Potential Effects of Human Papillomavirus Type Substitution, Superinfection Exclusion and Latency on the Efficacy of the Current L1 Prophylactic Vaccines

Hampson, Ian N.; Oliver, Anthony W.; Hampson, Lynne

doi:10.3390/v13010022

Cited by 12 publications

(11 citation statements)

References 79 publications

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“…There are a few high-risk types such as types 16 and 18, which may produce cervical cell abnormalities, and these types are precursors to oral and genital carcinomas .The risk of human papillomavirus related cancers remains high in individuals unvaccinated against HPV. Human Papillomavirus vaccination is an effective approach for primary prevention of cervical cancer and presents an opportunity to reduce the burden from cervical cancer in a number of countries (Hampson, et al, 2021).…”

Section: Jnsbumentioning

confidence: 99%

Effect of the Educational Package based on Health Belief Model on Nursing Students’ Knowledge and Attitude Regarding Human Papillomavirus and Cervical Cancer

Mahmoud

Aboud

hakam

et al. 2021

Journal of Nursing Science Benha University

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Background: Cervical cancer is a significant health problem worldwide. It is the second most common cancer worldwide in women. Human papillomavirus types are the main cause in activating the growth of cervical cancer. This study aimed to evaluate the effect of the educational package based on health belief model on nursing students' knowledge and attitude regarding human papilloma virus and cervical cancer. Design: A quasi-experimental design (pre and posttest) was used for this study. Setting: The study was conducted in faculty of nursing at Benha University. Sample: a purposive sample included (195) female nursing students. Tools of data collection: Three main tools were used, I: A structured self-administered questionnaire which included 3 parts (1) general characteristics of student nurses,(2) medical history (3) knowledge of student nurses regarding human papilloma virus and cervical cancer , II: Modified Likert scale was developed to assess the nursing students' attitudes regarding human papilloma virus and cervical cancer and III: Health Belief Model Scale was adopted to assess the nursing students' beliefs and behaviors regarding human papilloma virus and cervical cancer. Results: There was a high statistically significant improvement among female nursing students regarding their level of knowledge, attitude and Health Belief Model about human papilloma virus and cervical cancer immediate and 4weeks post-intervention compared to pre-intervention with (P<0.001). Conclusion: Application of the educational package based on health belief model have a positive effect on improving nursing students' knowledge and attitude regarding human papilloma virus and cervical cancer. Recommendations: Application of health belief model for all university students as a healthy preventive behavior towards human papilloma virus and cervical cancer is recommended.

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Section: Jnsbumentioning

confidence: 99%

Effect of the Educational Package based on Health Belief Model on Nursing Students’ Knowledge and Attitude Regarding Human Papillomavirus and Cervical Cancer

Mahmoud

Aboud

hakam

et al. 2021

Journal of Nursing Science Benha University

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“…They are associated with an increased risk of developing vulvar, anal, vaginal, penile, oropharyngeal cancer, while genotypes classified as low risk, i.e. 6 and 11, correlate with the development of genital warts [1,13,14].High-risk subtypes are more common in developing countries than in the US and Europe, but when it comes to oncogenic virus types, other than HPV 16 and HPV 18 are more common there [1].…”

Section: Introductionmentioning

confidence: 99%

HPV virus as the main cause of cervical cancer, vaccination - literature review

Paluch¹,

Tomkiewicz²,

Olko³

et al. 2023

J Educ Health Sport

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HPV infection is one of the most common viral infection of the female and male reproductive tract worldwide. Most of the human papillomavirus infections cause no symptoms and go away on their own. Some infections develop into persistent infection, which can lead to the development of cancer of the cervix, anogenital, oral cavity and pharynx.In this paper, we focused on cervical cancer, which is the second most common cancer in the world among women. More than 300,000 women died from this cancer in 2020. The invention and introduction of prophylactic HPV vaccines has played a significant role in reducing the number of viral infections, thus reducing the incidence of benign and malignant diseases caused by them and the mortality resulting from them. There are three vaccines on the pharmaceutical marketfor prevention of specific HPV infection. They are: a bivalent vaccine Cervarix, a tetravalent vaccine Gardasil and a nonavalent vaccine Gardasil 9. These vaccines are safe because they do not contain an attenuated virus particle, but their production is based on a virus-like particle of the main capsid protein L1-VLP. Gardasil 9 targets nine HPV types andcomparing to the other two vaccines it is the most effective at preventing the development of preinvasive cervical cancer. WHO recommends administering them to girls aged 9 to 14 in a two-dose schedule or from 15 years of age in a three-dose schedule. The side effects of the above-mentioned vaccines were mostly associated with a cutaneous reactions around the site of injection (pain, redness, swelling), and some people also experienced systemic symptoms such as a headache, a fever, vomiting, a dizziness, muscle pain and a diarrhea. The following article is an analysis of the current knowledge on the effectiveness and safety of prophylactic HPV vaccines based on publications available in the Pubmed and Google Scholar databases.

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“…There are approximately 200 different types of human papillomavirus (HPV),1 with types 16 and 18 being estimated to cause around 5% of all cancers worldwide 2. The virus is implicated in virtually all cases of cervical cancer, almost 90% of anal cancers and a significant proportion of oropharyngeal, penile, vaginal and vulval cancers 3.…”

Section: Introductionmentioning

confidence: 99%

Which interventions improve HPV vaccination uptake and intention in children, adolescents and young adults? An umbrella review

et al. 2022

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BackgroundHuman papillomavirus (HPV) vaccination offers protection against the virus responsible for cervical, oropharyngeal, anal, vulval and penile cancers. However, there is considerable variation across, and even within, countries as to how HPV vaccination is offered and accepted. This review aimed to identify what interventions exist to promote uptake and how effective they are.MethodsWe conducted an umbrella review using the JBI (Joanna Briggs Institute) methodology to evaluate routine or catch-up interventions to increase HPV vaccination uptake and/or intention for children aged 9 years and older, adolescents and young adults up to 26. Comprehensive searches for English language quantitative systematic reviews, published between January 2011 and July 2021, were conducted across five databases. After reviewing titles and abstract, relevant papers were independently assessed in detail.Main resultsFrom 1046 records identified, 10 articles were included in the review. They reported on 95 randomised controlled trials, 28 quasi-experimental studies, 14 cohort studies, 6 non-randomised pretest/post-test studies with control groups, 5 single-group pretest/post-test studies, 1 single-group post-test study and 1 randomised longitudinal study. Some interventions promoted change at the individual, community or organisational level, while others used a multicomponent approach. Face-to-face presentations, printed information and supplementing both strategies with additional components appear effective at increasing vaccination intention, while reminders and multicomponent strategies, especially ones that include some intervention aimed at provider level, appear effective at increasing vaccination uptake. Interventions that did not lead to an improvement in HPV vaccination intention or uptake varied in design and impacts were inconsistent across children/adolescents, young adults or parents.ConclusionThe evidence suggests that there is no single solution to increasing vaccination uptake and that different approaches may be better suited to certain populations. However, generalisations are limited by poor reporting and a paucity of studies beyond the USA. Further high-quality studies, therefore, are needed to understand how best to increase HPV vaccination uptake in different target populations.

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Potential Effects of Human Papillomavirus Type Substitution, Superinfection Exclusion and Latency on the Efficacy of the Current L1 Prophylactic Vaccines

Cited by 12 publications

References 79 publications

Effect of the Educational Package based on Health Belief Model on Nursing Students’ Knowledge and Attitude Regarding Human Papillomavirus and Cervical Cancer

Effect of the Educational Package based on Health Belief Model on Nursing Students’ Knowledge and Attitude Regarding Human Papillomavirus and Cervical Cancer

HPV virus as the main cause of cervical cancer, vaccination - literature review

Which interventions improve HPV vaccination uptake and intention in children, adolescents and young adults? An umbrella review

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