Potential Effects of Heavy Metals Bioaccumulation on Oxidative stress Enzymes of Mediterranean clam Ruditapes decussatus

Biochemical studies on the effect of prostaglandin inhibitors and willow bark extract on liver cirrhosis induced by acetylsalicylate in rats

“…By treatment with extract or ibuprofen or a combination of both in (G5, G6, and G7) respectively the concentration of GSH increased returning to the value of the normal range in G7. From the obtained results ibuprofen decreased the level of GSH in liver tissues of rats when it is used for a long duration also a high chronic dose of ASA plays a role in the decreased production of GSH these results are in agreement with previous studies (Beltagy et al, 2015;Gabr et al, 2020) which reported that ASA decreases GSH levels. Aspirin induces the formation of Nitric oxide (NO) radicals in the body.…”

“…ASA and IBP are capable of preventing lipid peroxidation and increasing the levels of glutathione, one of the most important oxidative defenses (Gabr et al, 2020;Beltagy et al, 2020) but this study showed that high chronic doses of ASA and IBP loss their ability to prevent lipid peroxidation while the level of lipid peroxidation indicators return to increase when ibuprofen used as a treatment for a short period after injection with ASA so of ibuprofen has two effects on a long duration of administration and short duration.…”

“…Treatment strategies for liver problems and detection methods depend on the amount and progression of liver fibrosis and the rate of cirrhosis development (Beltagy et al, 2020;Gabr et al, 2020). This study aims to assess the induced cirrhotic effect of high doses of prostaglandin inhibitors such as acetylsalicylate (ASA) administration on the liver of rats.…”

Integrated Use of Nanomechanical, Histological, and Biochemical Biomarkers of Oreochromis niloticus as a Signature of Metal Stress

“…Therefore, fish could be used as a "warning system" to indicate the presence of pollutants in natural aquatic (El-Hais et al, 2017). Biochemical alternations have been also proved sensitive biomarkers for the detection of interactions between pollutants and biological compounds (Gabr, et al, 2020;El-Hais et al, 2017). This study, therefore, investigated the utilization of an integrated biomarker approach of histological, nanomechanical, biochemical, and oxidative stress biomarkers in Oreochromis niloticus (Linnaeus, 1758) as a biological indicator of the health status of the freshwater ecosystem.…”