Abstract:Bone tissue undergoes constant remodeling by reducing the accumulation of bone damage and retaining the mechanical strength of bones to sustain both structural integrity and bone density. There are two main specialized cells involved in the bone-remodeling process, osteoblasts (OBs) and osteoclasts (OCs), which are responsible for new bone formation and aged bone resorption, respectively. The proper balancing act between bone resorption by OCs and bone deposition by OBs is essential for the active and dynamic … Show more
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