Potential effects of the most prescribed drugs on the microbiota-gut-brain-axis: A review

Garg, Kirti; Mohajeri, M. Hasan

doi:10.1016/j.brainresbull.2024.110883

Cited by 5 publications

(2 citation statements)

References 106 publications

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“…It is anticipated that as our knowledge of the relationship between GM, GBA and the role of SCFAs in MDD expands, more therapeutic interventions by manipulating the GM would become available [229][230][231][232].…”

Section: Microbiota-neurotrophic Factors-neuroinflammationmentioning

confidence: 99%

Role of Glial Cells in Depression and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Preprint

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Major depressive disorder (MDD) and substance use disorder (SUD) are of immense medical and social concerns. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, only relatively recently the role of glia in these disorders have attracted attention. Detail understanding of the glial function in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, specific contribution of the neurotrophic factors, neuroinflammation and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes and synantocytes) on phenotypic manifestation of MDD or SUD are emphasized. In addition, potential use of this knowledge in developing novel therapeutics is touched upon.

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Section: Microbiota-neurotrophic Factors-neuroinflammationmentioning

confidence: 99%

Role of Glial Cells in Depression and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…It is anticipated that as our knowledge of the relationship between GM, GBA, and the role of SCFAs in mood disorders expands, more therapeutic interventions by manipulating GM will become available [ 267 , 268 , 269 ].…”

Section: Microbiota–neurotrophic Factors–neuroinflammationmentioning

confidence: 99%

Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Brain Sciences

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Mood disorders and substance use disorder (SUD) are of immense medical and social concern. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, it is only relatively recently that the role of glia in these disorders has attracted attention. Detailed understanding of the glial functions in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, the specific contributions of neurotrophic factors, neuroinflammation, and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes, and synantocytes) on phenotypic manifestation of mood disorders or SUD are emphasized. In addition, use of this knowledge in the potential development of novel therapeutics is touched upon.

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Long-Term Implicit Epigenetic Stress Information in the Enteric Nervous System and its Contribution to Developing and Perpetuating IBS

Noemi,

Bob,

Bókkon

2024

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Psychiatric and mood disorders may play an important role in the development and persis- tence of irritable bowel syndrome (IBS). Previously, we hypothesized that stress-induced implicit memories may persist throughout life via epigenetic processes in the enteric nervous system (ENS), independent of the central nervous system (CNS). These epigenetic memories in the ENS may con- tribute to developing and perpetuating IBS. Here, we further elaborate on our earlier hypothesis. That is, during pregnancy, maternal prenatal stresses perturb the HPA axis and increase circulating cortisol levels, which can affect the maternal gut microbiota. Maternal cortisol can cross the placental barrier and increase cortisol-circulating levels in the fetus. This leads to dysregulation of the HPA axis, affect- ing the gut microbiota, microbial metabolites, and intestinal permeability in the fetus. Microbial me- tabolites, such as short-chain fatty acids (which also regulate the development of fetal ENS), can mod- ulate a range of diseases by inducing epigenetic changes. These mentioned processes suggest that stress-related, implicit, long-term epigenetic memories may be programmed into the fetal ENS during pregnancy. Subsequently, this implicit epigenetic stress information from the fetal ENS could be con- veyed to the CNS through the bidirectional microbiota-gut-brain axis (MGBA), leading to perturbed functional connectivity among various brain networks and the dysregulation of affective and pain pro-

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Potential effects of the most prescribed drugs on the microbiota-gut-brain-axis: A review

Cited by 5 publications

References 106 publications

Role of Glial Cells in Depression and Drug Addiction

Role of Glial Cells in Depression and Drug Addiction

Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

Long-Term Implicit Epigenetic Stress Information in the Enteric Nervous System and its Contribution to Developing and Perpetuating IBS

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