Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy

Turrini, Eleonora; Ferruzzi, Lorenzo; Fimognari, Carmela

doi:10.1155/2015/938475

Cited by 142 publications

(113 citation statements)

References 151 publications

(197 reference statements)

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“…23 Currently, interest in polyphenols has been raised due to their reported chemo preventive and/or chemotherapeutic potential. 24 In light of the above reports it is to suggest that the profound cytotoxic effect of C. fimbriata ethanolic leaf extract in human colon cells could be due presence of pregnane glycosides. The cytotoxic potential of C. fimbriata could be due to an induction of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells

Ashwini¹,

Ezhilarasan²,

Anitha³

2017

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Aim: The present study was designed to examine the cytotoxic effects of ethanolic leaf extract of Caralluma fimbriata in the COLO 320 cell line. Materials and Method: The anti-proliferative effects were evaluated using the MTT assay. The COLO 320 cells were treated with different concentrations of the leaf extract of Caralluma (100 -300 µg/ml) for 24 h. The cell viability and IC 50 was calculated from the cytotoxicity. The morphology of the Caralluma treated cells, control, and positive control were observed under reverse phase inverted microscope. Result: The C. fimbriata ethanolic leaf extract showed dose dependant increase in cytotoxicity in COLO 320 human colon cancer cells. The maximum cytotoxic effect was noticed with maximum dose used in this study i.e., 300 µg with an IC 50 value of 233.87 µg. Conclusion: The present study shows that the ethanolic leaf extract of Caralluma fimbriata is capable of reducing cell proliferation by inducing cytotoxicity of COLO 320 cells.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells

Ashwini¹,

Ezhilarasan²,

Anitha³

2017

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“…The multistage nature of the carcinogenesis process, the presence of precursor lesions at the intermediate stages between normal and malignant cells, the slow growth of tumors and, the long latency, generally for decades before the diagnosis is established indicate that the carcinogenic process could be blocked or delayed and that the development of invasive cancers could be prevented [12].…”

Section: Cancer Development Process and Preventionmentioning

confidence: 99%

Health Benefits of Phenolic Compounds Against Cancers

Basli¹,

Belkacem²,

Amrani³

2017

Phenolic Compounds - Biological Activity

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Phenolic compounds are the biggest group of phytochemicals, and many of them have been found in plant-based foods. Polyphenol-rich diets have been linked to many health beneits including cancer. The potential anti-carcinogenic mechanisms of action that have been so far identiied for phenolic compounds, as well as the feasibility reports occurred in vivo. In general terms, under the oxidative stress, polyphenols could act in those cellular mechanisms by participating in the modulation of the redox status and on multiple key elements in intracellular signal transduction pathways related to cell proliferation, diferentiation, apoptosis, inlammation, angiogenesis and metastasis. A protective role of polyphenols against carcinogenesis is supported by many studies carried out on animal models and diferent mechanisms of action have been proposed to explain such protective efects. Studies performed in animals have demonstrated that phenolic components can prevent and/or slow down the initiation-progression of diferent types of cancers. They act through the regulation of cell signal transduction and gene expression and exhibit either up or down regulation of genes controlling tumor development.

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“…17,18 In addition, PE has been found to induce chemoprevention of liver cancer through antiproliferative, antioxidant and proapoptotic mechanisms. 19 However, although many natural products have been confirmed to have a strong therapeutic efficacy, their low bioavailability and poor solubility have seriously restricted their usage. 11 Nanotechnology is considered as one of the most advanced disciplines that has proved successful yields and mechanisms in defeating cancer; 20 its approaches are employed to cancer therapeutic agents in order to reduce toxicity, improve stability and bioavailabil ity and endorse selective tumor uptake.…”

Section: Introductionmentioning

confidence: 99%

Pomegranate extract-loaded solid lipid nanoparticles: design, optimization, and in vitro cytotoxicity study

Badawi¹,

Teaima²,

El-Say³

et al. 2018

IJN

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Background Pomegranate extract (PE) is a natural product with potent antioxidant and anticancer activity because of its polyphenols content. The main purpose of this study was to maximize the PE chemotherapeutic efficacy by loading it in an optimized solid lipid nanoparticles (SLNs) formula. Materials and methods The influence of independent variables, which were lipid concentration (X 1 ), surfactant concentration (X 2 ) and cosurfactant concentration (X 3 ), on dependent ones, which were particle size (Y 1 ), polydispersity index (Y 2 ), zeta potential (Y 3 ), entrapment efficiency (Y 4 ) and cumulative % drug release (Y 5 ), were studied and optimized using the Box–Behnken design. Fifteen formulations of PE-SLNs were prepared using hot homogenization followed by ultra-sonication technique. Response surface plots, Pareto charts and mathematical equations were produced to study the impact of independent variables on the dependent quality parameters. The anti-proliferative activity of the optimized formula was then evaluated in three different cancer cell lines, namely, MCF-7, PC-3 and HepG-2, in addition to one normal cell line, HFB-4. Results The results demonstrated that the particle sizes ranged from 407.5 to 651.9 nm and the entrapment efficiencies ranged from 56.02 to 65.23%. Interestingly, the 50% inhibitory concentration of the optimized formula had more than a 40-fold improved effect on the cell growth inhibition in comparison with its free counterpart. Furthermore, it was more selective against cancer cells than normal cells particularly in MCF-7 breast cancer cells. Conclusion These data proved that nanoencapsulation of PE enhanced its anticancer efficacy. Therefore, our results suggested that a PE-loaded SLNs optimized-formula could be a promising chemo therapeutic agent.

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Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy

Cited by 142 publications

References 151 publications

Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells

Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells

Health Benefits of Phenolic Compounds Against Cancers

Pomegranate extract-loaded solid lipid nanoparticles: design, optimization, and in vitro cytotoxicity study

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