Potential effects of advanced platelet rich fibrin as a wound-healing accelerator in the management of alveolar osteitis: A randomized clinical trial

Yüce, Esra; Kömerik, Nurgül

doi:10.4103/njcp.njcp_27_19

Cited by 37 publications

(53 citation statements)

References 3 publications

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“…This comes in agreement with many other studies that noted no appreciable difference on extraction sites when conventional PRF was applied as compared to regular extraction sites. [42][43][44][45][46][47][48][49] On the other hand, many studies reported that PRF usage decreased pain values significantly. 28,[50][51][52][53] In a randomized controlled clinical study that included 31 patients, Kumar et al 51 applied autologous platelet-rich fibrin after impacted mandibular third molar surgery and noted significant reduction of pain values on the first follow-up day.…”

Section: Discussionmentioning

confidence: 99%

Impact of Ozone gel, PRF & A-PRF on Pain and Trismus during Tissue Healing after Extraction of Mandibular Third Molars

Yousef

Ateia

Mansour

et al. 2021

Egyptian Dental Journal

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Objective: This prospective study evaluated the impact of ozone gel, conventional PRF (C-PRF) and advanced PRF (A-PRF) on pain and trismus when applied after surgical extraction of impacted mandibular third molars. Materials and Methods:This study included 48 patients with impacted mandibular third molars. They were randomly divided into 4 groups, group I (control); didn't receive any material in the socket, group II: sockets received ozone gel, group III: sockets received PRF while in group IV: sockets received A-PRF. Pain assessment using VAS, analgesics consumption, and maximum mouth opening were evaluated on day 1, day 3 and day 7 follow-up.Results: Less values of VAS pain scores were recorded in group II in comparison with the control group on day 1, day 3 and day 7 with a statistically significant difference of (P=0.018), (P=0.044) and (P=0.015) respectively. The analgesics consumption showed a statistically significant difference in group II compared to group I (P=0.020) and (P=0.021) on day 1 and day 3 respectively, but day 7 was statistically insignificant (P=0.165). Maximum mouth opening was statistically significant (P=0.042) on day3 in group II when compared with group I. Conclusion:The present study shows that ozone gel can be of paramount importance in minimizing post-operative symptoms as regard to pain and trismus following the extraction of impacted mandibular third molars and appears to improve patient's relief and quality of life after surgery.

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Section: Discussionmentioning

confidence: 99%

Impact of Ozone gel, PRF & A-PRF on Pain and Trismus during Tissue Healing after Extraction of Mandibular Third Molars

Yousef

Ateia

Mansour

et al. 2021

Egyptian Dental Journal

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“…An RCT by Yuce and Komerik 44 compared the use of saline irrigation versus PRF and found mean pain score was significantly lower in the PRF group. Soft tissue healing was also significantly faster.…”

Section: Resultsmentioning

confidence: 99%

Aetiology, Prevention and Management of Alveolar Osteitis—A Scoping Review

Ghosh

Aggarwal

Moore

2021

J of Oral Rehabilitation

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Background Alveolar osteitis (AO) is a poorly understood, common, painful complication following exodontia. It is sometimes managed by inappropriate prescription of antibiotics which contributes to the global threat of antimicrobial resistance. Use of intra‐alveolar chlorhexidine also presents a serious risk of anaphylaxis to the patient. Objective This scoping review aims to investigate the aetiology, prevention and management of AO and highlight the extent of inappropriate prescribing and intra‐alveolar chlorhexidine use. Design A scoping review was undertaken using the PRISMA guidelines. Medline, Ovid and Pubmed were searched between 2010 and 2020, from which 63 studies were selected for review that related to the aetiology, prevention or management of AO. Data were analysed for frequency of studies reporting information on risk factors for aetiology, prevention strategies and management including inappropriate management using antibiotic prescribing and intra‐alveolar chlorhexidine. Results Impaired immune response, surgical technique and age were identified as significant factors in the development of AO, while there is conflicting evidence regarding the effects of smoking and gender. With regard to prevention, the use of prophylactic antibiotics is not supported within the literature. Saline irrigation and eugenol pastes used preventively have been shown to be cheap and effective alternatives to chlorhexidine with no adverse effects. Hyaluronic acid and low‐level laser therapies showed a significant reduction in pain and soft‐tissue inflammation in the management of AO compared to Alveogyl. Conclusions Further understanding of the pathophysiology of AO is needed, in addition to large high‐quality RCTs or long‐term observational studies into the aetiology, prevention, and management of AO to produce up‐to‐date evidence‐based clinical guidelines. Clinicians should also be mindful of their contribution to growing antimicrobial resistance and avoid inappropriate prescribing of antibiotics. Saline should replace chlorhexidine as the intra‐alveolar irrigant of choice.

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“…Among the 12 RCTs included studies ( 8 , 13 , 15 - 19 , 22 - 25 , 27 ), 8 studies ( 15 , 17 , 18 , 22 - 25 , 27 ) were classified as unclear and 4 studies ( 8 , 13 , 16 , 19 ) were classified as high risk. The most frequent domain causing downgrading was allocation concealment.…”

Section: Resultsmentioning

confidence: 99%

Clinical management of alveolar osteitis. A systematic review

Garola¹,

Gilligan²,

Pánico³

et al. 2021

Med Oral

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Background Alveolar Osteitis (AO) is one of the most common complications of tooth extraction. Several therapeutic interventions have been described for the treatment of AO, however, there are no treatment standardized protocols. The aim of this study was to conduct a systematic review on the efficacy in pain control of the different treatments for AO. The feasibility of the application of these interventions is also discussed. Material and Methods A structured electronic and hand search strategy was applied to PubMed, Scopus, Cochrane Library, OpenGrey, and Google Scholar between January 2010 and July 2020 to identify studies according to PRISMA guidelines. The inclusion criteria were original English and Spanish clinical trials that analyzed pain-control parameters according to visual analog scale (VAS, 0-10 scale), or pain relief patients’ percentages. Those treatments that reach VAS ≤ 4 on day 2 or before; or ≥ 85% of patients with absence of pain symptoms at day 7 or before were considered accepTable for their recommendation. Results The final review included 17 clinical trials. Among them, there were analyzed a total of 39 different AO treatments. 53,8% of the treatments fulfill the proposed parameters for pain control. Conclusions Treatment alternatives are multiple, heterogeneous, and difficult to compare. The management of AO is summarized in basic (intra-alveolar irrigation) and specific procedures (Alveogyl®, Neocones®, SaliCept Patch®, Low-Level Laser, Platelet-Rich Fibrin) that reach pain control success. They could be selected according to their availability and advantages or disadvantages. Key words: Dry socket, alveolar osteitis, treatment, management, pain control, pain relief.

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Potential effects of advanced platelet rich fibrin as a wound-healing accelerator in the management of alveolar osteitis: A randomized clinical trial

Cited by 37 publications

References 3 publications

Impact of Ozone gel, PRF & A-PRF on Pain and Trismus during Tissue Healing after Extraction of Mandibular Third Molars

Impact of Ozone gel, PRF & A-PRF on Pain and Trismus during Tissue Healing after Extraction of Mandibular Third Molars

Aetiology, Prevention and Management of Alveolar Osteitis—A Scoping Review

Clinical management of alveolar osteitis. A systematic review

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