Potential Efficacy of Nutrient Supplements for Treatment or Prevention of COVID-19

Bogan-Brown, Katrina; Nkrumah‐Elie, Yasmeen; Ishtiaq, Yusrah; Redpath, Philip; Shao, Andrew

doi:10.1080/19390211.2021.1881686

Cited by 17 publications

(16 citation statements)

References 202 publications

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“…Zinc is as an essential micronutrient that is required to mount an effective antiviral response [118,119]. It is also critical in generating both innate and acquired (humoral) antiviral responses.…”

Section: Artemisia and Zincmentioning

confidence: 99%

“…The flavonoids and other phenolic compounds present in A. annua also act as potent zinc ionophores [120,121]. Quercetin, one of the most abundant polyphenolics found in A. annua, plays a relevant beneficial role [77], in part, based on its antioxidant actions, which are partially derived from its interaction with iron, copper and zinc [118][119][120][121].…”

Section: Artemisia and Zincmentioning

confidence: 99%

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RETRACTED: Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?

Agrawal¹,

Agrawal²,

Blunden

2022

Molecules

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As the world desperately searches for ways to treat the coronavirus disease 2019 (COVID-19) pandemic, a growing number of people are turning to herbal remedies. The Artemisia species, such as A. annua and A. afra, in particular, exhibit positive effects against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and COVID-19 related symptoms. A. annua is a source of artemisinin, which is active against malaria, and also exhibits potential for other diseases. This has increased interest in artemisinin’s potential for drug repurposing. Artemisinin-based combination therapies, so-called ACTs, have already been recognized as first-line treatments against malaria. Artemisia extract, as well as ACTs, have demonstrated inhibition of SARS-CoV-2. Artemisinin and its derivatives have also shown anti-inflammatory effects, including inhibition of interleukin-6 (IL-6) that plays a key role in the development of severe COVID-19. There is now sufficient evidence in the literature to suggest the effectiveness of Artemisia, its constituents and/or artemisinin derivatives, to fight against the SARS-CoV-2 infection by inhibiting its invasion, and replication, as well as reducing oxidative stress and inflammation, and mitigating lung damage.

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Section: Artemisia and Zincmentioning

confidence: 99%

Section: Artemisia and Zincmentioning

confidence: 99%

RETRACTED: Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?

Agrawal¹,

Agrawal²,

Blunden

2022

Molecules

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“…Although further studies are needed to conclusively determine the impact of SARS-CoV-2-mediated NAD+ depletion in PACS pathogenesis, preclinical and clinical data has suggested that supplementation with NAD+ or its analogs may accelerate PACS recovery. 55 - 59 Moreover, there is one ongoing pilot study with NAD+ investigating its effect on reducing fatigue in PACS. 60 Despite the evidence supporting NAD+ supplementation as potential PACS therapy, considerably more information about the safety, efficacy and potential long-term sequel of IV NAD+ administration is required to claim a therapeutic effect in PACS patients.…”

Section: Rationale For Nad+ Intravenous Administration Therapy For Pa...mentioning

confidence: 99%

Rationale for Nicotinamide Adenine Dinucleotide (NAD+) Metabolome Disruption as a Pathogenic Mechanism of Post-Acute COVID-19 Syndrome

Block

Kuo

2022

Clin Med�Insights�Pathol

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Many acute COVID-19 convalescents experience a persistent sequelae of infection, called post-acute COVID-19 syndrome (PACS). With incidence ranging between 31% and 69%, PACS is becoming increasingly acknowledged as a new disease state in the context of SARS-CoV-2 infection. As SARS-CoV-2 infection can affect several organ systems to varying degrees and durations, the cellular and molecular abnormalities contributing to PACS pathogenesis remain unclear. Despite our limited understanding of how SARS-CoV-2 infection promotes this persistent disease state, mitochondrial dysfunction has been increasingly recognized as a contributing factor to acute SARS-CoV-2 infection and, more recently, to PACS pathogenesis. The biological mechanisms contributing to this phenomena have not been well established in previous literature; however, in this review, we summarize the evidence that NAD+ metabolome disruption and subsequent mitochondrial dysfunction following SARS-CoV-2 genome integration may contribute to PACS biological pathogenesis. We also briefly examine the coordinated and complex relationship between increased oxidative stress, inflammation, and mitochondrial dysfunction and speculate as to how SARS-CoV-2-mediated NAD+ depletion may be causing these abnormalities in PACS. As such, we present evidence supporting the therapeutic potential of intravenous administration of NAD+ as a novel treatment intervention for PACS symptom management.

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“…As natural products and herbal medicines have a promising contribution to drug discovery, these are used to prevent COVID-19 infection ( Bogan-Brown et al., 2021 ). Plants, fungus, and marine sources of natural products are already used to develop drug discovery for several diseases.…”

Section: Introductionmentioning

confidence: 99%

In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective

Rahman

Islam

Akash

et al. 2022

Front. Cell. Infect. Microbiol.

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a substantial number of deaths around the world, making it a serious and pressing public health hazard. Phytochemicals could thus provide a rich source of potent and safer anti-SARS-CoV-2 drugs. The absence of approved treatments or vaccinations continues to be an issue, forcing the creation of new medicines. Computer-aided drug design has helped to speed up the drug research and development process by decreasing costs and time. Natural compounds like terpenoids, alkaloids, polyphenols, and flavonoid derivatives have a perfect impact against viral replication and facilitate future studies in novel drug discovery. This would be more effective if collaboration took place between governments, researchers, clinicians, and traditional medicine practitioners’ safe and effective therapeutic research. Through a computational approach, this study aims to contribute to the development of effective treatment methods by examining the mechanisms relating to the binding and subsequent inhibition of SARS-CoV-2 ribonucleic acid (RNA)-dependent RNA polymerase (RdRp). The in silico method has also been employed to determine the most effective drug among the mentioned compound and their aquatic, nonaquatic, and pharmacokinetics’ data have been analyzed. The highest binding energy has been reported -11.4 kcal/mol against SARS-CoV-2 main protease (7MBG) in L05. Besides, all the ligands are non-carcinogenic, excluding L04, and have good water solubility and no AMES toxicity. The discovery of preclinical drug candidate molecules and the structural elucidation of pharmacological therapeutic targets have expedited both structure-based and ligand-based drug design. This review article will assist physicians and researchers in realizing the enormous potential of computer-aided drug design in the design and discovery of therapeutic molecules, and hence in the treatment of deadly diseases.

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Potential Efficacy of Nutrient Supplements for Treatment or Prevention of COVID-19

Cited by 17 publications

References 202 publications

RETRACTED: Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?

RETRACTED: Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?

Rationale for Nicotinamide Adenine Dinucleotide (NAD+) Metabolome Disruption as a Pathogenic Mechanism of Post-Acute COVID-19 Syndrome

In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective

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