Potential emergence of terbinafine resistance by squalene epoxidase gene mutations: An 18‐month cohort study of onychomycosis patients in the United States
Aditya K. Gupta,
Tong Wang,
Shruthi Polla Ravi
et al.
Abstract:BackgroundThere is a concerning rise in antifungal‐resistant dermatophytosis globally, with resistance to terbinafine conferred by point mutations in the squalene epoxidase (SQLE) gene.ObjectivesReport changes in the prevalence and profile of SQLE mutations in onychomycosis patients in the United States.MethodsA longitudinal cohort study of toenail samples was collected from suspected onychomycosis patients over an 18‐month period from 2022 to 2023. Samples were submitted from across the United States and subj… Show more
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