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Reversed zirconia-based stationary phases belong among interesting alternatives of widely used RP silica phases. Zirconia displays specific surface properties, which are responsible for a unique retention mechanism. Furthemore, it is necessary especially for acidic analytes to add a strong Lewis base to the mobile phase mainly to improve the separation efficiency. However, commonly recommended strong Lewis base buffers are not volatile and therefore are incompatible with a mass spectrometric detection.A novel RP zirconia-based stationary phase with deactivated Lewis acid sites of zirconia was introduced to enable the use of volatile additives (acetate, formate) despite their low Lewis basicity. It is reported on the influence of surface deactivation on chromatographic behavior of acidic, basic and neutral analytes in this paper. The influence of variables such as pH levels, Lewis base type, its concentration and temperature were studied. The results were compared with the undeactivated stationary phase. In general, around 2.5-fold stronger retention of compounds was observed on the deactivated phase. Moreover, some variances in retention and selectivity were observed for both acidic and basic analytes when using different Lewis bases. For these reasons the properties of deactivated and unmodified phases under the same conditions were partly diverse and consequently the selectivity was similar but not identical.

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“…Alguns óxidos metálicos podem ser utilizados como suporte para CLAE-FR. Dentre eles se destacam o uso de alumina, titânia e zircônia e, mais recentemente, os óxidos de cério e tório, devido à duas características: a estabilidade química e a excelente estabilidade térmica desses materiais [6,[26][27][28][29].…”

Section: Suportes De óXidos Metálicosunclassified

Desenvolvimento de fases estacionárias C18 termicamente imobilizadas sobre sílica e sílicas metalizadas e suas caracterizações químicas, físicas e cromatográficas utilizando a cromatografia líquida de alta eficiência (CLAE) e a cromatografia com fluido supercrítico (CFS)

Silva¹

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Aos meus pais, Maria Elaine e Carlos (in memorian), a minha avó D. Maria, por sempre acreditarem em mim e serem a base para que eu chegasse até aqui, a minha irmã Natacha, minha sobrinha Louise e a todos aqueles que sempre me incentivaram, em sinal de gratidão e amor, dedico esta tese. viii ix "Above all, don't fear difficult moments. The best comes from them." (Rita Levi-Montalcini) "Fais de ta vie un rêve, et d'un rêve, une réalité." (Antoine de Saint-Exupéry) x xi AGRADECIMENTOS À Professora Carol Hollingworth Collins, pela oportunidade e os ensinamentos, pelo exemplo de orientação e pela amizade, confiança e liberdade para conduzir meu projeto. À Dra Caroline West e ao Dr. Eric Lesellier pelo aceite de orientação, vontade de ensinar e por todos os conhecimentos adquiridos durante a minha participação no Programa de Doutorado Sanduíche no Exterior (PDSE) no Institut de Chimie Organique et Analytique da Université d´Orléans. À Professora Isabel Cristina Sales Fontes Jardim, pelos conhecimentos transmitidos, pela companhia agradável e exemplo profissional.

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Potential employment of non-silica-based stationary phases in pharmaceutical analysis

Cited by 12 publications

References 29 publications

Sol-Gel Synthesis of Non-Silica Monolithic Materials

Sol-Gel Synthesis of Non-Silica Monolithic Materials

The Retention Behavior of Acidic, Basic and Neutral Pharmaceuticals on the Deactivated Polybutadiene Zirconia Phase

Desenvolvimento de fases estacionárias C18 termicamente imobilizadas sobre sílica e sílicas metalizadas e suas caracterizações químicas, físicas e cromatográficas utilizando a cromatografia líquida de alta eficiência (CLAE) e a cromatografia com fluido supercrítico (CFS)

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