2019
DOI: 10.28932/jmh.v2i4.1057
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Potential Effects of Alkaloid vindolicine Substances in Tapak Dara Leafs (Catharanthus roseus (L.) G. Don) in Reducing Blood Glucose Levels

Abstract: Diabetes mellitus is a degenerative disease that commonly found and related to an unhealthy lifestyle and genetic factors. Current management of diabetes mellitus includes control of blood sugar levels and prevention of complications. Recent studies found that many phytochemicals have the potential to control blood sugar levels in patients with diabetes. Alkaloid substances from leaves of Tapak Dara have an effect on decreasing blood glucose. This review article aims to describe the potential effects of the Al… Show more

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Cited by 12 publications
(13 citation statements)
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“…Alkaloids are the most potent active chemical constituents of C. roseus. More than 400 alkaloids are present in the plant, which used as pharmaceuticals, agrochemicals, flavor and fragrance, ingredients, food additives, and pesticides (Satyarsa, 2019). The alkaloids like active plastidemeric, vinblastine, vincristine, vindesine, vindesine.…”
Section: Antimicrobial Properties Of Methanol Leaf Extract Of C Rosementioning
confidence: 99%
“…Alkaloids are the most potent active chemical constituents of C. roseus. More than 400 alkaloids are present in the plant, which used as pharmaceuticals, agrochemicals, flavor and fragrance, ingredients, food additives, and pesticides (Satyarsa, 2019). The alkaloids like active plastidemeric, vinblastine, vincristine, vindesine, vindesine.…”
Section: Antimicrobial Properties Of Methanol Leaf Extract Of C Rosementioning
confidence: 99%
“…34,49 Kolagen yang terdegradasi juga menghambat sintesis kolagen yang baru, disebabkan penurunan tensi mekanik dermal. 40,50 Pembentukan kolagen diregulasi oleh activator protein-1 (AP-1) dan transforming growth factor-β (TGF-β), yang keduanya memiliki fungsi yang berlawanan. TGF-β akan meningkatkan terjadinya sintesis kolagen sedangkan AP-1 akan meningkatkan produksi enzim pendegradasi kolagen, yaitu matrix metalloproteinases (MMPs).…”
Section: Spirulina Platensisunclassified
“…Pada pemaparan UVB, epidermal growth factor receptor (EGFR) akan teraktivasi dan menstimulasi P13 kinase/AKT. 48,50…”
Section: Spirulina Platensisunclassified
“…Salah satu potensi tanaman lokal yang dapat dipadukan dalam penciptaan produk pangan fungsional yaitu Tapak Dara (Chatarantus roseus L). Di Indonesia, tapak dara dikenal sebagai tanaman obat yang memiliki khasiat kesehatan (Satyarsa, 2019). Tanaman ini mudah tumbuh di halaman rumah, pemanfaatan daun tapak dara sebagai minuman kesehatan dilakukan dengan cara hanya merebus daunnya dengan air.…”
Section: Abstrakunclassified