Potential Effects of Sweet Potato (Ipomoea batatas) in Hyperglycemia and Dyslipidemia—A Systematic Review in Diabetic Retinopathy Context

Naomi, Ruth; Bahari, Hasnah; Yazid, Muhammad Dain; Othman, Fezah; Zakaria, Zainul Amiruddin; Hussain, Mohd Khairi

doi:10.3390/ijms221910816

Cited by 17 publications

(18 citation statements)

References 76 publications

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“…The article search was limited to the past five years. Boolean operator guidelines were followed to select and perform the keywords search [ 13 ]. These are as described as: (1) BPA OR environmental chemical AND fat OR LDL OR obese AND transgenerational effects or phenocopy (2) Endocrine disruptors OR chemical AND lipodystrophy AND phenocopy (3) Lipid profile OR weight changes AND cardiovascular effect (4) BPA AND neuroimmune OR gene signaling.…”

Section: Methodsmentioning

confidence: 99%

Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study

Naomi

Yazid

Bahari

et al. 2022

IJMS

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BPA is one of the most common endocrine disruptors that is widely being manufactured daily nationwide. Although scientific evidence supports claims of negative effects of BPA on humans, there is also evidence suggesting that a low level of BPA is safe. However, numerous in vivo trials contraindicate with this claim and there is a high possibility of BPA exposure could lead to obesity. It has been speculated that this does not stop with the exposed subjects only, but may also cause transgenerational effects. Direct disruption of endocrine regulation, neuroimmune and signaling pathways, as well as gut microbiata, has been identified to be interrupted by BPA exposure, leading to overweight or obesity. In these instances, cardiovascular complications are one of the primary notable clinical signs. In regard to this claim, this review paper discusses the role of BPA on obesity in the perspective of endocrine disruptions and possible cardiovascular complications that may arise due to BPA. Thus, the aim of this review is to outline the changes in gut microbiota and neuroimmune or signaling mechanisms involved in obesity in relation to BPA. To identify potentially relevant articles, a depth search was done on the databases Nature, PubMed, Wiley Online Library, and Medline & Ovid from the past 5 years. According to Boolean operator guideline, selected keywords such as (1) BPA OR environmental chemical AND fat OR LDL OR obese AND transgenerational effects or phenocopy (2) Endocrine disruptors OR chemical AND lipodystrophy AND phenocopy (3) Lipid profile OR weight changes AND cardiovascular effect (4) BPA AND neuroimmune OR gene signaling, were used as search terms. Upon screening, 11 articles were finalized to be further reviewed and data extraction tables containing information on (1) the type of animal model (2) duration and dosage of BPA exposure (3) changes in the lipid profile or weight (4) genes, signaling mechanism, or any neuroimmune signal involved, and (5) transgenerational effects were created. In toto, the study indicates there are high chances of BPA exposure affecting lipid profile and gene associated with lipolysis, leading to obesity. Therefore, this scoping review recapitulates the possible effects of BPA that may lead to obesity with the evidence of current in vivo trials. The biomarkers, safety concerns, recommended dosage, and the impact of COVID-19 on BPA are also briefly described.

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Section: Methodsmentioning

confidence: 99%

Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study

Naomi

Yazid

Bahari

et al. 2022

IJMS

Self Cite

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“…Although full evidence from clinical trials is still lacking, and the long-term effects have not been studied yet, sweet potato has proved effective in treating hyperglycemia, as concluded in a recent systematic review based on in vitro and in vivo studies [ 88 ]. Cardiovascular disorders are one of the most important causes of mortality in type 2 diabetes mellitus, and atherosclerosis is the major cardiovascular complication related to diabetes [ 89 ].…”

Section: Beneficial Health Effects Of Sweet Potatoesmentioning

confidence: 99%

Sweet Potato Is Not Simply an Abundant Food Crop: A Comprehensive Review of Its Phytochemical Constituents, Biological Activities, and the Effects of Processing

et al. 2022

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Nowadays, sweet potato (Ipomoea batata L.; Lam.) is considered a very interesting nutritive food because it is rich in complex carbohydrates, but as a tubercle, contains high amounts of health-promoting secondary metabolites. The aim of this review is to summarize the most recently published information on this root vegetable, focusing on its bioactive phytochemical constituents, potential effects on health, and the impact of processing technologies. Sweet potato is considered an excellent source of dietary carotenoids, and polysaccharides, whose health benefits include antioxidant, anti-inflammatory and hepatoprotective activity, cardiovascular protection, anticancer properties and improvement in neurological and memory capacity, metabolic disorders, and intestinal barrier function. Moreover, the purple sweet potato, due to its high anthocyanin content, represents a unique food option for consumers, as well as a potential source of functional ingredients for healthy food products. In this context, the effects of commercial processing and domestic cooking techniques on sweet potato bioactive compounds require further study to understand how to minimize their loss.

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“…Motivating factors for the adoption of OFSP include: its pleasant taste and pro t from the sale of its roots and vine (Chah et al, 2020;Naomi et al, 2021). Sustainability strategies for scaling up programs should be part of the planning stage.…”

Section: Scaling Up the Value Chain And Adoption Of Orange-fleshed Sw...mentioning

confidence: 99%

“…Complications of the retina; oxidative damage and neovascularization may result (Peng et al, 2019). I. batatas leaves are more effective in treating hyperglycemia than diabinese-a commonly used diabetes drug (Naomi et al, 2021). I. batatas leaves exhibits anti-hyperglycemic effects through the p38 MAP kinase signaling pathway.…”

Section: Health Bene Ts Of Sweet Potatoesmentioning

confidence: 99%

Harnessing the potentials of sweet potatoes for improved food security in developing countries.

Ojimelukwe

Ukom²

2022

Preprint

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The sweet potato (Ipomea batatas L Lam) is a famine crop with great potentials to supply energy and curb hidden hunger in developing countries. It is the only major root crop (often used as vegetable) with four nutrients that exceed 10% of the recommended daily amount (vitamin A/beta carotene; vitamin C; Fiber and potassium) Commendable research efforts have been dedicated to developing improved varieties of sweet potatoes for pest resistance; yield; stress tolerance; dry matter content; carotenoids (xanthophyll and pro-vitamin A) and mineral content. This paper presents an update on the research status on sweet potatoes and highlights areas for further research for the sustainable use of this cheap source of bioenergy and nutrients as a food security crop. Bio-fortification rather than transgenic research methods has been found to be more suitable for the incorporation of novel nutrients into the crop. Factors that affect the nutrient density and yield of sweet potatoes include: soil nutrient management practices, vine pruning and planting distances. Although they have seeds, sweet potatoes are better propagated with vine cuttings. The level of adoption of orange fleshed sweet potatoes is still low and the problems of seasonality, high costs of good quality planting materials, diversification of value added products and complexity of the production technique for the rural farmer need to be addressed. This crop requires improved research efforts for sustainable food security in developing countries.

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Potential Effects of Sweet Potato (Ipomoea batatas) in Hyperglycemia and Dyslipidemia—A Systematic Review in Diabetic Retinopathy Context

Cited by 17 publications

References 76 publications

Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study

Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study

Sweet Potato Is Not Simply an Abundant Food Crop: A Comprehensive Review of Its Phytochemical Constituents, Biological Activities, and the Effects of Processing

Harnessing the potentials of sweet potatoes for improved food security in developing countries.

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